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A novel pharmacodynamic assay to evaluate the effects of crystallization inhibitors on calcium phosphate crystallization in human plasma

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Academic year: 2020

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Table 1.  Intra-day and inter-day precision of the spectrophotometric assay evaluated by determining the  average coefficients of variation (CV)
Figure 3.  Dilution ability of SNF472 in plasma samples that are above the upper limit of the calibration curve  and stability in plasma samples under different storage and temperature conditions
Table 2.  Intra-day and inter-day precision of the spectrophotometric assay in determining the efficacy of  SNF472 in inhibiting crystallization of calcium phosphate in human plasma
Figure 4.  Preclinical validation of the efficacy of crystallization inhibition in rat plasma samples with different  concentrations of SNF472 added in vitro or in vivo and SNF472 plasma levels after 20 min of subcutaneous  administration
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