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Evaluation of ethanol extracts of leaves and fruit of Piper sarmentosum for in vivo hepatoprotective activity

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1215 ISSN 0326-2383

KEY WORDS:CCl4-induced oxidative stress, Hepatoprotective activity, Liver function markers, Piper sarmen-tosum, Piperaceae.

* Author to whom correspondence should be addressed. E-mail:hussain_761@yahoo.com

Latin American Journal of Pharmacy

(formerly

Acta Farmacéutica Bonaerense)

Lat. Am. J. Pharm.

29

(7): 1215-20 (2010)

Original article Received: January 24, 2010 Revised version: March 19, 2010 Accepted: March 23, 2010

Evaluation of Ethanol Extracts of Leaves and Fruit

of

Piper sarmentosum

for

In Vivo

Hepatoprotective Activity

Khalid HUSSAIN*, Zhari ISMAIL & Amirin SADIKUN

School of Pharmaceutical Sciences, Universiti Sains Malaysia,

Pulau Pinang-11800, Malaysia

SUMMARY. The present study is aimed to describe hepatoprotective activity of extracts of a medicinal plant, Piper sarmentosum,in rats against CCl4-induced toxicity. Seven groups ofSprague Dawleyrats each

containing six animals were treated as: group I (CCl4), group II (control), group III and IV (fruit extract

500 and 250 mg/kg, respectively), group V and VI (leaf extract 500 and 250 mg/kg, respectively) and group VII (vitamin-E). The extracts and vitamin-E were administered orally for 14 days whilst equivalent amount of sample vehicle was administered to CCl4and control groups. Four hour following the last dose,

a single dose of CCl4(1.5 mg/kg, 1:1 olive oil) was administered orally to animals of all the groups except

control. After 24 h blood was collected for the determination of hepatic function markers, and the animals were sacrificed to get liver for histology. Comparison of hepatic function markers and histology of pre-treated and CCl4groups indicated that both the extracts in the two doses had protected liver from CCl4

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