1244 ISSN 0326-2383 KEY WORDS: biuret, metformin, UV-visible spectrophotometry.
*Author to whom correspondence should be addressed. E-mail: mcsarno@exa.unne.edu.ar
Latin American Journal of Pharmacy
(formerly
Acta Farmacéutica Bonaerense)
Lat. Am. J. Pharm.
30
(6): 1244-8 (2011)
Short communication Received: March 3, 2011 Revised version: March 22, 2011 Accepted: March 24, 2011
Metformin Reactivity with Biuret: Application to Tablets
Cecilia L. CHAHIN, Mario R. DELFINO, & María del C. SARNO*
School of Exact and Natural Sciences - Northeastern National University (UNNE),
Instrumental Analysis Laboratory - Av. Libertad 5460- Corrientes- Argentina
SUMMARY. A spectrophotometric method was developed for the analysis of metformin, based on its re-action with the biuret reagent. A complex with λmax= 495 nm and stoichiometry 2:1 (metformin-Cu) is