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Effect of citric acid and polymer blend on characteristics of ofloxacin floating matrix tablets by factorial design

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45 ISSN 0326-2383

KEY WORDS: Ofloxacin, Floating matrix, Citric acid, HPMC, SCMC, Factorial design.

* Author to whom correspondence should be addressed. E-mail:mandalbivash@yahoo.com

Latin American Journal of Pharmacy

(formerly

Acta Farmacéutica Bonaerense)

Lat. Am. J. Pharm. 30

(1): 45-52 (2011)

Original Article Received: November 21, 2009 Revised version: April 21, 2010 Accepted: April 25, 2010

Effect of Citric Acid and Polymer Blend on Characteristics

of Ofloxacin Floating Matrix Tablets by Factorial Design

Hriday BERA, Bivash MANDAL*, Chandrima SINHA, Sanjoy K DEY,

Rammohan BERA & Lakshmi K GHOSH

Pharmaceutics Research Lab-II, Department of Pharmaceutical Technology,

Jadavpur University, Kolkata-700032, West Bengal, India

SUMMARY. The present investigation deals with the development of floating matrix tablet containing Ofloxacin, to prolong the gastric residence time, thereby effective in eradication of Helicobacter pylori from the gastric mucosa. A 32factorial design was employed to formulate floating matrix tablet selecting

polymer blend ratio [hydroxypropyl methylcellulose (HPMC) / sodium carboxymethylcellulose (SCMC)] and content of citric acid as independent variables. Time required for 50 % of drug release (t50 %),

per-centage drug release at 8 h (Q8), floating duration (h) and diffusion exponent (n) were selected as

depen-dent variables. Multiple regression analysis with two way ANOVA revealed statistically significant effect of the two independent variables on the responses studied (P < 0.01). Floating duration varied from 7.5 h to 20 h, Q8varied from ~ 76 % to ~100 % whereas t50 %ranged from 1.7 h to 3.7 h. The kinetics of drug

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