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Cocaine Effects on Dopaminergic Transmission Depend on a Balance between Sigma 1 and Sigma 2 Receptor Expression

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FIGURE 1 | Expression of σ 2 R-containing heteromer complexes in a heterologous expression system
FIGURE 2 | Identification of D 1 R- σ 1 R- σ 2 R heteromers in a heterologous expression system
FIGURE 3 | σ 2 R modulation of D 1 receptor-mediated signaling in a heterologous expression system
FIGURE 4 | Cocaine effects on D 1 R-mediated signaling. MAP kinase activation was determined in HEK-293T cells transfected with 0.75 µg cDNA for D 1 R in the absence (C) or presence of 3 µg siRNA for σ 1 R (A), 3 µg siRNA for σ 2 R (B) or both (D)
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