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Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1

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Academic year: 2020

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Figure

Fig. 1. Dopaminergic neurons of XBP1-deficient mice are resistant to 6-OHDA –induced neurotoxicity
Fig. 2. ER stress in XBP1-deficient SNpc. (A) (Left) Levels of the ER stress- stress-responsive proteins calreticulin and ERp72 were determined by Western blot analysis in midbrain tissue dissected from XBP1 WT and XBP1 Nes−/− mice.
Fig. 3. XBP1 down-regulation in dopaminergic neurons of adult SNpc induces spontaneous  neuro-degeneration and chronic ER stress
Fig. 4. Local delivery of XBP1s into the SNpc protects dopaminergic neurons against 6-OHDA –induced neurotoxicity

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