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Diclofenac quantification: analytical attributes of a spectrophotometric method

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1001 ISSN 0326-2383

KEY WORDS:Diclofenac, Quantification, Spectrophotometry, Tablets.

* Author to whom correspondence should be addressed. E-mail:mcsarno@exa.unne.edu.ar

Latin American Journal of Pharmacy

(formerly

Acta Farmacéutica Bonaerense)

Lat. Am. J. Pharm.

30

(5): 1001-4 (2011)

Short communication Received: September 29, 2010 Revised version: November 3, 2010 Accepted: November 4, 2010

Diclofenac Quantification:

Analytical Attributes of a Spectrophotometric Method

Celina M. MONZÓN, Mario R. DELFINO (h), María del C. SARNO* and Mario R. DELFINO

Instrumental Analysis Laboratory- School of Exact and Natural Sciences,

Northeastern National University (UNNE) Av. Libertad 5640, Corrientes, Argentina

SUMMARY. An spectrophotometric UV-visible technique used to quantify diclofenac and its application to pharmaceutical preparations is described, based on diclofenac oxidation by Fe(III) in the presence of o-phenanthroline. The formation of tris(o-phenanthroline)-Fe(II) complex (ferroin) upon diclofenac reaction was investigated. Absorbance of ferroin complex was measured at 506 nm. This method was tested on 50 mg tablets. Operating with placebos, it was found that excipients do not interfere with the determination. A good linearity was found [y = (0.0294 ± 0.0041)x + (0.1326 ± 0.0559)] with r2= 0.9982, calibration curve

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