Contributors . . . .xiii Foreword. . . xxvii
Foreword to the First Edition .xxix
Preface . . . xxxi
SECTION 1
Foundation Issues
Section Editor: L. Michael Posey
1. Pharmacoeconomics: Principies,
Methods, and Applications 6) . . . .. 1 Lisa Sanehez Trask
2.
Health Outcomes and Health-RelatedQuality of Life
e
3Stephen Joe/ Coons
3.
Health Literacy and Medication UseCD . . . .. 5 Oralia V. Bazaldua and Sunil Kripalani4. Cultural Competency CD . . . 7
Jeri J. Sias, Amanda M. Loya, José O. Rivera,
Arthur A. Islas, and Ulysses]. Urquidi
5. Principies and Practices
of Medication Safety CD . . . 9
Seott M. Mark, Jeffrey D. Little, Sarah E. Adkins, and Robert J. Weber
6. Evidence- Based Medicine CD 11
Elaine Chiquette and L. Miehae/ Posey
7.
Documentation of Pharmacy Services (i\ . . . .. 13George E. MaeKinnon III and Neil J. MaeKinnon
8. Clinical Pharmacokinetics and
Pharmacodynamics e. . . .. 15
Larry A. Bauer
9. Pharmacogenetics (\\ . . . .. 17
Larisa H. Cavallari and Y. W. Francis Lam
10.
Pediatrics4'
19Milap C. Nahata and Carol Taketomo
11.
GeriatricsCD oo 21Emily R. Hajjar, Shelly L. Gray, David R.P. Guay, Catherine 1. Starner, Steven M. Handler, and Joseph T. Hanlon
12.
Palliative Care.
23Jill Astolfi
13. Pharmacoepidemiology CD . . . 25
Andy Stergaehis,Thomas K. Hazlet, and Denise Boudreau
14. Clinical Toxicology . . . 27
Peter A. Chyka
1 5. Emergency Preparedness: Identification and
Management of Biologic Exposures
&. . . .
51Colleen M. Terriff, Jason E. Brouillard, Lisa T. Costanigro, and Jessiea S. Oftebro
16. Emergency Preparedness: Identification and
Management of Chemical and Radiologic
Exposures
~ . . . .
.. . . .
.. .
.. . . .53 Greene Shepherd and Riehard B. SehwartzSECTION 2
Cardiovascular Disorders
SectionEditor:Robert
L.Talbert
17. Cardiovascular Testing. . . 55
Riehard A. Lange and L. David Hillis
1 8. Cardiac Arrest . . . 83
Jeffrey F. Barletta and Jeffrey L. Wilt
19. Hypertension . . . 101
Joseph J. Saseen and Erie ]. Maclaughlin
20. Systolic Heart Failure . . . .. 137
Robert B. Parker and Larisa H. Cavallari
21.
Diastolic Heart Failure and theCardiomyopathies .. . . .. 173
Jean M. Nappi and Robert L. Page II
22.
Acute DecompensatedHeart Failureo oooooooo ooooooooooooooooooooo oo 191
lo EoRodgers and Craig R. Lee
23. Ischemic Heart Diseaseo . . . . oo oo oo oo oo o. . . 209
Robert L. Talbert
24. Acute Coronary Syndromes. o o o 241
Sarah Ao Spinler and Simon De Denus
25. The Arrhythmias ooooo oooooo o. . . .. . oooooooo oo 273
Cynthia Ao Sanoski and lerry L. Bauman
26.
Venous Thromboembolismo o o o o o.. o o o o o o o o o o 0311 Daniel M. Witt, Edith AoNuteseu,and Stuart T. Haines
27. Stroke o o o o o . . o o o o o o o o o o o . . . . o . o o o o o o o o o o o o . . 353
Susan C. Fagan and David C. Hess
28. Dyslipidemiao o o o o o o o.. o. o o o o o o o o o o o o o. o. o o o o365
Robert L. Talbert
29.
Peripheral Arterial Disease. . . o o o o o o o o o o . . . o . 389Barbara J. Hoeben and Robert L. Talbert
30. Use ofVasopressors and
Inotropes in the Pharmacotherapy
of Shock. o o o o o o o o o o o . o o o o o o o o o o o o . . . . o o o o o o o399
Robert Maclaren, Maria lo Rudis, and loseph F. Dasta
31. Hypovolemic Shock. o o o o o o o o o o o... o o o o o o o o o o o 421
Brian L. Erstad
SECTION 3
RespiratoryOisorders
Section Editor: Robert L. Talbert
32. Introduction to Pulmonary
FunctionTesting6) o o o o o o o o o o o o o o o . . . . o o o o o o437
lay l. Peters and Stephanie M. Levine
33. Asthma o o o o . . o o o o . . . o . . . o o o o o 439 H. William Kel/y and Christine Ao Sorkness
34. Chronic Obstructive
Pulmonary Disease . . o o o o o o o o o o o o o o o o o o o o . o o . 471
Dennis M. Williams and Sharya Vo Bourdet
35. Pulmonary Arterial Hypertension . o. . . 497
Rebecca Moote, Rebecca L. Attridge, and Deborah 'o Levine
36. Drug- Induced Pulmonary Disease . . . 511
Hengameh Ho Raissy, Miehel/e Harkins, and Patrieia L. Marshik
37.
Cystic Fibrosis .. .. .. . ooo.. .. . .. .. .. . .. . . o525ChaninC. Wrightand YolandaY. Vera
SECTION4
Gastrointestinal
Oisorders
SectionEditor:JosephT. DiPiro
38. Evaluation of the Gastrointestinal
Tract. . . oo . . . oo oo . . . oo oo o. . 539
Keith M. Olsen and Grant FoHutehins
39.
Gastroesophageal Reflux Diseaseo o o o o o o . . . o . o o549Dianne B. Williams and Robert R. Sehade
40.
Peptic Ulcer Disease . . . o o o . . o o o o o o . . o o o o o o . 563Rosemary R. Berardi and Randolph VoFugit
41. Inflammatory Bowel Disease . . . oo. o. o. 587
Brian Ao Hemstreet
42.
Nausea and Vomitingo o . . . o . o o o . . . . o o o o o o . . . .607 Cecily V. DiPiro and Robert J. 19noffo43. Diarrhea, Constipation, and Irritable
Bowel Syndrome o o o. 621
Patricia Ho Powel/ and Virginia Ho Fleming
44.
Portal Hypertension and Cirrhosiso o o o o . o o o o o o o 639lulie Mo Sease
45.
Drug-Induced Liver Disease o. o oo oo . . . oo . . o. . . 659William R. Kirehain and Rondal/ E. Al/en
46. Pancreatitis. o o o o . . . o . o o o o o o . . . o o o o . . . o o o o o . . 669
Seott Bolesta and PatriciaAoMontgomery
47.
Vira! Hepatitis .. .. .. . oo.. .. .. . ooo.. .. ooo.. . . 685 Paulina Deming48. Drug Therapy Individualization in Patients with Hepatic Disease and Genetic Alterations in Drug
Metabolizing Activity o. . . ooooo. o. . . o. . . 705 YoWoFrancis Lam
49.
Celiac Disease&.. o o o o o o o o.. o o o 0717Robert Ao Mangione and Priti N. Patel
SECTION 5
Renal Oisorders
SectionEditor:GaryRoMatzke
50. Clinical Assessment of Kidney Function . . . oo 719 Thomas C. Dowling
51. Acute Kidney Injury . . . o. . . o. . .741 WilliamDager and lenana Hali/ovie
52. Chronic Kidney Disease:
Progression-Modifying Therapieso. o . . . o o o o o o o o767
Vimal K. Derebail, Abhijit Vo Kshirsagar,
and Melanie Soloy
53. Chronic Kidney Disease:
Management of Complications . . . 787 Joanna Q. Hudson
54. Hemodialysis and Peritoneal Dialysis 6) . . . 817
Kevin M. Sowinski and Mariann D. Churchwell
55. Drug-Induced Kidney Disease. . . 819
Thomas D. Nolin and Jonathan Himmelfarb
56. Glomerulonephritis 837
Alan H. Lau
57.
Drug Therapy Individualization forPatients with Chronic Kidney Disease. . . 861
Gary R. Matzke
58.
Disorders ofSodium and WaterHomeostasis . . . 873
James D. Coyle and Gary R. Matzke
59. Disorders of Calcium and Phosphorus
Homeostasis. . . 891
Amy Barton Pai
60.
Disorders of Potassium and MagnesiumHomeostasis. . . 909
Donald F. Brophy and Jane Frumin
61. Acid-Base Disorders . . . 923
John W. Devlin and Gary R. Matzke
-,
, '.,
.
~..
Neurologlc Disorders
Section Editor: Barbara G. Wel/s
62. Evaluation ofNeurologic Illness 943
Susan C.Fagan and Fenwick T. Nichols
63. Alzheimer's Disease. . . 947
Patricia W. Slattum, Russell H. Swerdlow,
and Angela Massey Hill
64. Multiple Sclerosis. . . .. . . 963
Jacquelyn L. Bainbridge and John R. Corboy
65. Epilepsy . . . 979
Susan ]. Rogers and Jose E. Cavazos
66. Status Epilepticus. . . 1007 Stephanie]. Phelps,Collin A. Hovinga,
and James
w.
Wheless67.
Acute Management oftheBrain Injury Patient. . . 1019
Bradley A. Boucher and Shelly D. Timmons
68. Parkinson's Disease. . . 1033
Jack]. Chen, Merlin V.Nelson,
and David M. Swope
69. Pain Management . . . 1045
Terry J. Baumann, Jennifer M. Strickland, and Chris M. Herndon
70. Headache Disorders . . . 1061
Deborah S. Minor
SECTION 7
psychiatric Disorders
Section Editor: Barbara G. Wel/s
71.
Evaluation of Psychiatric Illness . . . .. 1077MarkE. Schneiderhan, Leigh Anne Nelson,
and Stuart Munro
72. Childhood Disorders. . . .1087
Julie A. Dopheide and StephenR. Pliszka
73.
Eating Disorders 1101Steven C. Stoner
74. Substance-Related Disorders:
Overview and Depressants, Stimulants,
and Hallucinogens. . . 1113
Paul L. Doering
75. Substance-Related Disorders: Alcohol,
Nicotine, and Caffeine .. . . .. 1131
PaulL. Doeringand RobinMoorman U
76.
Schizophrenia . 1147M. Lynn Crismon, Tami R. Argo, and Peter F. Buckley
77.
Major Depressive Disorder 1173Christian]. Teter, Judith C. Kando, and Barbara G. Wells
78. Bipolar Disorder . . . 1191
Shannon J.Drayton
79. Anxiety Disorders 1: Generalized Anxiety, Panic,
and Social Anxiety Disorders. . . 1)09
Sarah T. Melton and Cynthia K. Kirkwood
80.
Anxiety Disorders 11: Posttraumatic Stress Disorder and Obsessive-CompulsiveDisorder. . . .. 1229
CynthiaK. Kirkwood, Usa B. Phipps, and Barbara G. Wells
81. Sleep Disorders. . . .. . . .. 1241 JohnM. Dopp and Bradley G. Phillips
82. Disorders Associated with
Intellectual Disabilities
8
. . . 1253 Nancy Brahm,Jerry Mckee, and Douglas StewartSECTION
8
Endocrinologic Disorders
Section Editor: Robert L. Talbert
83. Diabetes Mellitus. . . 1255
Curtis 1. Triplitt and CharlesA. Reasner
84. Thyroid Disorders. . . 1303 JacquelineJonklaas and Robert 1. Talbert
85. Adrenal Gland Disorders 1327
Steven M. Smith and John G. Gums
86.
Pituitary Gland Disorders . . . 1345 Amy Heck Sheehan, Jack A. Yanovski,and Karim Anton Calis
SECTION
9
Gynecologic and Obstetric
Dlsorders
SectionEditor: Barbara C. We/ls
87. Pregnancy and Lactation:
Therapeutic Considerations. . . 1361 Kristina E. Ward and Barbara M. O'Brien
88. Contraception . . . 1377 Sarah P. Shrader, Kelly R. Ragucci,
and VanessaA. Diaz
89. Menstruation-Related Disorders. . . .. 1393
Elena M. Umland, Lara Carson Weinstein, and Edward M. Buchanan
90. Endometriosis . . . 1409
Deborah A. Sturpe
91.
Hormone Therapy in Women 1417Sophia N. Kalantaridou, Devra K. Dang,
Susan R. Davis, and Karim Anton Calis
SECTION 10
UrologicDisorders
Section Editor: L. Michael Posey
92. Erectile Dysfunction . . . 1437
Mary Lee
93. Benign Prostatic Hyperplasia. . . 1455 Mary Lee
94. Urinary Incontinence . . . 1467 Eric S. Rovner, Jean Wyman,
Thomas Lackner, and David R.P. Guay
SECTION 11
Immunologic Disorders
SectionEditor:Cary
e Yee
95. Function and Evaluation of the
Immune System . . 1487
PhilipD. Hall,NicoleWeimertPilch, and DanielH. Atchley
96. Systemic Lupus Erythematosus and
Other Collagen-Vascular Disorders 1505
JeffreyC. Delafuenteand KimberlyA. Cappuzzo
97. Allergic and Pseudoallergic
Drug Reactions. . . 1521
Lynne M. Sylvia and Joseph T. DiPiro
98. Solid-Organ Transplantation. . . .. 1537
Heather j. Johnson and Kristine S. Schonder
~'l 3 jr'11tnlngic Disorderc;
SectionEditor:L. Michael Posey
~~ Osteoporosis and Other Metabolic
Bone Diseases. . . 1559
Mary Beth O'Connell and Sheryl F. Vondracek
00 Rheumatoid Arthritis ... . . . 1583
Arthur A. Schuna
101 Osteoarthritis 1599
Lucinda M. Buys and Mary Elizabeth Elliott
01. Gout and Hyperuricemia. . . .. 1621 Michael E. Ernst and ElizabethC. Clark
SECTION 13
Ophthalmicand OtolaryngologicalDisorders
Section Editor: L. Michael Posey
103.
Glaucoma . . . 1633Richard G. Fiscella, Timothy S. Lesar, and Deepak P. Edward
104. Allergic Rhinitis. . . 1649
j. RussellMay and Philip H. Smith
SECTION 14
Dermatologic Disorders
SectionEditor:L. Michael Posey
105.
Dermatologic Drug Reactionsand Common Skin Conditions.. 1661
Rebecca M. Law and David T.S. Law
1 06. Acne V ulgaris. . . . .. . . .. . . 1673
Debra J. Sibbald
107.
Psoriasis 1693Rebecca M. Law and Wayne P. Gul/iver
108. Atopic Dermatitis . . . 1707
Rebecca M. Law and Po Gin Kwa
SECTION 15
Hematologic Disorders
Section Editor: Gory C. Yee
109. Anemias 1717
KristenCook,BeataA. lneck,and William1. Lyons
11O.
Coagulation Disorders . . . 1741Betsy Bickert Poon, Char Witmer, and Jane Pruemer
111. Sickle Cell Disease . . . .. 1765
C. Y. Jennifer Chan and Reginald Moore 112. Drug-Induced Hematologic
Disorders. . . 1781
Christine N. Hansen and Amy F. Rosenberg
SECTION 16
Infectious Diseases
SectionEditor:Joseph T.DiPiro
113.Laboratory Tests to Direct Atimicrobial
Pharmacotherapy. . . 1797
Michael J.Rybak, Jeffrey R. Aeschlimann,
and Kerry 1. Laplante
114. Antimicrobial Regimen Selection. . . .1813
David S.Burgess
115. Central Nervous System Infections. . . 1825
Isaac F. Mitropoulos, Elizabeth D. Hermsen, and John C. Rotschafer
116.LowerRespiratory Tract Infections . . . .. 1845
Martha G. Blackford, Mark 1. Glover, and Michael D. Reed
117.
Upper Respiratory Tract Infections . . . .. 1867Christopher Frei, Bradi Frei, and George Zhanel
118. Influenza. . . .1881
Jessica C. N)oku and Elizabeth D. Hermsen
119. Skin and Soft- Tissue Infections. . . .. 1893
Douglas N. Fish, Susan 1. Pendland, and Larry H. Danziger
120. Infective Endocarditis. . . 1913
Angie Veverka and Michael A. Crouch
121. Tuberculosis. .. . . .. . . 1931
CharlesA. Peloquin and Rocsanna Namdar
122. Gastrointestinal Infections and
Enterotoxigenic Poisonings . . . 1951
Steven Martin and RoseJung
123.
Intraabdominal Infections . . . 1969Joseph T. DiPiro and Thomas R. Howdieshell
124. Parasitic Diseases. . . 1981
J. V. Anandan
125. Urinary Tract Infections and Prostatitis . . . 1995 Elizabeth A. Coyle and Randall A. Prince
126. Sexually Transmitted Diseases. . . 2011 Leroy C. Knodel
127.
Bone and Joint Infections . 2029Edward P. Armstrong and Allan D. Friedman
128.
Severe Sepsis and Septic Shock. . . 2041S. Lena Kang-Birken and Karla Killgore-Smith
129.
Superficial Fungal Infections . . . 2055Thomas E. R. Brown, Linda D. Dresser, and Thomas W. F. Chin
130. Invasive Fungal Infections . . . 2073
Peggy 1. Carver
131. Infections in Immunocompromised
Patients . . . 2105
Douglas N. Fish
132.
Antimicrobial Prophylaxis in Surgery . . . 2131 Salmaan Kan)i133. Vaccines, Toxoids, and Other
Immunobiologics. . . 2147
Mary S.Hayney
134. Human Immunodeficiency Virus Infection . . . . 2169
Peter 1. Anderson, Thomas N. Kakuda,
and Courtney V.Fletcher
SECTION
17Oncologic Disorders
Sedion Editor: Gory C. Yee
135. Cancer Treatment and Chemotherapy .2191
Patrick J. Medina and Stacy S. Shord
136. Breast Cancer . . . 2229
Laura Boehnke Michaud, Chad M. Barnett, and Francisco J. Esteva
137. Lung Cancer. . . 2271
DeborahA. Friezeand ValR.Adams
138. Colorectal Cancer . . . 2287
Lisa E. Davis, Weijing Sun, and Patrick J. Medina
139. Prostate Cancer . . . 2319
LeAnn B. Norris and Jill M. Ko/esar
140. Lymphomas . . . 2333
A/exandreChanand GaryC. Yee
141. Ovarian Cancer . . . 2361
JudithA. Smith andJudithK. Wolf
142.
Acute Leukemias . . . 2377Betsy Bickert Poon and Dianne M. Brundage
143. Chronic Leukemias . . . 2401
Christopher A. Fause/ and Patrick ]. Kie/
144. Multiple Myeloma . . . 2417
Timothy R. McGuire and Casey B. Williams
145. Myelodysplastic Syndromes .. . . .2431 Julianna A. Burzynski and Tracey Wa/sh-Choco/aad
146. Renal Cell Carcinoma" . . . 2433
Christine M. Wa/ko, Ninh M. La-Beck. and Mark D. Wa/sh
147. Melanoma. . . 2435
Cindy 1. O'Bryant and Jamie c. Poust
148. Hematopoietic Stem Cell
Transplantation . . . 2455
Janelle B. Perkins and Gary C. Yee
Nutntional
Oisorders
Section Editor:Gary R. Matzke
149. Assessment ofNutrition Status,
and Nutrition Requirements . . . 2473 Katherine Hammond Chessman
and Vanessa]. Kumpf
150. Medication Administration Considerations
with Specialized Nutrition Support . . . 2493
Ro/and N. Dickerson and Gordon S. Sacks
151.
Parenteral Nutrition . . . 2505Todd W.Mattoxand CatherineM. Crill
J52. Enteral Nutrition . . . 2527
Vanessa ]. Kumpf and Katherine Hammond Chessman
153.
Nutritional Considerations in MajorOrgan Failure . . . 2545
Brian M. Hodges and Mark DeLegge
154. Obesity. . . 2567 Judy T. Chen, Amy Heck Sheehan,
JackA. Yanovski, and Karim Anton Calis
Glossary. . . 2585
