Ficha del Directorio
Ficha de investigador
FERMÍN SÁNCHEZ DE MEDINA LOPEZ
HUERTAS
Grupo de Investigación: FARMACOLOGIA DE PRODUCTOS NATURALES (Cod.: CTS164) Departamento: Universidad de Granada. Farmacología
RG: https://www.researchgate.net/profile/Fermin_Sanchez_de_Medina Correo electronico: fsanchez@ugr.es
Código: 20715
Producción 103
Artículos (74)
Libros (1)
Capítulos de Libros (14)
Tesis dirigidas (14)
Proyectos dirigidos 11
Proyectos (6)
Contratos (5)
Convenios (0)
Actividades 18
Evolución producción Tesis Capítu… Libros Artículos 1993 1995 1997 1999 2001 2003 2005 2007 2009 2011 2013 2015 2017 0 4 8 12 16 AñoProyectos en curso por año
A synbiotic composed of lactobacillus fermentum cect5716 and fos prevents the development of fatty acid liver and glycemic
alterations in rats fed a high fructose diet associated with changes in the microbiota
Molecular nutrition and food
research Articulo 2017
Chemical composition and immuno-modulatory effects of urtica
dioica l. (stinging nettle) extracts Phytotherapy research Articulo 2017 Estudio de la función inmunológica de la fosfatasa alcalina no
específica de tejido Universidad de granada.facultad de farmacia Tesisdoctoral 2017 Effect of ahcc on gastrointestinal dysfunction Clinician¿s guide to ahcc. Capítulode libro 2016 Fructooligosaccharides exert intestinal anti-inflammatory activity in
the cd4+ cd62l+ t cell transfer model of colitis in c57bl/6j mice European journal of nutrition Articulo 2016 Germ-free and antibiotic-treated mice are highly susceptible to
epithelial injury in dss colitis Journal of crohn'sand colitis Articulo 2016 Obesidad, hiperleptinemia e inflamación intestinal: estudios en
modelos animales. Tesisdoctoral 2016
The bisphosphonate pamidronate is an intestinal antiinflammatory agent in rat and mouse experimental colitis.
Inflammatory bowel
diseases Articulo 2016
The glucocorticoid budesonide has protective and deleterious effect
in experimental colitis Biochemical pharmacology Articulo 2016 Tissue nonspecific alkaline phosphatase expression is needed for
the full stimulation of t cells and t cell dependent colitis
Journal of crohn's
and colitis Articulo 2016 Intestinal anti-inflammatory activity of apigenin k in two rat colitis
models induced by trinitrobenzenesulfonic acid and dextran
sulphate sodium British journal of nutrition Articulo 2015
Modulación ejercida por los glucocorticoides sobre la función de
barrera intestinal Universidad de granada.facultad de farmacia Tesisdoctoral 2015 Nonprebiotic actions of prebiotics Probiotics, prebiotics andsynbiotics. bioactive foods
in health promotion. Capítulo de libro 2015 Psoriasis Actualizaciones farmacológicas en dermatología Capítulo de libro 2015 The small intestinal mucosa acts as a rutin reservoir to extend
flavonoid anti-inflammatory activity in experimental ileitis and colitis Journal of functional foods Articulo 2015 Active hexose correlated compound exerts therapeutic effects in
lymphocyte driven colitis. Molecular nutrition and foodresearch Articulo 2014 Estudio del efecto directo, independiente de su efecto prebiótico, de
oligosacáridos no digeribles sobre células de la mucosa intestinal Tesisdoctoral 2014 Food derived bioactive peptides and the intestinal barrier function. International journal ofmolecular sciences Articulo 2014 Fructooligosacharides reduce pseudomonas aeruginosa pao1
pathogenicity through distinct mechanisms. Plos one Articulo 2014 Mecanismo molecular y farmacocinético del efecto de los
flavonoides en inflamación intestinal.
Tesis
doctoral 2014 Nondigestible oligosaccharides exert nonprebiotic effects on
intestinal epithelial cells enhancing the immune response via activation of tlr4-nf¿b
Molecular nutrition and food
research Articulo 2014
Prebiotic oligosaccharides directly modulate proinflammatory
cytokine production in monocytes via activation of tlr4 Molecular nutrition and foodresearch Articulo 2014 Rutin has intestinal antiinflammatory effects in the cd4+ cd62l+ t
cell transfer model of colitis. Pharmacological research Articulo 2014
Stain-free detection as loading control alternative to ponceau and
housekeeping protein immunodetection in western blotting. Analytical biochemistry Articulo 2014 Validation of bovine glycomacropeptide as an intestinal
anti-inflammatory nutraceutical in the lymphocyte-transfer model of
colitis British journal of nutrition Articulo 2014
Active hexose correlated compound and bifidobacterium longum
bb536 exert symbiotic effects in experimental colitis. European journal of nutrition Articulo 2013 Dose-dependent antiinflammatory effect of ursodeoxycholic acid in
experimental colitis. Internationalimmunopharmacology Articulo 2013 Fxr-dependent and -independent interaction of glucocorticoids with
the regulatory pathways involved in the control of bile acid handling by the liver.
Biochemical pharmacology Articulo 2013 Implicación de la fosfatasa alcalina en la inflamación intestinal. Tesis
doctoral 2013 Modulation of ion transport in inflammatory bowel diseases:
regulatory targets
Tesis
doctoral 2013 Modulation of ion transport in inflammatory bowel diseases:
regulatory targets.
Tesis
doctoral 2013 New insights into the mechanism of prebiotics and microbiota on
the intestinal defense
Facultad de farmacia, universidad de granada
Tesis
doctoral 2013 The nutritional supplement active hexose correlated compound
(ahcc) has direct immunomodulatory actions on intestinal epithelial cells and macrophages involving tlr/myd88 and nf-¿b/mapk
activation.
Food chemistry Articulo 2013
Tratamiento de infecciones fúngicas
Actualización al tratamiento farmacológico de
enfermedades infecciosas
Capítulo de libro 2013 A porphyra columbina hydrolysate upregulates il-10 production in rat
macrophages and lymphocytes through an nf-kb, and p38 and jnk dependent mechanism.
Food chemistry Articulo 2012 Exogenous alkaline phosphatase treatment complements
endogenous enzyme protection in colonic inflammation and reduces
bacterial translocation in rats Pharmacological research Articulo 2012 Immunomodulatory properties of the protein fraction from phorphyra
columbina
Journal of agricultural and
food chemistry Articulo 2012 Sexual dimorphism in clock genes expression in human adipose
tissue. Obesity surgery Articulo 2012
Effects of flavonoids and other polyphenols on inflammation. Critical reviews in foodscience and nutrition Articulo 2011 Intestinal inflammation and the enterocyte transportome. Biochemical society
transactions Articulo 2011 Nueva percepción de los efectos inmunológicos de los péptidos
bioactivos alimenticios en modelos animales de inflamación intestinal
Inmuninutrición. en la salud y la enfermedad.
Capítulo de libro 2011 Persistent epithelial barrier alterations in a rat model of
postinfectious gut dysfunction. Neurogastroenterology andmotility Articulo 2011 Tissue nonspecific alkaline phosphatase is induced in stressed
enterocytes by changes in glycosylation. Inflammatory boweldiseases Articulo 2011 Antioxidantes e inflamación intestinal. Terapia nutricional en laenfermedad inflamatoria
intestinal.
Capítulo de libro 2010 Bovine glycomacropeptide has intestinal antiinflammatory effects in
Caracterización del efecto antiinflamatorio de los bisfosfonatos nitrogenados y su aplicación en la enfermedad inflamatoria intestinal.
Universidad de granada.
farmacología Tesisdoctoral 2010 Differences in ampk expression between subcutaneous and visceral
adipose tissue in morbid obesity Regulatory peptides Articulo 2010 Flavonoids exert distinct modulatory actions on cyclooxygenase 2
and nf-κb in iec18 cells
British journal of
pharmacology Articulo 2010 Functional nutrients and obesity Revista española de
obesidad Articulo 2010
It may not be not intestinal, but tissue nonspecific alkaline
phosphatase Gut Articulo 2010
New insights into the immunological effects of food bioactive
peptides in animal models of intestinal inflammation Proceedings of the nutritionsociety Articulo 2010 Reversible ponceau staining as a loading control alternative to actin
in western blots Analytical biochemistry Articulo 2010
The intestinal antiinflammatory agent glycomacropeptide has
immunomodulatory actions on rat splenocytes. Biochemical pharmacology Articulo 2010 Transtornos funcionales del aparato digestivo: dispepsia y
síndrome de intestino irritable
Actualización al tratamiento farmacológico de las patologías digestivas Capítulo de libro 2010 Vitaminas d
Tratado de nutrición, 2ª ed. tomo i. bases fisiológicas y bioquímicas de la nutrición.
Capítulo de libro 2010 Bovine glycomacropeptide induces cytokine production in human
monocytes through the stimulation of the mapk and the nf-kappab signal transduction pathways.
British journal of
pharmacology Articulo 2009 Genomic analysis of sulfasalazine effect in experimental colitis is
consistent primarily with the modulation of nf-kb but not ppar-g signaling
Pharmacogenetics and
genomics Articulo 2009
Ingredientes funcionales de naturaleza proteica, hidrocarbonada y derivados
Alimentos funcionales y salud en la etapa infantil y juvenil
Capítulo de libro 2009 Mecanismo de acción del glucomacropéptido bovino como agente
antiinflamatorio intestinal Universidad de granada. bioquímica y biología molecular Tesis doctoral 2009 New insights into the immunological effects of food bioactive
peptides in animal models of intestinal inflammation Proceedings of the nutritionsociety Articulo 2009 Tratamiento de las dislipemias Actualización al tratamientofarmacológico de las
patologías cardiovasculares
Capítulo de libro 2009 Bovine glycomacropeptide ameliorates experimental rat ileitis by
mechanisms involving downregulation of interleukin 17
British journal of
pharmacology Articulo 2008 Consejo farmacéutico: aterogénesis y trombogénesis. Sic formación s.l. Libros 2008 Disturbances in metabolic, transport and structural genes in
experimental colonic inflammation in the rat: a longitudinal genomic analysis
Bmc genomics Articulo 2008 Effect of flavonoids on rat splenocytes, a structure-activity
relationship study Biochemical pharmacology Articulo 2008
Enfermedad inflamatoria intetinal. Trastornos funcionales ymotores del aparato digestivo
Capítulo de libro 2008 Infecciones víricas del aparato respiratorio: resfriado y gripe.
Actualización al tratamiento farmacológico de las patologías respiratorias.
Active hexose correlated compound acts as a prebiotic and is anti
inflammatory in rats with hapten-induced colitis The journal of nutrition Articulo 2007 The bisphosphonate alendronate improves the damage associated
with trinitrobenzenesulfonic acid-induced colitis in rats. British journal ofpharmacology Articulo 2007 Flavonoides y enfermedad inflamatoria intestinal Ars pharmaceutica Articulo 2006 Goat milk oligosaccharides are anti-inflammatory in rats with
hapten-induced colitis The journal of nutrition Articulo 2006
Inhibition of pro-inflammatory markers in primary bone marrow-derived mouse macrophages by naturally occurring flavonoids: analysis of the structure-activity relationship
Biochemical pharmacology Articulo 2006 Relación estructura actividad de los flavonoides como agentes
antiinflamatorios intestinales
Universidad de granada. farmacología
Tesis
doctoral 2006 Bovine glycomacropeptide is anti-inflammatory in rats with
hapten-induced colitis The journal of nutrition Articulo 2005
Disturbances in epithelial ionic secretion in different experimental
models of colitis Life sciences Articulo 2005
Experimental inflammation of the rat distal colon inhibits ion secretion in the proximal colon by affecting the enteric nervous system
Naunyn-schmiedeberg's
archives of pharmacology Articulo 2005 Monochloramine induces acute and protracted colitis in the rat:
response to pharmacological treatment Life sciences Articulo 2005 Anti-inflammatory effect of diosmectite in hapten-induced colitis in
the rat
British journal of
pharmacology Articulo 2004 Induction of alkaline phosphatase in the inflamed intestine: a novel
pharmacological target for inflammatory bowel disease Biochemical pharmacology Articulo 2004 Alteraciones del transporte hidroelectrolítico en el modelo de colitis
experimental por tnbs
Universidad de granada. farmacología
Tesis
doctoral 2003 Efecto de la diosmectita en el modelo de colitis experimental
inducido por ácido trinitrobencenosulfónico en ratas
Universidad de granada. farmacología
Tesis
doctoral 2003 The intestinal anti-inflammatory activity of ur-12746s on reactivated
experimental colitis is mediated through downregulation of cytokine production.
Inflammatory bowel
diseases Articulo 2003
Disturbances of colonic ion secretion in inflammation: role of the
enteric nervous system and camp Pflugers archiv: europeanjournal of physiology Articulo 2002 Effect of quercitrin on the early stages of hapten induced colonic
inflammation in the rat Life sciences Articulo 2002
Dietary vitamin e supplementation protects the rat large intestine from experimental inflammation
International journal for vitamin and nutrition research
Articulo 2001
Effects of flavonoids on gastrointestinal disorders
Studies in natural product chemistry: bioactive natural products (part f)
Capítulo de libro 2001 Half-lives of plasma membrane na+/h+ exchangers nhe1-3: plasma
membrane nhe2 has a rapid rate of degradation. American journal ofphysiology: cell physiology Articulo 2001 Effect of polypodium leucotomos on acute, chronic and reactivated
trinitrobenzene sulphonic acid colitis in rats Inflammopharmacology Articulo 2000 Short-term regulation of nhe3 by egf and protein kinase c but not
protein kinase a involves vesicle trafficking in epithelial cells and fibroblasts.
Proceedings of the national academy of sciences of the united states of america
Articulo 2000 Development of an endogenous epithelial na+/h+ exchanger (nhe3)
in three clones of caco-2 cells The american physiologicalsociety Articulo 1999 Na+/h+ exchangers (nhe1-3) have similar turnover numbers but
Short-term regulation of nhe3 by growth factors/protein kinases involves vesicle trafficking in epithelial cells and fibroblasts.
Proceedings of falk symposium
Capítulo de libro 1999 Short-term regulation of nhe3 by growth factors/protein kinases
involves vesicle trafficking in epithelial cells and fibroblasts.
Proceedings of falk
symposium Articulo 1999
In birds, nhe2 is major brush-border na+/h+ exchanger in colon and is increased by a low-nacl diet
American journal of physiology-regulatory, integrative and comparative physiology
Articulo 1998 Oral administration of rutoside can ameliorate inflammatory bowel
disease in rats Life sciences Articulo 1998
Quantitative contribution of nhe2 and nhhe3 to rabbit ileal brush-border na+/h+ exchange
The american physiological
society Articulo 1998
Effects of quercetin on epithelial chloride secretion Life sciences Articulo 1997 Rutoside as mucosal protective in acetic acid- induced rat colitis Planta medica Articulo 1997 Effect of quercitrin on acute and chronic experimental colitis in the
rat
Journal of pharmacology and experimental
therapeutics Articulo 1996 Inhibitory effects of quercetin on guinea-pig ileum contractions Phytotherapy research Articulo 1996 Effect of quercitrin on lactose-induced chronic diarrhoea in rats. Planta medica Articulo 1994 Oral-administration of quercitrin modifies intestinal oxidative status
in rats General pharmacology Articulo 1994
Actividades 18
1 Regulacion de la funcion de barrera intestinal por corticoides, calprotectina, y elintercambiador sodio-hidrogeno nhe3 Proyecto 1/1/15 12/31/17 2 Importancia fisiopatológica de la mucosa intestinal como interfase transporteiónico-respuesta inmunológica. modulación por agentes farmacológicos. Proyecto 1/1/12 12/31/14 3 Bases biotecnológicas para el desarrollo de alimentos funcionales en el campo dela maduración intestinal, la enfermedad inflamatoria intestinal y el síndrome de
intestino irritable.
Proyecto 3/16/10 3/15/13 4 Senifood - investigación industrial de dietas y alimentos con características
específicas para las personas mayores Contrato 1/1/10 12/31/12 5 Investigación científica dirigida al desarrollo de una nueva generación de
alimentos para el control de peso y prevención de la obesidad (pronaos) Contrato 1/1/09 12/31/11 6
Caracterización de las alteraciones en el transporte epitelial intestinal en la enfermedad inflamatoria intestinal y modulación por agentes antiinflamatorios
experimentales. Proyecto 1/1/09 12/31/11
7 Synergistic intestinal antiinflammatory effects of active hexose correlatedcompound with probiotics Contrato 3/1/10 8/31/10 8 Effects of active hexose correlated compound on lamina propria and mesentericnode mononuclear cells. Contrato 6/1/08 12/31/09 9 Caracterización del efecto antiinflamatorio intestinal y antihiopertensivo delglucomacropéptido. Proyecto 1/1/06 12/30/08 10 Determinación de la translocación bacteriana en cámara de ussing. Contrato 6/20/04 12/19/04 11 Relación estructura actividad de los flavonoides como agentes antiinflamatorios Proyecto 6/1/03
Colaboradores
OLGA MARTINEZ AUGUSTIN
(69)
MARIA DOLORES SUAREZ ORTEGA
(42)
JULIO JUAN GÁLVEZ PERALTA
(20)
RAQUEL GONZÁLEZ PEREZ
(18)
ROCÍO LÓPEZ POSADAS
(16)
Borja Ocón Moreno
(10)
Evaluación de artículos para revistas Experiencia enevaluación Jan 1,2003
Evaluación de proyectos Experiencia enevaluación Oct 15,1996
Evaluador de la shota rustaveli national science foundation de georgia Experiencia enevaluación Dec15, 2011 Evaluador del health research board de irlanda Experiencia en
evaluación
Jan 12, 2009 Evaluador de la agencia nacional de promoción científica y tecnológica de la
república argentina
Experiencia en evaluación
Sep 2, 2007 Evaluador del broad medical research program Experiencia en
evaluación
Apr 16, 2007 Evaluador de la international foundation for science Experiencia en
evaluación
Jan 15, 1997
Isrn nutrition Comitéscientíficos de
revista
Jun 12, 2012 Miembro del consejo editorial del world journal of gastroenterology 2014-2017
Comités científicos de revista
Apr 19, 2011 Evaluador para el government of the hong kong special administrative region
(hksar)
Experiencia en evaluación
Jun 18, 2015 Evaluador para la executive agency for higher education, research,
development and innovation funding de rumanía Experiencia enevaluación Jan 3,2012 Miembro de la sociedad española de farmacología Comité científicoen sociedad ci Jul 7,2004 Participación en: red española reit de transporte () Comité científicoen sociedad ci Jan 1,2006 Participación en: ibdnet () Comité científicoen sociedad ci Jan 1,2006 Participación en: ciberehd - centro de investigación biomédica en red en
enfermedades hepáticas y digestivas () Comité científicoen sociedad ci Jun 1,2007 Participación en comité de revista: world journal of pharmacology Comitéscientíficos de
revista
Apr 1, 2011 Participación en comité de revista: international journal of pharmacology
Comités científicos de revista
Jan 1, 2004 Participación en comité de revista: pharmacological research Comitéscientíficos de
revista
Jan 1, 2009
