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Modulación del procesamiento de la proteína precursora del amiloide por la tirosina quinasa C ABL y su implicancia en la enfermedad de Niemann Pick tipo C /

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Academic year: 2020

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Figure

Figure  1.  Sequential  cleavage  of  the  amyloid  precursor  protein  (APP)  occurs by two alternative pathways
Figure 1. CHO NPC models show increased APP processing through the  β-secretase  pathway
Figure  2.  c-Abl  inhibition  decreases  β-secretase  cleaved  APP  and  increases sAPPα levels in a cellular NPC model
Figure 3. Imatinib treatment decreases β-secretase cleavage products  in an NPC animal model
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