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New clicked thiirane derivatives as gelatinase inhibitors : the relevance of the P1? segment / J M Zapico [et al ]

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Figure

Figure  1.  Proposed  mechanism  for  the  slow  inhibition  of  MMPs  by  SB-3CT.  The  catalytic  Glu404  removes  a  proton  from  the  inhibitor,  leading  to  the  opening  of  the  thiirane  ring
Figure 2. Click-chemistry approach for the synthesis of 2.
Figure 3. Clicked-thiiranes synthesized by Mobashery et al. 25 Binding to MMP-2: NMR and computational studies
Figure 5. Most energetically favoured binding modes for (E)-7f  (A)  and  (Z)-7f  (B)  in  MMP-2
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