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Bombesin induces a reduction of somatostatin inhibition of adenylyl cyclase activity, Gi function, and somatostatin receptors in rat exocrine pancreas

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Academic year: 2020

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Fig. 1. Dose– effect curves for 5 ⬘guanylylimidodiphosphate [Gpp(NH)p] on forskolin (FK)-stimulated adenylyl cyclase (AC) activity in rat  pancre-atic acinar membranes from control (F) and rats treated with bombesin for 7 days (E) or 14 days (‚)
Fig. 3. Left: Competitive inhibition of [ 125 I-Tyr 11 ]somatostatin ([ 125 I-Tyr 11 ]SS) (35 pM) binding to pancreatic acinar membranes by unlabeled somatostatin (SS)

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