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Use of short term genotoxicological tests to study cytotoxic, genotoxic and cell death mechanism of metronidazole

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1319 ISSN 0326-2383

KEY WORDS: Cell death, Cytotoxicity, Genetic toxicology, Genotoxicity, Metronidazole, Short term tests.

* Author to whom correspondence should be addressed. E-mail:mmlopeznigro@gmail.com

Latin American Journal of Pharmacy

(formerly

Acta Farmacéutica Bonaerense)

Lat. Am. J. Pharm.

29

(8): 1319-27 (2010)

Original Article Received: Janurary 29, 2010 Revised version: March 23, 2010 Accepted: March 28, 2010

Use of Short Term Genotoxicological Tests to Study Cytotoxic,

Genotoxic and Cell Death Mechanism of Metronidazole

Marcela M. LÓPEZ NIGRO

1

*, Marta D. MUDRY

2

& Marta A. CARBALLO

1

1

CIGETOX (Citogenética Humana y Genética Toxicológica) - INFIBIOC (Instituto de Fisiolopatología y

Bioquímica Clínica) - Facultad de Farmacia y Bioquímica. Universidad de Buenos Aires. Junín 956

(C1113AAD), Ciudad Autónoma de Buenos Aires, Argentina.

2

GIBE-Grupo de Investigación en Biología Evolutiva. Dpto. Ecología, Genética y Evolución. Facultad de

Ciencias Exactas y Naturales. Universidad de Buenos Aires. Pab. II,

(C1428EHA), Ciudad Autónoma de Buenos Aires, Argentina.

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