• No se han encontrado resultados

Antibacterial activity of two pregnenolone-derivatives against Vibrio cholerae and Escherichia coli and its relationship with descriptors LogP, Π

N/A
N/A
Protected

Academic year: 2017

Share "Antibacterial activity of two pregnenolone-derivatives against Vibrio cholerae and Escherichia coli and its relationship with descriptors LogP, Π"

Copied!
1
0
0

Texto completo

(1)

759 ISSN 0326-2383

KEY WORDS: E. coli,Pregnenolone-carbamazepine, Pregnenolone-vitamin B1, V. cholerae.

* Author to whom correspondence should be addressed. E-mail:lauro_1999@yahoo.com

Latin American Journal of Pharmacy

(formerly

Acta Farmacéutica Bonaerense)

Lat. Am. J. Pharm.

30

(4): 759-64 (2011)

Original Article Received: February 17, 2010 Revised version: Octobre 8, 2010 Accepted: October 11, 2010

Antibacterial Activity of Two Pregnenolone-Derivatives

against

Vibrio cholerae

and

Escherichia coli

and its Relationship with Descriptors

LogP

,

Π

Lauro FIGUEROA

1

*, Francisco DÍAZ

2

, Maria LÓPEZ

1

,

Abelardo CAMACHO

3

, Elodia GARCIA

1

& Rolando OZAETA

1

1

Universidad Autónoma de Campeche, Agustín Melgar s/n entre Juan de la Barrera y C-20,

Col Bellavista C.P. 24039 Campeche Cam., México.

2

Escuela de Ciencias Biológicas del IPN. Plan de San Luís y Díaz Mirón s/n

Col. Santo Tomas, México, D.F. C.P. 11340.

3

Facultad de Medicina de la Universidad Juárez del Estado de Durango,

es Av. Fanny Anitua s/n Esq. Av. Universidad. C.P. 34000, Durango, Dgo., México.

SUMMARY. In this work the antibacterial activity of two pregnenolone-derivatives was evaluated on V. cholerae and E. coli,using a NCCLS broth dilution modified method. Additionally, to delineate the struc-tural chemical requirements of the steroid derivatives as antibacterial agents on E. coli and V. cholerae, other parameters such as the physicochemical descriptors LogP and π were calculated. The results ob-tained indicate that bacterial growth of E. coli and V. choleraewas inhibited with pregnenolone-vitamin B1 (MIC = 6.64. x 10–4mmol/mL) and pregnenolone-carbamazepine (MIC = 3.18 x 10–4mmol/mL). Other

Referencias

Documento similar

In this paper we propose the use of a central hardware device that can be used with existing CAN-Bus systems for the communication of the system devices and its external

The current approach to the measurement of QOL can be characterized by its multidimensional nature involving core domains and indicators, the use of methodological pluralism

On the other hand, the larvae from 18 ovipostions that were kept in the laboratory at ambient temperatu- re emerged between two and four days after they were collected in the

The aim of the present article has been to analyze the literature on the epidemiology of injuries in two aspects of aerobic gymnastics: as a physical leisure activity and a

Results: No differences were found between the two groups regarding quality of life, but results indicate that in supported employment high levels of typicalness are associated with

With the objective of increasing the capacity and impact of research activity, the USC has been working for years in reorganizing its R&D capacity with the belief that

A causal relationship with the PSDs and extraction of determinants, unlike in the literature, cannot be established, because of the nature of the focus group and the

In this case, the other feedback signal, i LFeedback , changes its number of fractional bits (Q8.Y) and i R is set to Q2.10, so only these two signals can be the cause of the