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Atomic level characterization and cilostazol affinity of poly(lactic acid) nanoparticles conjugated with differentially charged hydrophilic molecules

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Academic year: 2020

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Figure 1: Schematic representation of PLA core formation process. Ball and stick representation of A) lactic acid monomer unit and atom definition for polymeric chain formation, B) poly(D,L-lactic acid) 20 monomer structure and C) van der Waals representat
Figure 2: Evaluation of optimal separation distance between PLA chains. The energy was evaluated for two 20-monomer PLA chains at 3, 4, 5, 6, 7, 8, 9 and 10 Å.
Figure 4: Schematic representation of the initial structure for DSPE–PEG coating process
Figure 6: A) 2D structure of cilostazol. B) Main putative binding sites of cilostazol docked into the PLA core
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