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Matrix Metalloproteinase 2 deficient Fibroblasts Exhibit an Alteration in the Fibrotic Response to Connective Tissue Growth Factor/CCN2 because of an Increase in the Levels of Endogenous Fibronectin

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Academic year: 2020

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FIGURE 2. CTGF decreases the amount of fibronectin in 3T3 cells treated with GM-6001. A, fibroblasts were incubated for 24 h with different  concen-trations of CTGF in serum-free medium in the presence of 25 ␮ M GM-6001.
FIGURE 5. CTGF interacts with fibronectin without degrading it. A, the interaction between CTGF and FN was evaluated using solid phase binding assay as explained under “Experimental Procedures.” The binding analysis was carried out using three concentratio
FIGURE 9. CTGF decreases the amount of FN in cells treated with blocking antibodies against integrin ␣ V

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