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TítuloBiological influence of Hakai in cancer: a 10 year review

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Academic year: 2020

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Figure

Fig. 1. Posttranslational mechanism to donwregulate E-cadherin at AJ by Hakai. a Epithelial phenotype
Fig.  2.  A  schematic  domain  structure  of  c-Cbl  and  Hakai  proteins.  a  Domain  structure  of  c-Cbl  protein  contain  a  phophotyrosin-binding domain (pTyr-B), a RING-finger domain, a proline-rich region, and a lucine zipper (Leu-Z) domain
Fig. 3. Hakai upstream signaling pathways. a Ca 2+  depletion activate Cdc42 to initiate activation of EGFR and Src, which in  turn phosphorylate E-cadherin, leading Hakai-mediated E-cadherin ubiquitination and degradation

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