Beca Fogarty
Translational Informatics for
Global Health
Ejes del Desarrollo de conocimiento del NIH
● Categorías de la Investigación Clínica del NIH:
– Investigación orientada a pacientes
– Investigación Epidemiológica y del comportamiento
● NIH Roadmap for Medical Research
– Launched in September, 2004
– Speed scientific discovery and its efficient translation to patient care
– Transform the way biomedical research is conducted by overcoming specific hurdles or filling defined
knowledge gaps.
– 12 challenges have been categorized according to three themes:
•
New Pathways to Discovery•
Research Teams of the Future•
Reengineering the Clinical Research EnterpriseNew Pathways to Discovery
● Building Blocks, Pathways, and Networks Implementation Group – National Technology Centers for Networks and Pathways.
– Metabolomics Technology Development.
– Standards for Proteomics and Metabolomics/Assessment of Critical Reagents for Proteomics.
● Molecular Libraries and Imaging Implementation Group
– Molecular Libraries Screening Center Network (MLSCN).
– Cheminformatics
– Technology Development.
– Development of High Specificity/High Sensitivity Probes to Improve Detection.
– Comprehensive Trans-NIH Imaging Probe Database.
– Core Synthesis Facility to Produce Imaging Probes.
● Structural Biology Implementation Group – Protein Production Facilities.
● Bioinformatics and Computational Biology Implementation Group – National Centers for Biomedical Computing.
● Nanomedicine Implementation Group
Research Teams of the Future
●
Interdisciplinary Research Implementation
Group
– Interdisciplinary Research Centers
– Interdisciplinary Research Training Initiative
– Interdisciplinary Research in The Behavioral and Social Sciences
– Removing Structural Barriers to Interdisciplinary Research
Reengineering the Clinical Research Enterprise
● Initiatives:
– Clinical Research Networks and NECTAR (National Electronic Clinical Trials and Research) ej. REDcap
– Clinical Outcomes Assessment
– Clinical Research Training
•
Multidisciplinary Research Career Development Program:–
patient oriented research–
translational research–
small and large scale clinical investigation and trials–
epidemiologic and natural history studies– Clinical Research Policy Analysis and Coordination
Research electronic data capture (REDCap) Vanderbilt University
● Critical components for supporting research projects:
– collaborative access to data across academic departments and institutions; – user authentication and role-based security
– intuitive electronic case report forms (CRFs)
– real-time data validation, integrity checks and other mechanisms for ensuring data quality (e.g. double-data entry options)
– data attribution and audit capabilities – protocol document storage and sharing – central data storage and backups
– data export functions for common statistical packages
– data import functions to facilitate bulk import of data from other systems. – a software generation cycle sufficiently fast to accommodate multiple
concurrent projects without the need for custom project-specific programming
– a model capable of meeting disparate data collection needs of projects across a wide array of scientific disciplines.
Clinical and Translational Science Awards (CTSA)
● Launched in 2006, it now includes 46 medical research institutions in 26 states.
● The program’s goals are:
– Eliminate growing barriers between clinical and basic research, to address the increasing complexities
involved in conducting clinical research
– Help institutions nationwide create an academic home for clinical and translational science.
Definiciones
● CRI – Clinical Research Informatics– subdomain of Biomedical Informatics concerned
with the development, application, and evaluation of theories, methods, and systems to optimize the
design and conduct of clinical research and the analysis, interpretation, and dissemination of the information generated.
● TRI – Translational Research Informatics
– subdomain of Biomedical Informatics concerned
with the development, application, and evaluation of theories, methods, and systems to facilitate the
translation basic science discoveries into practicable therapies
Fogarty International Center, NIH
● Fogarty International Center
– Dedicated to advancing the mission of the NIH by supporting and facilitating global health research conducted by U.S. and international investigators
– Build partnerships between health research
institutions in the U.S. and abroad, and training the next generation of scientists to address global health needs.
– Becas con financiacion del NIH para capacitacion en IM para el desarrollo de la salud global.
Fogarty International Center, NIH
● Programa ITGH (Informatics Training for Global Health)
– Principal objetivo: capacitar investigadores en el desarrollo y utilización de sistemas de información en paises no desarrollados
ITGH: Build Capacity in Informatics in Global Health
● U$S 9.23 millones para 8 propuestas – OHSU y Hospital Italiano
– Universidad de Pittsburgh y Universidad Javeriana en Colombia (formación en IM para investigación clínica)
– Universidad Cayetano Heredia en Perú y junto con Colombia y Ecuador y la
Universidad de Washington (creación de la Andean Global Health Informatics Research and Training Center)
– Universidad de Georgia y Fundación Oswaldo Cruz de Brasil (bioinformática para enfermedades tropicales)
– Universidad de California en San Diego y Universidad de Sao Paulo (capacitación de investigadores en Mozambique)
– Universidad de Vanderbilt y la India (HIV)
– Universidad de KwaZulu-Natal en Sudáfrica (capacitación pan-africana con instituciones de Mozambique, Uganda y Zimbabwe)
– Universidad de Indiana y Universidad de Moi en Kenya (desarrollo de East African Center of Excellence in Health Informatics)
Translational Informatics for Global Health.
HIBA-OHSU.
● Objetivos
– Ampliar la colaboración existente en IM con el objetivo principal de ampliar la capacidad de investigación clínica HIBA en las
enfermedades cardiovasculares crónicas a través de clinical translational research informatics (CTRI)
– Brindar capacitación para investigadores clínicos y su personal en informática biomédica (Clinical Research informatics).
– Proporcionar formación a largo plazo para los futuros líderes en el ámbito académico de informática biomédica en OHSU.
– Establecer HIBA como centro de excelencia internacional en informática médica.
– Desarrollar una maestría en informática biomédica entre HIBA y OHSU.
Cursos Previstos
● 10x10 OHSU
– Clinical Research Informatics
● Translational Research Informatics
Trabajos Previstos
● Clinical Trial en enfermedades crónicas que evalúe el impacto en outcomes de la implementación de
herramientas informáticas que favorezcan la traslación del conocimiento al punto de asistencia (traslational science)
Capacidades locales para la sustentabilidad
● 4 fellows con MSc degree
● Maestria de IM propia en colaboración con OHSU y
Resultados
● Mejora de la habilidad y la capacidad para llevar a cabo CTRI en HIBA con el fin de mejorar la gestión de
enfermedades crónicas.
● Mejora de la actividad y planes de estudio en CTRI en HIBA
● Brindar nuevas oportunidades de investigación basadas en IM para la investigación clínica en América Latina.
