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PGE2 induces MUC2 and MUC5AC expression in human intrahepatic biliary epithelial cells via EP4/p38MAPK activation

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Academic year: 2020

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Figure

Figure 1. Induction of COX-2 expression and PGE2 production in HIBECs by LPS in a TLR4-NFkB-dependent manner (A) LPS
Figure 3. Induction of MUC2 and MUC5AC expression in HIBECs by exogenous PGE 2  (A) and (B) exogenous PGE 2  (1, 10 and 100 µmol/L) stimulated MUC2 mRNA and MUC5AC mRNA expression in a dosage-dependent manner, P < 0.01, respectively
Figure 4. PGE 2 -induced MUC2 and MUC5AC upregulation mediated by EP4 receptor (A) and (B) selective EP4 agonist ONO-AE1- AE1-329 (5 µmol/L) stimulated MUC2 and MUC5AC mRNA expression in HIBECs
Figure 5. MUC2 and MUC5AC upregulation by PGE 2 /EP4 in HIBECs requiring P38MAPK activation (A) expression of phosphorylated

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