Analytical considerations for the successful evaluation of hyoscyamine biotransformation into 6β-hydroxyhyoscyamine and scopolamine

582 ISSN 0326-2383 KEY WORDS: 6β-hydroxyhyoscyamine, Biotransformation, Hyoscyamine, Hyoscyamine-6β-hydroxylase,

Scopolamine.

* Author to whom correspondence should be addressed. E-Mail:acardillo@ffyb.uba.ar

Latin American Journal of Pharmacy

(formerly

Acta Farmacéutica Bonaerense)

Lat. Am. J. Pharm.

31

(4): 582-7 (2012)

Regular Article Received: December 6, 2011 Revised version: May 24, 2012 Accepted: May 25, 2012

Analytical Considerations for the Successful Evaluation

of Hyoscyamine Biotransformation into 6β-Hydroxyhyoscyamine

and Scopolamine

Alejandra B. CARDILLO*, Julián RODRÍGUEZ TALOU & Ana M. GIULIETTI

Cátedra de Microbiología Industrial y Biotecnología, Facultad de Farmacia y Bioquímica,

Universidad de Buenos Aires Junín 956, 6° piso, Buenos Aires, (CP 1113). Argentina.