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Integrin avB3 acting as membrane receptor for thyroid hormones mediates angiogenesis in malignant T cells

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Academic year: 2020

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Figure 1. THs mediate proliferative effects in TCL cell lines. (A) mRNA levels of ITGAV, ITGB3, and THRA in a panel of TCL cell lines in comparison with mRNA levels in normal T cells
Figure 2. Integrin avb3 is the membrane receptor for THs in human TCL. (A) Blockade of the TH-mediated proliferative effect by 1 nM RGD peptide, added 10 minutes before 24-hour hormone treatment, was analyzed by Cell Titer Blue assay
Figure 3. THs acting at the membrane receptor initiate a transcriptional program. (A) A graphical heatmap representation of changes (log 2 fold change) in gene expression of CUTLL1 cells after treatment with TH-AG vs CT (AG alone); n 5 3 independent sample
Figure 4. THs contribute to TCL malignant phenotype through angiogenesis induction. (A) Pearson correlation between ITGAV and ITGB3 with VEGFB and VEGFA levels in TCL patients
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