Chemical composition and anti-inflammatory activity of the essential oil of Schinus terebinthifolius Raddi (Anacardiaceae) fruits

1555 ISSN 0326-2383

KEY WORDS: Anacardiaceae, Inflammation, Pink pepper, Schinus terebinthifolius.

* Author to whom correspondence should be addressed. E-mail: [email protected]

Latin American Journal of Pharmacy

(formerly

Acta Farmacéutica Bonaerense)

Lat. Am. J. Pharm.

30

(8): 1555-9 (2011)

Regular Article Received: June 1, 2011 Revised version: July 19, 2011 Accepted: July 20, 2011

Chemical Composition and Anti-Inflammatory Activity of the

Essential Oil of

Schinus terebinthifolius

Raddi (Anacardiaceae) Fruits

Anelise S. NAZARI FORMAGIO

_{, Edna K. KASSUYA IRIGUCHI}

_{, Liriana M. ROVEDA}

_,

Maria do C. VIEIRA

_{, Claudia A. LIMA CARDOSO}

_{, Nestor A. HEREDIA ZARATE}

_,

Luciane A. TABALDI

_{& Cândida A. LEITE KASSUYA *}

1

_{Faculdade de Ciências Agrárias,}

_{Faculdade de Ciências da Saúde,}

Universidade Federal da Grande Dourados, Dourados, MS, Brazil.

3

_{Curso de Química, Universidade Estadual de Mato Grosso do Sul, Dourados, MS, Brazil.}

_{Department of Pharmacology, Universidade Federal do Paraná, Curitiba, PR, Brazil}

SUMMARY. Traditional usage ofSchinus terebinthifoliusRaddi, popularly known as Brazilian pepper, in-cludes the treatment of inflammatory diseases. Chemical composition of the essential oil extracted of fruits of S. terebinthifoliuscollected in Mato Grosso do Sul was investigated and the anti-inflammatory activity was evaluated. The essential oil (EOST) obtained in Clevenger and analyzed by GC-MS, exhibited pre-dominance of monoterpenes. The oral administration of EOST significantly inhibited, in dose dependent manner, the carrageenan (Cg) induced rat paw oedema. The observed inhibitions after two hours of Cg-injection were 57 ± 8 % (100 mg kg–1_{) for EOST and 66 ± 6 % for dexamethasone (DEXA). In another}

model of inflammation, the oral administration of EOST (100 mg kg–1_{) reduced 56 ± 11 % while DEXA}