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Roles of calcium and Mitochondria Associated Membranes in the development of obesity and diabetes

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Academic year: 2020

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Figure 1 The arcuate nucleus neurons (ARC) Neuropeptide Y/Agouti related-proteins (NPY/AgRP) and propiomelacortics (POMC) coordinate the activity of the paraventricular (PVN) nucleus, promoting the stimulation or inhibition of apetite, respectively
Figure 2 Misfolded Protein Response (MPR). When the flow of misfolded proteins to the ER is increased, the BIP protein chaperone is released from IRE-1␣, PERK and ATF6, allowing it to act as a transcription factor and allowing chaperone proteins synthesis,
Figure 3 The Mitochondria-Associated Membranes (MAMs) are a microdomain made up of different proteins which are in charge of calcium homeostasis, transport of lipids, mitochondrial morphology and the oversight of cellular death
Figure 4 The development of obesity promotes an increase in between ER and mitochondrias contacts in the liver, leading to mitochondria Ca 2+ overload and oxidative damage and inflammation generation.

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