• No se han encontrado resultados

In vitro transcutaneous permeation of acyclovir sodium from HPMC gels: role of chemical permeation enhancers

N/A
N/A
Info
Descargar
Protected

Academic year: 2017

Share "In vitro transcutaneous permeation of acyclovir sodium from HPMC gels: role of chemical permeation enhancers"

Copied!
1
0
0

Cargando.... (Ver texto completo ahora)

Descargar ahora ( 1 página )

Texto completo

(1)

861 ISSN 0326-2383

KEY WORDS:Acyclovir sodium, Flux, gels, Hydroxypropylmethylcellulose, Permeation enhancers. * Author to whom correspondence should be addressed.E-mail: jukantiraj@gmail.com

Latin American Journal of Pharmacy

(formerly

Acta Farmacéutica Bonaerense)

Lat. Am. J. Pharm.

29

(6): 861-8 (2010)

Original Article

Received: November 3, 2009 Accepted: December 24, 2009

In Vitro

Transcutaneous Permeation of Acyclovir Sodium

from HPMC Gels: Role of Chemical Permeation Enhancers

Ashok MATETI, Raju JUKANTI *, Suresh BANDARI & Prabhakar R. VEERAREDDY

Department of Pharmaceutics, St. Peter’s Institute of Pharmaceutical Sciences,

Vidyanagar, Hanamkonda, Warangal (A.P.) 506001, India.

SUMMARY. The main objective of the present study is to improve the permeation of acyclovir sodium (ACV) across stratum corneum (SC) from HPMC gel formulations. We have also investigated the role of chemical permeation enhancers like dimethyl sulfoxide, ethanol, limonene and sodium taurodeoxycholate on the transcutaneous permeation of ACV from HPMC gels. The optimized formulations were character-ized and subjected to in vitropermeation study using excised rat abdominal skin. The histological exami-nation of the skin was studied to understand the mechanisms involved in the permeation of ACV across skin. The cumulative amount of ACV permeated and the increase in permeation parameters (Jss, Kp and

Referencias

Descargar ahora ( PDF - 1 página - 35.41 KB )

Documento similar

ON THE MEASURES TAKEN IN THE EU MEMBER STATES AS A RESULT OF THE COVID-19 CRISIS

In the preparation of this report, the Venice Commission has relied on the comments of its rapporteurs; its recently adopted Report on Respect for Democracy, Human Rights and the Rule

HAGARISM THE

The Dome of the Rock does attest the existence, at the end of the seventh century, of materials immediately recognisable as Koranic in a text that not infrequently

ARTICLE IN PRESS

The Conference of Directors and Deans of Chemical Engineering (CODDIQ, www.coddiq.es) was created on 12 May 2008 with the aim of meeting a number of objectives, ranging from

Adolescents: The Role of Impulsivity and Sensation Seeking

Consequently, the aim of this research was, on the one hand to analyze the direct association of impulsivity and sensation seeking scales (thrill and adventure seeking,

ROLE OF THE VOMERONASAL INPUT IN MATERNAL BEHAVIOR

This hypothesis was based on the following rationale: (1) The ontogenetic period for BDZ central receptors extend from prenatal days 13 – 14, in which only 35% of adult levels

of The

Parameters of linear regression of turbulent energy fluxes (i.e. the sum of latent and sensible heat flux against available energy).. Scatter diagrams and regression lines

The emergence of objects from mathematical practices

In addressing these questions we first explore why mathematics is presented to students in a realist way. Then, in Section 3, the paper considers whether teaching

Role of brown adipose tissue in the

correlations of number of hours per day at a certain temperature measured by wrist skin temperature (WT) and Personal- environmental temperature (ET) with 18F- FDG uptake by