Differential Plasma-cell evolution is linked with Dermatophagoides pteronyssinus immunotherapy response.

Ultimately, further rounds of proliferation, SHM and selection will lead higher affinity variants to terminally differentiate into memory B cells or antibody secreting plasma cells

(B–F) qPCR of miRNAs and immunoblot of PKCz in SW480 shNT and shPKCz cells, n = 4 biological replicates (B); SW480 and SW620 cells, n = 4 biological replicates (C); WT and PKCz

In support of this, we have demonstrated that only erythropoiesis is severely affected in Rpl11 +/lox adult mice, while hematopoietic stem cells, progenitors and lymphopoiesis (B

mice after a second antigen challenge (Figure R13C). c-Myc-deficient B cell do not generate B220 lo Synd-1 + cells or GC B cells after immunization. A) Flow cytometry

We found that c-Myc is essential from early stages of B lymphocyte differentiation in vivo, and regulates this process by providing B cell identity via direct

reinhardtii after 1, 24 and 72 h of exposure to SPION as measured by flow cytometry using different fluorochromes: (A) plasma membrane potential, (B) mitochondrial membrane

Intriguingly, the loss of more than 20,000 CTCF binding sites results in a relatively mild gene expression phenotype, which has been previously discussed [19]. One of the hypothesis

Here we demonstrate for the first time that high levels of GSDMB gene, but not the other GSDM members, are associated to poor prognosis (in terms of disease-free and