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Información requerida en el proceso de predicción

Capítulo 4 Aplicaciones de la técnica

4.1 Predicción de series de tiempo

4.1.1 Información requerida en el proceso de predicción

Dosage forms

Crude drug for infusion and hydroalcoholic extracts (35). Store in a well-closed container, protected from light and moisture (1).

Posology

(Unless otherwise indicated)

Daily dosage: 160–900 mg dried 45% ethanol or 70% methanol extract (drug:extract ratio 4–7:1) standardized to contain 18.75% oligomeric pro-cyanidins (calculated as epi-catechin) or 2.2% fl avonoids (calculated as hyperoside), respectively (26–29, 31–34, 84); 1.0–1.5 g comminuted crude drug as an infusion 3–4 times daily (35). Therapeutic effects may require 4–6 weeks of continuous therapy (84).

References

1. European pharmacopoeia, 3rd ed., Suppl. 2000. Strasbourg, Council of Eu-rope, 1999.

2. Pharmacopoeia of the People’s Republic of China. Vol. I (English ed.). Bei-jing, Chemical Industry Press, 1997.

3. Hänsel R et al., eds. Hagers Handbuch der pharmazeutischen Praxis. Bd. 4:

Drogen A-D, 5th ed. Berlin, Springer-Verlag, 1994.

4. Steinegger E, Hänsel R. Pharmakognosie. Berlin, Springer-Verlag, 1996:580–

584.

5. Farnsworth NR, ed. NAPRALERT database. Chicago, University of Illi-nois at Chicago, IL, February 9, 1998 production (an online database avail-able directly through the University of Illinois at Chicago or through the Scientifi c and Technical Network [STN] of Chemical Abstracts Services).

6. Newall CA, Anderson LA, Phillipson JD. Herbal medicines, a guide for healthcare professionals. London, Pharmaceutical Press, 1996.

7. Pharmacopoeia Hungarica, 7th ed. Budapest, Hungarian Pharmacopoeia Commission, Medicina Konyvkiado, 1986.

8. Ahumada C. The effects of a triterpene fraction isolated from Crataegus monogyna Jacq. on different acute infl ammation models in rats and mice.

Leucocyte migration and phospholipase A2 inhibition. Journal of Pharmacy and Pharmacology, 1997, 49:329–331.

9. Bruneton J. Pharmacognosy, phytochemistry, medicinal plants. Paris, Lavoisier, 1995.

10. Pizarro CM. Sinopsis de la Flora Chilena. Santiago, Ediciones de la Univer-sidad de Chile, 1966.

11. Tutin TG, ed. Flora Europea. Vol. 4. Cambridge, Cambridge University Press, 1976.

12. Deutsches Arzneibuch. Stuttgart, Deutscher Apotheker Verlag, 1998.

13. Pharmacopée française. Paris, Adrapharm, 1996.

14. Pharmacopoea helvetica, 8th ed. Berne, Département fédéral de l’intérieur, 1997.

15. British herbal pharmacopoeia. London, British Herbal Medicine Associa-tion, 1996.

16. Quality control methods for medicinal plant materials. Geneva, World Health Organization, 1998.

17. European pharmacopoeia, 3rd ed. Strasbourg, Council of Europe, 1996.

18. Guidelines for predicting dietary intake of pesticide residues, 2nd rev. ed. Ge-neva, World Health Organization, 1997 (document WHO/FSF/FOS/97.7).

19. Rehwald A, Meier B, Sticher O. Qualitative and quantitative reversed-phase high-performance liquid chromatography of fl avonoids in Crataegus leaves and fl owers. Journal of Chromatography A, 1994, 677:25–33.

20. Krawczyk U, Pteri G, Kery A. HPLC analysis of procyanidins in Crataegus extract. Archive der Pharmazie, 1991, 324:97–99.

21. Ficarra P et al. High-performance liquid chromatography and diffuse refl ec-tance spectroscopy of fl avonoids in Crataegus oxycantha L. III. Analysis of 2-phenylchroman derivatives and caffeic acid. Il Farmaco, 1990, 45:237–255.

22. Kolodziej H, Ferreira D, Roux DG. Synthesis of condensed tannins. Part 12. Direct access to [4,6]- and [4,8]-all-2,3-cis procyanidin derivatives from (–)-epicathechin: assessment of bonding positions in oligomeric analogues from Crataegus oxycantha L. Journal of the Chemical Society Perkin Trans-actions I, 1984:343–350.

23. Thompson RS et al. Plant proanthocyanidins. Part 1. Introduction: the iso-lation, structure, and distribution in nature of plant procyanidins. Journal of the Chemical Society Perkin Transactions I, 1972:1387–1399.

24. American Heart Association Medical/Scientifi c Statement. 1994 revisions to classifi cation of functional capacity and objective assessment of patients with heart diseases. Circulation, 1994, 90:644–645.

25. Bödigheimer K, Chase D. Wirksamkeit von Weissdorn-Extrakt in der Dosierung 3 × 100 mg täglich. Multizentrische Doppelblind-Studie mit 85 herzinsuffi zienten Patienten im Stadium NYHA II. Münchener Med-izinische Wochenschrift, 1994, 136 (Suppl. 1):18–21.

26. Eichstädt H et al. Crataegus-Extrakt hilft dem Patienten mit NYHA-II Herzinsuffi zienz. Untersuchung der myokardialen und hämodynamischen Wirkung eines standardisierten Crataegus-Präparates mit Hilfe computer-gestützter Radionuklidventrikulographie. Therapiewoche, 1989, 39:3288–

3296.

27. Förster A et al. Crataegus bei mässig reduzierter linksventrikulärer Auswurf-fraktion. Münchener Medizinische Wochenschrift, 1994, 136 (Suppl. 1):21–26.

28. Leuchtgens H. Crataegus-Spezialextrakt WS 1442 bei Herzinsuffi zienz NYHA II. Fortschritte der Medizin, 1993, 111:352–354.

29. Loew D. Crataegus-Spezialextrakte bei Herzinsuffi zienz. Gesicherte phar-makologische und klinische Ergebnisse. Der Kassenarzt, 1994, 15:43–52.

30. Loew D. Phytotherapy in heart failure. Phytomedicine, 1997, 4:267–271.

31. Schmidt U et al. Effect of hawthorne (Crataegus) preparation LI 132 in 78 patients with chronic congestive heart failure defi ned as NYHA functional class II. Phytomedicine, 1994, 1:17–24.

32. Tauchert M et al. Wirksamkeit des Weissdorn-Extraktes LI 132 im Ver-gleich mit Captopril. Münchener Medizinische Wochenschrift, 1994, 136 (Suppl. 1):27–33.

33. Weikl A, Noh HS. Der Einfl uss von Crataegus bei globaler Herzinsuffi -zienz. Herz und Gefässe, 1992:516–524.

34. Weikl A et al. Crataegus-Spezialextrakt WS 1442. Fortschritte der Medizin, 1996, 114:291–296.

35. Wichtl M. Crataegi folium cum fl ore. In: Wichtl, M ed. Teedrogen und Phy-topharmaka, 3rd ed. Stuttgart, Wissenschaftliche Verlagsgesellschaft, 1997:168–172.

36. Ammon HPT, Kaul R. Crataegus, Herz-Kreislauf-Wirkungen von Cratae-gusextrakten, Flavonoiden und Procyanidinen. Teil 1: Historisches und Wirkstoffe. Deutsche Apotheker Zeitung, 1994, 134:2433–2436.

37. Ammon HPT, Kaul R. Crataegus, Herz-Kreislauf-Wirkungen von Cratae-gusextrakten, Flavonoiden und Procyanidinen. Teil 2: Wirkungen auf das Herz. Deutsche Apotheker Zeitung, 1994, 134:2521–2535.

38. Ammon HPT, Kaul R. Crataegus, Herz-Kreislauf-Wirkungen von Cratae-gusextrakten, Flavonoiden und Procyanidinen. Teil 3: Wirkungen auf den Kreislauf. Deutsche Apotheker Zeitung, 1994, 134:2631–2636.

39. Brixius K et al. WS 1442 (Crataegus-Spezialextrakt) wirkt am insuffi zienten menschlichen Myokard Kontraktionskraft-steigernd. Herz Kreislauf, 1998, 30:28–33.

40. Joseph G, Zhao Y, Klaus W. Comparative studies on the effect of Crataegus extract and different positive inotropic substances on the effective refractory period of ventricular myocardium. Naunyn-Schmiedeberg’s Archives of Pharmacology, 1995, 351:R103.

41. Leukel A et al. Studies on the activity of Crataegus compounds upon the isolated guinea-pig heart. Planta Medica, 1986, 53:545–546.

42. Müller A et al. Crataegus extract prolongs action potential duration in guinea-pig papillary muscle. Phytomedicine, 1996, 3:257–261.

43. Occhiuto F et al. Étude comparée de l’activité cardiovasculaire des jeunes pousses, des feuilles et des fl eurs de Crataegus oxyacantha L. II. Action de préparations extractives et de principes actifs pur isolés sur le coeur isolés de lapin. Plantes médicinales et Phytothérapie, 1986, 20:52–63.

44. Pöpping S et al. Crataegus-Wirkung auf Kontraktion und O2-Verbrauch isolierter Herzzellen. Münchener Medizinische Wochenschrift, 1994, 136 (Suppl. 1):39–46.

45. Pöpping S et al. Effect of a hawthorn extract on contraction and energy turnover of isolated rat cardiomyocytes. Arzneimittel-Forschung, 1995, 45:1157–1161.

46. Schüssler M et al. Effects of fl avonoids from Crataegus species in Langen-dorff perfused isolated guinea pig hearts. Planta Medica, 1992, 58 (Suppl.

1):A646–A647.

47. Schüssler M et al. Myocardial effects of fl avonoids from Crataegus species.

Arzneimittel-Forschung, 1995, 45:842–845.

48. Wagner H, Grevel J. Herzwirksame Drogen IV; Kardiotone Amine aus Cra-taegus oxyacantha. Planta Medica, 1982, 45:98–101.

49. Costa R et al. Étude comparée de l’activité cardiovasculaire des jeunes pouss-es, des feuilles et des fl eurs de Crataegus oxyacantha L. III. Action protectrice sur le coeur isolés de rat vis-à-vis des agents arythmogènes et dans les aryth-mies par reperfusions. Plantes médicinales et Phytothérapie, 1986, 20:115–128.

50. Occhiuto F et al. Étude comparée de l’activité cardiovasculaire des jeunes pousses, des feuilles et des fl eurs de Crataegus oxyacantha L. I. Activité

elec-trique et tension arterielle chez le rat. Plantes médicinales et Phytothérapie, 1986, 20:37–51.

51. Thompson EB et al. Preliminary study of potential antiarrhythmic effects of Crataegus monogyna. Journal of Pharmaceutical Sciences, 1974, 63:1936–1937.

52. Manolov P, Nikolov KT. Crataemon experimental and clinical studies. Bul-letin Pharmachim, 1969, 1:1.

53. Petkov V, Manolov P. Pharmacological studies on substances of plant origin with coronary dilating and antiarrhythmic action. Comparative Medicine East and West, 1978, 6:123–130.

54. Gabard B, Trunzler G. Zur Pharmakologie von Crataegus. In: Reitbrock N et al., eds. Wandlungen in der Therapie der Herzinsuffi zienz. Braunschweig, Friedrich Vieweg und Sohn, 1983:43–53.

55. Nasa Y et al. Protective effect of Crataegus extract on the cardiac mechanical dysfunction in isolated perfused working rat heart. Arzneimittel-Forschung, 1993, 43:945–949.

56. Chatterjee SS et al. In vitro und in vivo-Untersuchungen zur kardioprotek-tiven Wirkung von oligomeren Procyanidinen in einem Crataegus-Extrakt aus Blättern mit Blüten. Arzneimittel-Forschung, 1997, 47:821–825.

57. Krzeminski T, Chatterjee SS. Ischemia and early reperfusion-induced ar-rhythmias: benefi cial effects of an extract of Crataegus oxyacantha L. Phar-macy and Pharmacological Letters, 1993, 3:45–48.

58. Makdessi SA et al. Myocardial protection by pretreatment with Crataegus oxyacantha. An assessment by means of the release of lactate dehydrogenase by the ischemic and reperfused Langendorff heart. Arzneimittel-Forschung, 1996, 46:25–27.

59. Mävers WH, Hensel H. Veränderungen der lokalen Myokarddurchblutung nach oraler Gabe eines Crataegus-Extraktes bei nichtnarkotisierten Hun-den. Arzneimittel-Forschung, 1974, 24:783–785.

60. Roddewig C, Hensel H. Reaktion der lokalen Myokarddurchblutung von wachen Hunden und narkotisierten Katzen auf orale und parenterale Ap-plikation einer Crataegus Fraktion (oligomere Procyanidine). Arzneimittel-Forschung, 1977, 27:1407–1410.

61. Hockerts T, Mülke G. Beitrag zur Frage einer Coronarwirkung von wässrigen Extrakten aus Crataegus-Droge. Arzneimittel-Forschung, 1955, 5:755–757.

62. Jacobi H et al. Studies on the coronary effect of Crataegus extracts. Arz-neimittel-Forschung, 1956, 6:98–99.

63. Kovach AGB et al. Effects of an extract from Crataegus oxyacantha on cor-onary blood fl ow in dogs. Arzneimittel-Forschung, 1958, 9:378–379.

64. Siegel G et al. Weissdorn-Extrakt LI 132. Münchener Medizinische Wochen-schrift, 1994, 136 (Suppl. 1):47–56.

65. Siegel G et al. Molecular physiological effector mechanisms of hawthorn extract in cardiac papillary muscle and coronary vascular smooth muscle.

Phytotherapy Research, 1996, 10 (Suppl. 1):S195–S198.

66. Abdul-Ghani AS et al. Hypotensive effect of Crataegus oxyacantha. Inter-national Journal of Crude Drug Research, 1987, 25:216–220.

67. Fehri B et al. Valeriana offi cinalis et Crataegus oxyacantha toxicité par ad-ministrations réitérées et investigations pharmacologiques. Journale de Pharmacie de Belgique, 1991, 46:165–176.

68. Liévre M et al. Étude des effets cardiovasculaires de l’hyperoside extrait de l’Aubépine chez le chien anesthésié. Annales pharmaceutiques françaises, 1985, 5:471–477.

69. Rácz-Kotilla E et al. Hypotensive and beta-blocking effect of procyanidins of Crataegus monogyna. Planta Medica, 1980, 39:239.

70. Bahorun T et al. Antioxidant activities of Crataegus monogyna extracts.

Planta Medica, 1994, 60:323–328.

71. Bahorun T et al. Oxygen species scavenging activity of phenolic extracts from hawthorn fresh plant organs and pharmaceutical preparations. Arz-neimittel-Forschung, 1996, 46:1086–1089.

72. Rakotoarison DA et al. Antioxidant activities of polyphenolic extracts from fl owers, in vitro callus and cell suspension culture of Crataegus monogyna.

Pharmazie, 1997, 52:60–64.

73. Petkov E et al. Inhibitory effect of some fl avonoids and fl avonoid mixtures on cyclic AMP phosphodiesterase activity of rat heart. Planta Medica, 1981, 43:183–186.

74. Schüssler M et al. Comparison of the fl avonoids occurring in Crataegus spe-cies and inhibition of 3’,5’-cyclic adenosine monophosphate phosphodies-terase. Planta Medica, 1991, 57 (Suppl. 2):A133.

75. Schüssler M et al. Cardiac effects of fl avonoids from Crataegus species.

Planta Medica, 1993, 59 (Suppl. 2):A688.

76. Vibes J et al. Inhibition of thromboxane A2 biosynthesis in vitro by the main components of Crataegus oxyacantha (hawthorn) fl ower heads. Prostaglan-dins, Leukotrienes and Essential Fatty Acids, 1994, 50:173–175.

77. Vibes J et al. Effects of a methanolic extract from Crataegus oxyacantha blossoms on TXA2 and PGI2 synthesising activities of cardiac tissue. Medi-cal Science Research, 1993, 21:435–436.

78. Wrocinski T. Determination of the activity of spasmolytic drugs with refer-ence to the papaverine standard. Biuletyn Instytutu Roslin Lecznniczych, 1960, 6:236.

79. Beretz A et al. Choix de méthodes pharmacologiques pour l’étude des acti-vités de l’aubépine. Plantes médicinales et Phytothérapie, 1978, 12:305–314.

80. Della Loggia R et al. Depressive effect of Crataegus oxyacantha L. on cen-tral nervous system in mice. Science and Pharmacy, 1983, 51:319–324.

81. Borkowski B. Diuretic action of several fl avone drugs. Planta Medica, 1960, 8:95–104.

82. Schlegelmilch R, Heywood R. Toxicity of Crataegus (hawthorne) extract (WS 1442). Journal of the American College of Toxicology, 1994, 13:103–111.

83. Hecker-Niediek AE. Untersuchungen zur Biogenese, Markierung und Pharmakokinetik der Procyanidine aus Crataegus-Species [Dissertation].

Marburg, University of Marburg, 1983.

84. Blumenthal M et al., eds. The complete German Commission E monographs.

Austin, TX, American Botanical Council, 1998.

85. Schimmer O et al. The mutagenic potencies of plant extracts containing quercetin in Salmonella typhimurium TA98 and TA100. Mutation Research, 1988, 206:201–208.

86. Albrecht A, Juretzek W. Weissdorn (Crataegus laevigata, Crataegus mono-gyna), Weissdornblätter mit Blüten (Crataegi folium cum fl ore). Berlin, Springer: Loseblatt System Naturheilverfahren, 1995.

Defi nition

Herba Equiseti consists of the whole or cut, dried sterile aerial parts of Equisetum arvense L. (Equisetaceae) (1, 2). The same parts collected dur-ing the summer are described in the USSR pharmacopoeia as Herba Equi-seti arvensis (2).

Synonyms

E. calderi Boivin (3).

Selected vernacular names

Acker-schachtelhalm, acherschachtelhalm, ager-padderokke, åkersnelle, åkerfräken, akkerpaardestaart, at kuyrugi, baimbap, at quyroughi, bottle-brush, brusca, cauda de cavalo, chieh hsu ts’ao, coada calului, coda caval-lina, coda equine, cola de caballo, common horsetail, corn horsetail, dhanab al khail, dhanab el khayl, dhanab et faras, dutch rushes, equiseto menor, equiseto dei boschi, equiseto dei campi, equisette, equisetto, erva carnuda, false horse-tail, fi eld horsetail, foxtail, gongbangcho, heermoes, horse-pipe, horse pipes, horsetail, horsetail grass, horsetail rush, horse willow, hvoshtsh, jeinsol, jointed rush, kannenkraut, kattestaart, kilkah asb, klóelfting, koniogon, kosa tīruma, krypfräken, librus, macho, mare’s tail, meadow pine, moeraspaardestaart, mokjeok, moonhyung, paddock-pipes, peltokorte, pest’shi, petite prêle, pewterwort, pildoochae, pildooy-eup, pine grass, pinetop, polevaja sosenka, prele, prêle des champs, põl-dosi, queue de cheval, queue de rat, queue de renard, rabo de cavalo, rasperella, rävrumpa, scouring rush, shvita, snake grass, soettgi, soksae, sugina, toadpipe, tolkatshnik, tomahwang, tsukushi, vara de oro, wen ch-ing, western horsetail, zinngras, zinnkraut (3–16).

Geographical distribution

Distributed throughout the temperate zone of the northern hemisphere.

Indigenous to all of America, Europe and North Africa, as well as parts of Asia. Found widely throughout the Newly Independent States region,

with the exception of deserts, paramos and the northern regions (4, 5, 7, 8, 17–21).

Description

A perennial plant with sterile and fertile stems. Rhizomes: horizontal, up to 3 mm in diameter, layered, extending to a depth of about 1 m, brown-ish-black, branched, creeping, with blackish tubers up to 7 mm in diam-eter. Roots: at the bases of lateral branch buds, on both rhizomes and erect shoots. Fertile stems: ephemeral, appear early in the spring, 15–

20 cm high, up to 5 mm in diameter, unbranched, succulent, reddish or yellowish, jointed, with 6–12 blackish-brown lanceolate teeth at the joints. Cones: apical, ovate-cylindrical, blunt-tipped, 1–3.5 cm long. The strobile is situated under peltate polygons, which are pileus-like bodies, arranged in whorls; 4–7 spiral fi laments surround the green globular spores, which roll up closely around them when moist, and uncoil when dry. The fertile stem never turns green. The green, sterile shoots develop later from the rhizome, by which time the fertile shoots have usually wilted. Sterile stems: 5–15(80) cm high, erect, 6–18(20) grooved, hollow, jointed, up to 20 whorls of slender branches. Leaves scale-like, decidu-ous, inconspicudecidu-ous, in whorls at the nodes, are connected at their bases (4, 5, 18, 19, 22–27).

Plant material of interest: dried sterile aerial parts

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