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TítuloNext generation sequencing and quantitative proteomics of Hutchinson Gilford progeria syndrome derived cells point to a role of nucleotide metabolism in premature aging

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Academic year: 2020

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Figure

Fig 1. Parallel genomic and proteomic workflows. Schematic representation of the workflow followed for the genomic (left) and proteomic (right) large-scale approaches
Fig 2. Transcripts and proteins significantly modulated in HGPS-derived cells versus healthy parental control cell lines.
Table 1. Crosschecking of the RNAsec and ITRAQ data.
Fig 4. Targeted validation of PRPS1 shows down-regulation of transcript and protein levels in HGPS-cells and the animal model of HPGS, respectively.
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