Synthetic tambjamine analogues induce mitochondrial swelling and lysosomal dysfunction leading to autophagy blockade and necrotic cell death in lung cancer

Resveratrol Prevents Right Ventricle Remodeling and Dysfunction in Monocrotaline- Induced Pulmonary Arterial Hypertension with a Limited Improvement in the Lung

CHCHD3 silencing in primary CD8 + T cells recapitulated some effects induced by PD-1 stimulation, including reduced mitochondrial polarization and interferon- γ production following

In addition, in db/db mice, inhibition of TLR4/NF-κB signaling prevented the decreased kidney PGC-1α expression, mitochondrial dysfunction and deformation, and ROS accumulation,

In a model of SARS-CoV infection, the blockade of AT1 receptors revealed itself effective in attenuating pulmonary oedema and severe lung injury (3). In addition to attenuating

13,14 To analyze the antioxidant capacity of nitrones 4 and explore whether ROS could be involved in their neuroprotective actions, ex vivo experiments were carried out, following

[r]

To explore this possibility, we loaded re-plated PDAC2-derived spheres and PDAC2 adherent cell populations with AO and observed a clear increase in lysosomal mass in

Natural sources of TWEAK in the prostate may include leukocytes. Thus, T cells express an array of lethal cytokines, such as TRAIL and TWEAK that are functional in target cell