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Metformin reactivity with biuret: application to tablets

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1244 ISSN 0326-2383 KEY WORDS: biuret, metformin, UV-visible spectrophotometry.

*Author to whom correspondence should be addressed. E-mail: mcsarno@exa.unne.edu.ar

Latin American Journal of Pharmacy

(formerly

Acta Farmacéutica Bonaerense)

Lat. Am. J. Pharm.

30

(6): 1244-8 (2011)

Short communication Received: March 3, 2011 Revised version: March 22, 2011 Accepted: March 24, 2011

Metformin Reactivity with Biuret: Application to Tablets

Cecilia L. CHAHIN, Mario R. DELFINO, & María del C. SARNO*

School of Exact and Natural Sciences - Northeastern National University (UNNE),

Instrumental Analysis Laboratory - Av. Libertad 5460- Corrientes- Argentina

SUMMARY. A spectrophotometric method was developed for the analysis of metformin, based on its re-action with the biuret reagent. A complex with λmax= 495 nm and stoichiometry 2:1 (metformin-Cu) is

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