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Obtaining microcapsules with albumin with programmed properties

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1755 ISSN 0326-2383

KEY WORDS:Microcapsules, Albumin, Efficiency, Degree of incorporation, Release time.

* Author to whom correspondence should be addressed. E-mail: b.dolinska@biochefa.pl

Latin American Journal of Pharmacy

(formerly

Acta Farmacéutica Bonaerense)

Lat. Am. J. Pharm.

30

(9): 1755-60 (2011)

Regular Article Received: April 15, 2011 Revised version: June 3, 2011 Accepted: June 5, 2011

Obtaining Microcapsules with Albumin with Programmed Properties

Barbara DOLINSKA

1

*, Anna GALCZYNSKA-PAWLIK

2

,

Aneta OSTRÓZKA–CIESLIK

1

, Janusz PLUTA

2

, Beata ROSAK

1

& Florian RYSZKA

3

1

Department of Applied Pharmacy, Medical University of Silesia, 41-205 Sosnowiec, Kasztanowa 3, Poland

2

Chair and Department of Pharmaceutical Technology,

Wroclaw Medical University, 50-139 Wroclaw, ul. Szewska 38, Poland

3

“Biochefa” Pharmaceutical Research and Production Plant, 41-205 Sosnowiec, Kasztanowa 3, Poland

SUMMARY. The aim of this study was: a) the determination of the relation between composition of mix-ture for microencapsulation (gelatin concentration 5, 10, and 15 %; sodium alginate 2, 4, and 6 %; acetic acid 15, 20, and 30 %) and the efficiency of the obtained microcapsules, b) the degree of human serum al-bumin (HSA) incorporation, and c) the release time of HSA from microcapsules. Existing relations was de-scribed by multiple regression equations on the basis of which it can be obtained HSA gelatin-alginate micocapsules with specified release time and with specified efficiency and degree of protein incorporation. The aim was realized by modeling the composition of mixture for microencapsulation. HSA microcapsules were prepared using complex coacervation method. Based on presented multiple regression equations it was possible to obtain HSA microcapsules with specified efficiency, degree of incorporation and release time.

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