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Bases genéticas de la Enfermedad Pulmonar Obstructiva Crónica

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(1)!. !!!!!!!! !. ! "#$%&'%(#)'*!+#!,-*.*/0%!1!2-#)3-%4!+#!.%!5%.6+! !. TESIS DOCTORAL 2015 ! ! !. ! ! ! ! !. BASES GENÉTICAS DE LA ENFERMEDAD PULMONAR OBSTRUCTIVA CRÓNICA Volumen III!. !!!!!!!!!!!!!!!!!!David Blanquer Escribano (doctorando) !!!!!!!!!!!!!!!!!!! !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!7-3#)3-%+*!#)!8#+-3-)%9!! !!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!8:+-3*!;4$#3-%.-4'%!#)!<#6(*.*/0%! ! !!!!!!!!!!!!!!!!!!!!!!!=&*/&%(%!+#!"*3'*&%+*>!8;"?2?<@!A!2?;<2?@5!,B5?2@5!. !!. !.

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(29) !. ]j]9!k*&1'-)%!gRN!@mO(%+-4O-)%!7GN!?%)S%#M%!"gN!r-m'*&*M%!Jr9!=*.1(*&$O-4(!-)!$&*(*'#&!&#/-*)4! *C!(%'&-c!(#'%..*$&*'#-)%4#4!U88=\N!88=aN!%)+!88=\]V!-)!3O&*)-3!*S4'&63'-M#!$6.(*)%&1! +-4#%4#!$%'-#)'49!g#)#'-m%9!]^^jhbbU]V>]b]f]ba9! ! ]je9!D%Y!?N!2O%$$#..!5N!H*O)4*)!5EN!#'!%.9!@44*3-%'-*)!*C!88=T]!$*.1(*&$O-4(4!l-'O!4#M#&#!%)+!M#&1! 4#M#&#!2I=">!%!3%4#!3*)'&*.!4'6+1!*C!88=4T\N!a!%)+!\]!-)!%!;6&*$#%)!$*$6.%'-*)9!,82!8#+!g#)#'9! ]^\^h\\>d9! ! ]jb9!7##!5AN!k-(!8HN!k%)/!DgN!#'!%.9!=*.1(*&$O-4(4!-)!(%'&-c!(#'%..*$&*'#-)%4#T\N!Ta!%)+!T\]!/#)#4! %)+!'O#!&-4m!*C!3O&*)-3!*S4'&63'-M#!$6.(*)%&1!+-4#%4#!-)!%!k*&#%)!$*$6.%'-*)9!E#4$-&%'-*)9!]^\^h! j^U]V>\eef\ej9! ! ]j_9!M%)!"-#(#)!22N!=*4'(%!"5N!5-#+.-)4m-!8N!,.*m4'&%!@N!5(-'!D@N!,*#P#)!D89!g#)#'-3!M%&-%'-*)!-)! J?8=\!S6'!)*'!88=4!$&#+-3'!#c3#44!R;r\!+#3.-)#!-)!'l*!/#)#&%.!$*$6.%'-*)TS%4#+!3*O*&'49!E#4$-&! E#49!]^\\h\]>_d9! ! ]ji9!5%)'64!=N!2%4%)*M%!RN!,-*)+-!87N!,.%4-!RN!"-!8%&3*!RN!2#)'%))-!59!5'&*(#.14-)T\!$*.1(*&$O-4(! %4!%!)#l!$*'#)'-%.!&-4m!C%3'*&!-)!$&*/&#44-*)!*C!3O&*)-3!*S4'&63'-M#!$6.(*)%&1!+-4#%4#9!8*)%.+-! @&3O!2O#4'!"-49!]^^ahd\U\V>\_f]^9! ! ]jd9!53O-&(#&!DN!,%44*!+%!5-.M%!7N!J#-c#-&%!=HN!8*&#-&%!H5N!8*&#-&%!@7N!5-(*)!"9!8%'&-c! (#'%..*$&*'#-)%4#!/#)#!$*.1(*&$O-4(4>!.%3m!*C!%44*3-%'-*)!l-'O!3O&*)-3!*S4'&63'-M#!$6.(*)%&1! +-4#%4#!-)!%!,&%P-.-%)!$*$6.%'-*)9!g#)#'!8*.!E#49!]^^ahjUeV>\^]jf\^eb9! ]jj9!?'*!?N!<%/%-!5N!D%)+%!JN!#'!%.9!8%'&-c!(#'%..*$&*'#-)%4#Ta!$&*(*'#&!$*.1(*&$O-4(!%44*3-%'#+! l-'O!6$$#&!.6)/!+*(-)%)'!#($O14#(%9!@(!H!E#4$-&!2&-'!2%&#!8#+9!]^^_h\d]U\\V>\edjf\ej]9! ! ]ja9!8-)#(%'46!<N!<%m%(6&%!DN!J%'#)*!DN!<%m%W-(%!JN!A%(%/63O-!k9!g#)#'-3!$*.1(*&$O-4(!-)! (%'&-c!(#'%..*$&*'#-)%4#Ta!%)+!$6.(*T!)%&1!#($O14#(%9!,-*3O#(!,-*$O14!E#4!2*((6)9! ]^^\h]jaU\V>!\\if\\a9! ! ]a^9!GO*6!8N!D6%)/!5gN!n%)!DAN!7-!,N!"#)/!nnN!7-!89!g#)#'-3!$*.1(*&$O-4(!-)!(%'&-c! (#'%..*$&*'#-)%4#Ta!%)+!'O#!4643#$'-S-.-'1!'*!3O&*)-3!*S4'&63'-M#!$6.(*)%&1!+-4#%4#!-)!D%)! $*$6.%'-*)!*C!4*6'O!2O-)%9!2O-)!8#+!H!U;)/.V9!]^^bh\\dU\^V>\bj\f\bjb9! ! ]a\9D6))-)/O%m#!g8N!2O*!8DN!J#4C%-/P-!AN!#'!%.9!88=\]N!.6)/!C6)3'-*)N!%)+!2I="!-)!O-/OT&-4m! $*$6.%'-*)49!<!;)/.!H!8#+9!]^^ahei\U]dV>!]_aaf]i^j9! ! ]a]9!D%Y!?N!7*l&#1!g;N!k%.4O#m#&!<N!H*O)4*)!5E9!8%'&-c!(#'%..*$&*T!'#-)%4#T\]!U88=T\]V!5<=! %CC#3'4!88=!%3'-M-'1N!.6)/!(%3&*$O%/#!-)C-.'&%'-*)!%)+!$&*'#3'4!%/%-)4'!#($O14#(%!-)!2I="9! JO*&%c9!]^\\h!iiU\\V>ad^fadi9! ! ]ae95%-'*O!nN!5%m%(*'*!JN!D#/%S!@;N!#'!%.9!88=\b!/#)#!$*.1(*&$O-4(4!-)!3O&*)-3!*S4'&63'-M#! $6.(*)%&1!+-4#%4#9!?)'!H!8*.!8#+9!]^^ih\dUbV>!i]\fi]i9! ! ]ab9!IO%&!H@N!D%(-.'*)!ER!H&N!GO#)/!5N!#'!%.9!2I="!-4!%44*3-%'#+!l-'O!%!(%3&*$O%/#!43%M#)/#&! &#3#$'*&T\!/#)#!4#Y6#)3#!M%&-%'-*)9!2O#4'9!]^\^h\edU_V>\^ajf\\^d9! ! ]a_9!D6%!22N!2O%)/!72N!J4#)/!H2N!2O6!28N!7-6!A2N!5O-#O!n,9!R6)3'-*)%.!O%$.*'1$#4!-)!'O#!$&*(*'#&! &#/-*)!*C!'&%)43&-$'-*)!C%3'*&!<&C]!-)!3O&*)-3!*S4'&63'-M#!$6.(*)%&1!+-4#%4#9!"-4!8%&m#&49!]^\^h! ]jUeV>\j_f\ae9! ! ]ai9!@&-C!;N!@O4%)!@N!r-SO6'-!@N!#'!%.9!;)+*'O#.-%.!)-'&-3!*c-+#!41)'O%4#!/#)#!M%&-%)'4!3*)'&-S6'#!'*! *c-+%'-M#!4'&#44!-)!2I="9!,-*3O#(!,-*$O14!E#4!2*((6)9!]^^dhei\U\V>\j]f\jj9! !. "B!. !.

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FUNCIONES Y RESPONSABILIDADES

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