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her2 hyper-activation through the production of carboxy-terminal fragments

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Academic year: 2017

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Figure

Figure 1: Schematic representation of the four members belonging to the EGFR (or ErbB) family of human receptors
Figure 3.extracellular region of a prototypical ErbB receptor, from the N-terminus the order of the four domains is  ErbB receptors extracellular region: Main structural features characterizing the L1-CR1-L2-CR2
Figure 4. Dimerization process upon binding of a soluble ligand. In the case of HER1, HER3 or HER4, binding of the ligand (yellow) promotes the interaction between the domains I and III of the receptor and induces an outward rotation (142º)
Figure 5. Proposed dimerization process for HER2: A. Dimerization and activation of DER are tightly
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