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Chemoenzymatic synthesis of optically active 2 (2 or 4 substituted 1H imidazol 1 yl)cycloalcanols Chiral additives for (L) proline

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Figure

Table 1 Synthesis of racemic alcohols 3a–e and 4a–e
Table 2 Lipase catalyzed kinetic resolution of racemic alcohols trans-3a–e and trans-4a–e
Fig. 2 Kinetic profile for the aldol reaction (a) red triangles: 1 : 1 ratio 4a : ( L )-proline; (b) black dots: absence of 4a

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