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Isolation, identification and determination of the mayor degradation product in alprazolam tablets during their stability assay / A L Huidobro, F J Rupérez and C Barbas

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Academic year: 2020

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Fig. 1. Chromatogram showing alprazolam tablet coming from the stability assay after 6 months storage at 40 ◦ C/75%HR and UV spectrum of the impurity
Fig. 2. Chromatograms corresponding to the accelerated degradation study: Excipients and the tablet corresponding to 0.25 mg dose before (continuous lines) and after treatment: 105 ◦ C for 6 h in a closed container with water in the bottom (discontinuous l
Fig. 4. (a) Chromatogram showing the semi-preparative HPLC separation of the solution obtained from the dried extract coming from the SPE; (b) chromatogram of the isolated degradation product analyzed with the analytical HPLC method.
Fig. 5. MS (top) and MS/MS (bottom) spectrums. For chromatographic and mass spectrometry conditions see Section 2.
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