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FGF 1 induces ATP release from spinal astrocytes in culture and opens pannexin and connexin hemichannels

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Academic year: 2020

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Figure

Fig. 1. FGF-1 –induced permeabilization of spinal astrocytes is at first mediated by opening of Px HCs; then Cx HCs contribute
Fig. 2. FGF-1–induced permeabilization of spinal astrocytes depends on the expression of both Px1 and Cx43
Fig. 4. FGF-1 initially causes ATP release by a vesicular mechanism as indicated by sensitivity to botulinum neurotoxin A (BoNT A)
Fig. 5. Proposed reactions initiated by FGF-1. (i) FGF-1 binds to its (dimeric) receptor, likely causing a rise in cytoplasmic Ca 2+

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