Aplicación de la "Toxina botulínica A" en el tratamiento del Síndrome Aurículo-Temporal

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(7) Indice ............................................................ 7 Introducción ..................................................... 9 Síndrome de Frey o Aurículo-temporal ......................................... 11 Fisiopatología ............................................................................ 13 Clínica ........................................................................................ 18 Diagnóstico................................................................................ 30 Opciones de tratamiento............................................................ 31 La toxina botulínica.............................................................................. 33 Introducción.............................................................................. 33 Historia..................................................................................... 37 Descripción de la molécula...................................................... 39 Mecanismo de acción............................................................... 41 Principios inmunológicos......................................................... 47 Farmacocinética....................................................................... 48 Manipulación........................................................................... 50 Contraindicaciones.................................................................. 51 Interacciones............................................................................ 52 Efectos adversos...................................................................... 53 Potencia................................................................................... 54 Duración.................................................................................. 55 Seguridad................................................................................. 57 Estabilidad............................................................................... 60 Otras aplicaciones................................................................... 61. Justificación del estudio................................. 63 Epidemiología del síndrome.............................................................. 67. Revisión de la literatura................................. 69 Hipótesis de trabajo....................................... 73 Objetivos del estudio..................................... 77 Material y métodos........................................ 81 Primera visita..................................................................................... 90 Realización del test de Minor............................................................ 91 Listado de pacientes del estudio........................................................ 93 Preparación de la toxina..................................................................... 95 Dosificación....................................................................................... 97 Técnica de inyección......................................................................... 99 Seguimiento....................................................................................... 101. Resultados..................................................... 103 Discusión...................................................... 109 Conclusiones................................................. 127 Bibliografía................................................... 131.

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