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Determination of diphenhydramine hydrochloride in rabbit plasma by LC-MS/MS and its application to a pharmacokinetic study

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1372 ISSN 0326-2383

KEY WORDS:Diphenhydramine hydrochloride, Liquid chromatography-tandem mass spectrometry, Pharma-cokinetics, Plasma.

*Author to whom correspondence should be addressed. E-mail:[email protected]. #These authors contributed equally to these work.

Latin American Journal of Pharmacy

(formerly

Acta Farmacéutica Bonaerense)

Lat. Am. J. Pharm. 30

(7): 1372-6 (2011)

Regular Article Received: February 2, 2011 Revised version: May 15, 2011 Accepted: May 19, 2011

Determination of Diphenhydramine Hydrochloride in Rabbit Plasma

by LC-MS/MS and its Application to a Pharmacokinetic Study

Jianshe MA

1

#, Meiling ZHANG

2

#, Yangping SHENTU

1

, Yuqing ZHANG

1

,

Xiaofang FAN

1,3

&Yongsheng GONG

1,3

*

1

Function Experiment Teaching Center, Wenzhou Medical College, Wenzhou 325035, China.

2

Analytical and Testing Center of Wenzhou Medical College, Wenzhou 325035, China;

3

Institute of Hypoxia Medicine, Wenzhou Medical College, Wenzhou 325035, China.

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