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Synthesis and DNA interaction of ethylenediamine platinum(II) complexes linked to DNA intercalants

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Academic year: 2020

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Figure  1.  Viscometric  measurement  experiments  of  calf  thymus  DNA  and  compounds  1-6  at  25  ºC  (10  mM  sodium phosphate buffer, pH  = 7.2)
Figure 2. The bar graphs indicate the concentrations of bound ligands 2 (light blue), 3 (orange), 5 (dark blue) and  6 (brown) detected after a 24 h equilibration in competition binding dialysis studies of four DNA sequences
Table S1. Nucleic Acid Samples Used in Competition  Dialysis Experiments a    Deoxyribonucleic acid  (nm)  (M -1  (bp)cm -1 )  CT DNA (42% GC)  260  12,824  CP DNA (31% GC)  260  12,476  [poly(dGdC)] 2  (100% GC)  254  16,800  [poly(dAdT)] 2  (0% GC)  262

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