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Pharmacokinetics, tissue distribution, excretion, and metabolism of a novel antitumor agent, gambogenic acid, in rats

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514 ISSN 0326-2383

KEY WORDS: Excretion, Gambogenic acid, Metabolism, Pharmacokinetics, Tissue distribution.

* Author to whom correspondence should be addressed. E-mail: wdl8105@126.com

Latin American Journal of Pharmacy

(formerly

Acta Farmacéutica Bonaerense)

Lat. Am. J. Pharm. 31

(4): 514-9 (2012)

Regular Article Received: October 31, 2011 Revised version: May 8, 2012 Accepted: May 9, 2012

Pharmacokinetics, Tissue Distribution, Excretion, and Metabolism

of a Novel Antitumor Agent, Gambogenic Acid, in Rats

Dianlei WANG

1,2

,*, Rui ZHANG

2

, Daiyin PENG

2

, Weidong CHEN

1,2

,

An ZHOU

2

, Xiaoshan WANG

2

, & Qinglin LI

2

1

Laboratory of Drug Metabolism and Pharmacokinetics,

Anhui University of Traditional Chinese Medicine, 230038 Hefei, China

2

Anhui Province Key Laboratory of R&D of Chinese Medicine, 230038 Hefei, China

SUMMARY. The plasma pharmacokinetics, tissue distribution, excretion, and metabolism of gambogenic acid (GNA), potential antitumor candidate, were investigated in rats. GNA showed linear pharmacokinet-ic characteristpharmacokinet-ics in rats within the test dose (1, 2, and 4 mg/kg). The t1/2βwas 40.38-41.16 min. GNA

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