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Determination of esomeprazole in rabbit plasma by liquid chromatography-mass spectrometry and its application to a pharmacokinetic study

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167 ISSN 0326-2383

KEY WORDS:Esomeprazole, LC-MS, Pharmacokinetics, Rabbit plasma.

* Author to whom correspondence should be addressed. E-mail:[email protected]

Latin American Journal of Pharmacy

(formerly

Acta Farmacéutica Bonaerense)

Lat. Am. J. Pharm.

31

(1): 167-71 (2012)

Short Communication Received: January 19, 2012 Revised version: January 31|, 2012 Accepted: February 3, 2012

Determination of Esomeprazole in Rabbit Plasma

by Liquid Chromatography-Mass Spectrometry

and its Application to a Pharmacokinetic Study

Xueli HUANG

1

, Yuan ZHANG

2

, Yuancai ZHENG

3

, Zhisheng XU

4

,

Meiling ZHANG

2

, Mingjie DENG

2

, Zhiyi WANG

3

, & Xuebao WANG

2

*

1

School of Pharmacy,

2

Analytical and Testing Center,

3

The First Affiliated Hospital,

and

4

The Second Affiliated Hospital of Wenzhou Medical College, Wenzhou 325035, China.

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