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Effect of hypoxia in skeletal muscle fibrosis : regulation of CTGF/CCN2 expression by HIF 1α and TGF β

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Academic year: 2020

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Figure  1.  Fibrosis  in  skeletal  muscles  from  mdx  dystrophic  mice.  Microscopic  images  of  muscles from wild type and mdx show the fibrotic phenotype
Figure 3120 37 50  -CCN2 cel.TubulinHIF-1αCTRLTGF-β1 HYPHypoxia + TGF-β10.0010.010.110.0010.010.1137 - CCN2 sec.(ng/mL)kDa
Table 1. Transcription factor binding sites in CTGF/CCN2 mouse promoter
Figure  4.  Proposed  cellular  model:  “Vicious  oxygen  cycle”.  A.  Initially,  in  physiological  conditions the oxygen flow freely through blood vessels to muscle cells

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