Date: 8 March Curriculum vitae Thomas Brioche

Curriculum vitae Thomas Brioche

Date: 8 March 2013

PERSONAL DATA

Family name: Brioche Forename: Thomas

Date of birth : 12 March 1987 Gender: M Nacionality: French

PRESENT PROFESIONAL POSITION Phd Student of Physiology

Institution: University of Valencia Faculty, School or Institute: Medicine Department: Physiology

Address: Avda. Blasco Ibanez, 15. 46010 Valencia.

Country: Spain

Telephone (indicate prefix, number and extension): +34-963864154 Fax: +34-963864642

E-mail: [email protected]

Field of study (UNESCO codes): 2411.06 (Physiology)

Professional status: Phd Student Start date: April 2010 Administrative status

Permanent Staff Hired on contracts Acting Fellowship holder

Others specify:

Full-time Part-time

PRESENT RESEARCH AREA Brief summary (key words).

Physiology of Exercise Anti-oxidant

Anti-Aging Sarcopenia Longevity

ACADEMIC BACKGROUND

Bachelor Centre Date

International Master’s degree (Hons) in “Physical Activity and Sport Sciences in Europe” specialty « Movement Sport Healt”

University of Rennes 2 in collaboration with University of Valencia 2010

BSc Science and Technology of Sport and Physical Activity (STAPS)- Specialty

University of Rennes 2 2008

Physical Activity for the Disabled -

BSc (Hons) in Science and Technology of Sport and Physical Activity (STAPS) – Specialty Physical Training

University of Rennes 2 2008

PAST SCIENTIFIC EXPERIENCE (*)

Position R&D Centre Institution (**) Start date End date Fellowship Laboratory

Movement, Sport, Health

University of

Rennes 2008 2010

(*) The information contained in this chart will be used to verify the placement requirements, according to the section 42.1.c) of the Call. (**) If the Institution is a “joint centre”, you should specify all the centres involved in running it.

LANGUAGES (N = NORMAL, G = GOOD, P = PERFECTLY)

Language Speaking Reading Writing

Inglish Good Good Good

Spanish Perfectly Perfectly Perfectly

PARTICIPATION IN RESEARCH PROJECTS

PUBLICATIONS

BOOKS

Fabian Sanchis-Gomar, Vladimir Martinez-Bello, Helios Pareja-Galeano, Brioche T, Mari Carmen Gómez-Cabrera. Chapter title: An overview of doping in sports. In Nutrition and Enhanced Sports Performance: Recommendations for Muscle Building.

Being published by ELSEVIER

ARTICLES

Brioche T*, Cuesta S*, Gomez-Cabrera MC, Gratas-Delamarche A, Tresguerres JA, and Viña J. Growth hormone replacement therapy prevents sarcopenia by a dual mechanism: stimulation of protein synthesis and of antioxidant defenses. (Manuscript Submitted to the Journals of Gerontology Series A Biological Sciences)

Helios Pareja-Galeano; Thomas Brioche; Fabián Sanchis-Gomar; Consuelo Escrivá;

Mar Dromant; Mari Carmen Gómez-Cabrera; José Viña. Effects of physical exercise on cognitive alterations and oxidative stress in an APP/PSN1 transgenic model of Alzheimer's disease. Rev Esp Geriatr Gerontol. 2012 Sep;47(5):198-204

Helios Pareja-Galeano*, Thomas Brioche*, Fabian Sanchis-Gomar, Angeles Montal, Carmen Jovaní3, Cecilia Martínez-Costa4, Mari Carmen Gomez-Cabrera, and Jose Viña. Impact of exercise training on neuroplasticity-related growth factors in adolescents. Accepted in Journal of Musculoskeletal and Neuronal Interactions, 2013 Mari Carmen Gomez-Cabrera, Beatriz Ferrando, Thomas Brioche, Fabian Sanchis- Gomar, and Jose Viña. Exercise and antioxidant supplements in the elderly. Accepted in Journal of Sport and Health Science

Fabian Sanchis-Gomar, Helios Pareja Galeano, Thomas Brioche, Giuseppe Lippi.

Addressing altitude exposure in the Athlete’s Biological Passport. Submitted to Journal of Strength and Conditioning Research,2013

Fabian Sanchis-Gomar , Vladimir E. Martinez-Bello, Frédéric Derbré, Ernesto Garcia- Lopez, Rebeca Garcia-Valles, Thomas Brioche, Beatriz Ferrando, Sandra Ibanez- Sania, Helios Paleja-Galeano, Mari Carmen Gomez-Cabrera, José Viña. Rapid hemodilution induced by desmopressin after erythropoietin administration in humans.

JOURNAL OF HUMAN SPORT & EXERCISE, 2011; 6 (2)

Sanchis-Gomar, F ; Martinez-Bello, V. E. ; Martinez-Bello, D. A. ; Nascimento, A. L. ;

García-Vallés, R. ; Brioche, T. ; Ferrando, B. ; Ibáñez-Sania, S. ; Pareja-Galeano, H. ;

Gómez-Cabrera, M.C. ; Viña, J. Modificaciones hematologicas inducidas por eritropoyentina frente a hypoxia normobarica intermitente. Motricidad. European Journal of Human Movement, 2010: 25, 93-104

STAYS IN INTERNATIONALLY RECOGNIZED CENTRES

Centre: Laboratory Movement, Sport, Health: Research area: Obesity and Adolescence and exercise: Effect of endurance training on plasma volume changes induced by the carrying out of incremental exhaustive exercise Supervisor : Pr Sophie Lemoine-Morrel, 2009

Centre: University of Valencia, Alzheimer's Disease and Physical Activity: Impact of training on aerobic physical skills, memory and behavior. Study in a transgenic mouse model (Supervisor : Pr Mari-Carmen Gomez), 2010, 4 meses

PRESENTATIONS IN CONGRESSES

O r a l c o m m u n i c a t i o n s

• T Brioche. Mecanismo de prevención de la sarcopenia con hormona de crecimiento.

Máster en Fisiología Envejecimiento saludable y ejercicio físico. 21-25 Mayo de 2012.

Valencia, Spain

• Jovani Casano, C.; Brioche, T.; Pareja-Galeano, H.; Gómez-Cabrera, MC.; Montal, MA.; Viña, J.; Martínez Costa, C. RELACIÓN ENTRE EJERCICIO FÍSICO Y EL INCREMENTO DE FACTORES NEUROTRÓFICOS (BDNF E IGF- I)RELACIONADOS CONLA FUNCIÓN COGNITIVA EN ADOLESCENTES. XIX Congreso de la Sociedad Española de Gastroenterología, Hepatología y Nutrición Pediátrica. Las Palmas de Gran Canaria, España. 17-19 Mayo 2012.

• Pareja-Galeano, Helios, Brioche Thomas. EFFECTS OF EXERCISE TRAINING ON COGNITIVE DEFICITS AND BIOLOGICAL ALTERATIONS IN AN APP/PSN1 TRANSGENIC MICE MODEL FOR ALZHEIMER´S DISEASE. The 20

International Congress on Sport Science for Students. Semmelweis University. Budapest, Hungría.

26-28 Abril 2012.

• Pareja-GaleanoH. , Brioche T. , Jovani C. , Montal MA, Sanchis-Gomar F. , Gomez- Cabrera MC, Martinez-Costa C. and Viña J. El Entrenamiento físico esta asociado con un incremento periférico de factores neurotroficos en adolescentes. Posibles implicaciones en la function cognitiviva. IV Jornadas Nacionales de medicina del deporte de la federación española de medicina del deporte, November 2011, Reus, Spain

POSTERS

• T Brioche, S Cuesta, H Pareja-Galeano, H Cabo, MC Gomez-Cabrera, A Gratas Delamarche, JA Tresguerres, and J Viña. Beneficial Effects of Growth Hormone in the Treatment of Skeletal Muscle Aging. Role in Sarcopenia. Redox Signaling and Oxidative stress in Health and disease. IV Spanish and Portuguese meeting on Free radicals. June 2012. Valencia Spain

• Brioche T. , Pareja-GaleanoH. , Jovani C. , Montal MA, Sanchis-Gomar F. , Gomez- Cabrera MC, Martinez-Costa C. and Viña J. , Blood concentrations of neurotrophic factors at differents times during the season of Young high level cyclists. A possible marker of overtraining? International Symposium on learning, Memory and cognitive function. Mechanisms, Pathology and therapeutics. 2011, Valencia, Spain

• Galeano, Helios. Brioche Thomas. EXERCISE TRAINING IS ASSOCIATED WITH A PERIPHERAL INCREASE IN IGF-I AND BDNF IN TEENAGERS.

POSSIBLE ROLE OF CREB. Pareja- The 20

International Congress on Sport Science for Students. Semmelweis University. Budapest, Hungría. 26-28 Abril 2012.

• Pareja-Galeano, H.; Brioche T.; Sanchis-Gomar, F.; Martínez-Bello, V.;

Ferrando, B.; Garcia-Valles, R.; Gomez-Cabrera, MC. and Viña, J. EFFECTS OF EXERCISE TRAINING ON COGNITIVE DEFICITS AND BIOLOGICAL ALTERATIONS IN AN APP/PSN1 TRANSGENIC MICE MODEL FOR ALZHEIMER´S DISEASE. SFRR-Europe Summer School 2012. Dietary factors and redox signalling. Spetses. Grecia. 24-30 Septiembre 2012.

• H Pareja-Galeano, T Brioche, VE Martínez-Bello, B Ferrando, R García-Vallés, E García-López, S Ibáñez-Sania, F Sanchis-Gomar, I Noguera, MC Gómez-Cabrera and J Viña EXERCISE TRAINING AS A THERAPEUTIC STRATEGY FOR ALZHEIMER’S DISEASE IN A APPSWE,PSEN1DE9-TRANSGENIC MICE MODEL.VI Congreso International de la Asociacion Española de Ciensias Del Deporte, Elche, 2010

• Pareja-GaleanoH. , Brioche T. , Jovani C. , Montal MA, Sanchis-Gomar F. , Gomez- Cabrera MC, Martinez-Costa C. and Viña J. , Exercice Training is associated with a peripheral increase in neurotrophic factors in teenagers. Possible Role of CREB.

International Symposium on learning, Memory and cognitive function. Mechanisms, Pathology and therapeutics. 2011, Valencia, Spain

• Mari Carmen Gomez Cabrera, H. Pareja-Galeano, T. Brioche, V.E. Martinez-Bello, B.

Ferrando, Rebeca Garcia Valles, Jose Viña Ribes, Effects of exercise on cognitive alterations and oxidative stress in a double transgenic mice model for alzheimer’s disease. 53 Congreso de la Socidedad Espanola de Geriatria y Gerontologia 2011, Malaga (Spain), (Best Poster Award)

• Ferrando B., Puchades C., Derbre F., Brioche T., Pareja-Galeano H., Garcia- Valles

R., Cabo H., Diaz A., Cerda-Nicolas M., Comez-Cabrera Mc., Vina J. ROLE OF IKK-Α IN SKELETAL MUSCLE ATROPHY CAUSED BY HINDLIMB

UNLOADING IN MICE.REDOX SIGNALING AND OXIDATIVE

STRESS IN HEALTH AND DISEASE. International symposium. Valencia 2012

• G. Olaso, B. Ferrando, F. Derbre, R. García, V.E. Martínez-Vello, F. Sanchis-

Gomar, H. Pareja-Galeano, T. Brioche y J. Viña. BENEFICIOS DE LA

ADMINISTRACIÓN DE ALOPURINOL EN LA PÉRDIDA DE MASA

MUSCULAR CAUSADA POR INMOVILIZACIÓN. 5ª Reunión Nacional de la

Sociedad Española de Medicina Geriátrica. Toledo, España. 12-13 Abril 2012.

• R. García, D. Monleón, J.M. Morales, H. Pareja-Galeano, T. Brioche, B. Ferrando, A.

Díaz, I. Noguera, M.C. Gómez-Cabrera y J. Viña.EL EJERCICIO ESPONTANEO DURANTE 20 MESES INDUCE CAMBIOS METABÓLICOS EN RATONES C57BL/6J. 5ª Reunión Nacional de la Sociedad Española de Medicina Geriátrica.

Toledo, España. 12-13 Abril 2012.

• Ferrando,B., Derbre,F., Martinez-Bello, V.E., Sanchis-Gomar,F., Garcia-Valles,R., Romagnoli,M., Garcia-Lopez, E., Ibañez-Sania,S,. Brioche,T., Escriva,C., Sebastia,V., Diaz,A., Pareja-Galeano,H., Gomez-Cabrera,M.C., y Viña, J. Allopurinol prevents the loss of muscle mass induced by hindlimb unloading.molecular mechanisms. VI Congreso International de la Asociacion Española de Ciensias Del Deporte, Elche, 2010

• Mari Carmen Gomez Cabrera, Frédéric Derbré, Vladimir Essau Martinez Bello, Fabian Sanchiz Gomar, Rebecca Garcia Valles, Sandra Ibanez Sania, Thomas Brioche, Beatriz Ferrando, Gloria Olaso Gonzales, Helios Pareja Galeano, Arlette Gratas Delamarche, Jose Vina. Age associated low mitocondrial biogénesis may be explained by a lack of reponse of PGC-1α to exercise. SFRR - Europe 2011 Meeting, Istanbul. Turkey

• Gomez-Cabrera MC, Ibanez-Sania S, Sanchiz-Gomar F, Martinez-Bello VE, Diaz A, Olaso-Gonzalez G, Ferrando B, Brioche T, Pareja-Galeano H, Garcia-Valles R, Vina J, Regulation of the p53 Protein levels by aerobic training. Protective effect of exercise on paraquat-induced toxicity.Second International Conference on Environmental Stressors in Biology and Medicine, October 2011, Siena, Italy

RESEARCH AWARDS

Best Poster Award of the 53 Congreso de la Socidedad Espanola de Geriatria y Gerontologia 2011, Malaga (Spain),

OTHER ACHIEVEMENTS

Degree in animal experiments. Level 1. Veterinary School of Nantes. (2011)