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The Reprimo Gene Family: A Novel Gene Lineage in Gastric Cancer with Tumor Suppressive Properties

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Academic year: 2020

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Figure

Figure 1. Cont.
Figure 2. Evolution and diversification of RPRM genes in vertebrates. (A) During the diversification  of vertebrates RPRM genes were differentially retained, as not all RPRM genes are present in all main  groups of vertebrates
Figure 3. RNA expression of RPRM and RPRML across different tissues. (A) Tissue-specific expression  profile from 570 human donors available in the Genotype-Tissue Expression (GTEx) database [28]
Figure 4. Schematic model of RPRM-mediated cell cycle and G2 arrest mechanisms. RPRM has been  identified as a transcriptional target for: (1) p53 [4]; (2) histone deacetylase 7/FoxA1 (HDAC7/FoxA1)  in an estrogen mediated mechanism [49]; and (3) for epige
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