Floating gellan-chitosan polyelectrolyte complex beads: effect of gelucires incorporation on encapsulation efficiency and drug release

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37 ISSN 0326-2383

KEY WORDS: Complex coacervation, Emulsion beads, Floating drug delivery, Gellan-chitosan beads, Gelucire, Metronidazole, Polyelectrolyte complex.

* Author to whom correspondence should be addressed.E-mail: anuragverma_iftm@yahoo.co.in

Latin American Journal of Pharmacy

(formerly

Acta Farmacéutica Bonaerense)

Lat. Am. J. Pharm.

31

(1): 37-42 (2012)

Regular Article Received: September 27, 2011 Revised version: December 25, 2011 Accepted: January 6, 2011

Floating Gellan-Chitosan Polyelectrolyte Complex Beads: Effect of

Gelucires Incorporation on Encapsulation Efficiency and Drug Release

Raghav DIXIT

1

, Anurag VERMA *

1

, Arun K MISHRA

1

, Navneet VERMA

1

& Jayanta K. PANDIT

2

1

Department of Pharmaceutics, School of Pharmaceutical Sciences,

IFTM University, Moradabad, 244001, India

2

Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi, India

SUMMARY. The purpose of the present investigation is to study the effect of incorporation of gelucire 39/01 and 50/13 on encapsulation efficiency and release of water soluble drug (metronidazole, log P = 0.0) from floating gellan-chitosan polyelectrolyte complex (PEC) beads. Floating emulsion PEC beds were pre-pared in one step without using any chemical crosslinker. Briefly, an emulsion of gellan gum (GG) with gelucire 39/01 and 50/13 containing CaCO3and drug was extruded dropwise into low molecular weight

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