Scientific Report 2014

Scientific Report

2014

INDEX

EXECUTIVE SUMMARY I-VII

1. ^{CENTER 3}

a. New Groups 3

b. Area Distribution 3

c. Networks 4

2. SCIENTIFIC PRODUCTION 7

a. Papers 7

b. Books And Book Chapters 33

c. Patents 35

3. FINANCIAL RESOURCES 37

a. 2014 New Funding 37

b. 2014 Active 47

4. HUMAN RESOURCES 63

a. New 63

b. Stays 65

5. EDUCATION 71

a. Thesis 71

b. Conferences 72

c. Congress 75

6. ACTIVITY 77

Executive Summary

I

EXECUTIVE SUMMARY

1.

SCIENTIFIC ACTIVITY

a.

Human resources and talent recruiment:

Currently more than 200 people work at CiMUS in different positions: PIs, postdocs, predocs, technicians...

The principal highlights in 2014 in this area were:



New Group Leaders:



Rubén Nogueiras-Molecular Metabolism group: Associate professor of Physiology. He has a starting grants projects from ERC. He was already at CiMUS with a Ramon y Cajal in the Functional Obesomics & Molecular Metabolism group .



Miguel González Blanco- DNA Repair and Genome Integrity: He has a a contract from the Ramon y Cajal Program, which obtained after postdoctoral stay at Clare Hall Laboratories, London Research Institute, Cancer Research UK (London).



Postdocs: 4 people were incorporated as postdoctoral fellows. Eva Tuduri joined the Molecular Metabolism group with a Sara Borrell Contract. José Crecente, Inmaculada Conejos and Daniel Torrecilla are postdoctoral contracts in 2014 as well.



Predocs and master students: They are the biggest part of the CiMUS staff. At present they are more than 100. In 2014, 19 new predocs started their thesis project at CiMUS. Some of the predocs come from other contries like Italy, Portugal, Swaziland, Egipt, France, India, Azerbaijan, Bangladesh, Turkmenistan, Pakistan, Hungary and Serbia.

b.

Financial resources:



International Projects: The principal source was, like previous years the EU competitive programs. In 2014 the 57, 5% of the budget comes from these programs. There are several projects, which main origin are the Frame Program:



PRIORITY- Jesús R. Requena



NEUROFAST- Carlos Diéguez



OPENPHACTS (Innovative Medicine Initiatives)-Mabel Loza

II



ObERStress (Consolidated Grant)-Miguel López



Malformaciones cerebrales cavernosas. De la patobiología a estrategias terapéuticas- Juan Zalvide



DRUGS4RARE-Mabel Loza



TRANS-INT- María José Alonso; Carlos Diéguez



NanoFar: María José Alonso



OBESITY53 (Starting Grant): Rubén Nogueiras



EUROFORGEN-NoE: Ángel Carracedo



HELIX: Ángel Carracedo



FaBiMed: José Ramón González Juanatey

Special mention to the Innopharma program, a collaborative project with the leadership of two CiMUS PIs: Mabel Loza and Ángel Carracedo, with a whole budget of 10 Million € and which is under development at the center.



National Projects: In 2014, 7 new projects started at CiMUS, from National agencies. There was a total of 17 active projects.They were the 10,5 % of the economic amount.



Regional Projects: The groups got 8 new projects from the regional government, which joined other 6 that were active at that moment. They represents the 16,4%

of the CiMUS budget.

Special mention to the Biofarma-Esteve Joint Unit funded by Xunta de Galicia and Esteve, and which is a collaborative unit of the Biofarma group and Esteve, one of the principals spanish Pharma. The objective of this unit is the search and development of drugs to treat chronic pain. The total amount was 2,34 M€.



Contracts, agreements and donations: They were the 15% of the budget of the

CiMUS in 2014. For the first time it also includes resources coming from a donation.

III c.

Scientific Production and excellence research:



Scientific publications: In 2014 149 papers were published by the groups. Most of them, 77%, were published at journals that belongs to the Q1, and inside of this quartile, the 37% are at first decile. This reflects the excellence and quality of the wok being developed.

All the papers got an IF accumulated of 815,603, with an IF average of 5,474.

A relevant number, 18%, were collaborations between CiMUS groups, and the 48%

were made with other international groups.

IV



PhD Thesis: 10 Thesis were defended by predocs that develop their work at the center.



Stays: Several researchers from groups of different national and international institutions had stayed at CiMUS, developing projects or collaborations with the groups. A relevant number, 48 people, come from different countries like Portugal, England Romania Turkey Italy, Ecuador, Latvia, Germany, Belgium, Cyprus, Tunisia, Hungary, Colombia, Brazil and Bulgaria.

In the same way, 11 CiMUS researchers travelled to other institutions to develop parts of their projects there. These institutions are countries like Spain, Portugal, Germany, Belgium, Italy, USA, Slovak Republic or United Kingdom



International collaborations:72 of the scientific publications were a collaborative work with international groups, which represents the 48 % of the papers.



Technology transfer



Patents: 2 new applications were presented from CiMUS groups



Spin-Offs: Biostatech, created in 2012, still work from Carmen Cadarso group at the CiMUS

2.

CONFERENCES AND SEMINARS

a.

Congress organization and international workshops:



Congress of the European Thyroid Association, September 6

to 10

of 2014 Santiago de Compostela, Spain. Prof. Clara V. Álvarez was the chair of the organitation commitee



Simposium “Frontiers in Obesity and Metabolism Research:Twentieth anniversary of leptin discovery” November 10

to-12

Novembro de 2014 Miguel López and Rubén Nogueiras, were chairs of this workshop.



Workshop on Rupture Technologies: Viewing molecular events: functional

imaging methods in preclinical models for drug development, November

6th to 7th 2014. Organized by TRANSBIO-SUDOE program

V b.

Seminars:

44 seminars were hold at the CiMUS. There are three different categories in these seminars:



CiMUS Update: This program of conferences started in 2014. The speaker is one of the CiMUS PIs, and talk about their research lines. These were: Jesús R. Requena, Juan Zalvide and Clara V. Álvarez.



Happy Fridays: The recent postdocs and last year predocs presented their work. A total of 12 talks were presented this year.



Seminars: The speakers are national and internationals scientist. There were 29 seminars in 2014.

3.

DISCLOSURE AND COMMUNICATION

Web page and Social Media:



Web page, Facebook profile and Researchgate: We are increasing the contents of CiMUS web page to mantein updated it with the activities of the center (http://www.usc.es/cimus/). We keep our Facebook profile, which had a big rising since the mid year (https://www.facebook.com/CIMUS.USC). The CiMUS Researchgate its an active platform where the number of researcher´s profiles was increased in a 130%, with a 69 active profiles.



Twitter: In the mid-year the CiMUS arrived at twitter: https://twitter.com/cimususc



Linkedin: At the same time of the twitter, we started to run the CiMUS Linkedin profile, a network with a profesional profile orientation.

https://es.linkedin.com/company/cimus



Youtube chanel: This chanel was creating to be a multimedia tool to present the groups of the center with video. The first was from Innopharma poject and it had a big reception, with almost 300 views. https://www.youtube.com/user/cimususc

b.

Join BIOSPAIN forum: CIMUS was present in this forum celebrated in Santiago de Compostela on 24th to 26th of September. The center was represented in the stands of Innopharma, IDIS and in the one shared by Campus Vida and Campus do Mar.

c.

CiMUS presentation to schools: Students from some high schools, IES Sanchez Cantón

and IES Cacheiras, visited the center to know the CiMUS labs and platforms.

VI

d.

CiMUS presentation to the Financial sector: A group of bussinesmen from a Venture

capital fund visited the center to known the infrastructure and the groups that works

there.

Scientific Report 2014

3

1. CENTER

a. NEW GROUPS

In 2014, 2 new groups were incorporated at CiMUS:

 Metabolic Metabolism: PI Rubén Nogueiras-Endocrinology and Nutrition Area.

 DNA Repair and Genome Integrity: PI Miguel González Blanco- Cancer Area

b. AREAS

Currentlly the structure of the diferent areas is:

CANCER

Anxo Vidal

Clara V.

Álvarez Román Pérez- Fernández

Jose Antonio Costoya Celia Mª Pombo Carmen Rivas Miguel González

Blanco

ENDOCRIN OLOGY

AND NUTRITION

Carlos Diéguez

Miguel López

Rubén Nogueiras

Rosa Señarís

María García

Joaquin Lado

NEUROSCIE NCE

Francisco González Antonio Canedo José Luis Labandeir

a Marián

Castro Mª Josefa

Guerra Jannette Rodríguez

Jesús R.

Requena

CARDIOVA SCULAR

José Ramón González-

Juanatey

Juan Zalvide

Dolores Viña

DRUGS AND EXPERIME

NTAL THERAPIES

Mabel Loza

Mª José Alonso

GENETICS AND FUNTIONA L GENOMIC

Ángel Carracedo

Fernando Domíngue

z

BIOSTATIS TICS PLATAFOR

M

Carmen Cadarso

4

c. NETWORKS

4 Groups from CiMUS are leading 4 autonomic networks:

 REGID: Rede Galega de Investigación e Desenvolvemento de Medicamentos-IP

coordinator: Mabel Loza

 REDICENT: Red de investigación en células madre y terapia celular- IP

coordinator: Clara V. Álvarez

 RATGA: Rede de Animais Transxénicos de Galicia- IP coordinator: Jose Antonio

Costoya

 INBIOEST: Novas ferramentas estatíticas e computacionais aplicadas á

investigación en Saúde, Deporte e Medio Ambiente.-IP coordinator: Carmen Cadarso

Also, the CiMUS groups joins another national and international networks:

 National:

 CIBERs:

 CiberObn: Carlos Diéguez, Miguel López; Rubén Nogueiras http://www.ciberobn.es/

 CiberER: Ángel Carracedo http://www.ciberer.es/index.php

 CiberNED: Jose Luis Labandeira-García http://www.ciberned.es/

 Ciberbbn: María José Alonso http://www.ciber-bbn.es/es

 RETICs



TERCEL : José Luis Labandeira-García: http://www.red-tercel.com/

5



RECAVA: Angel Carracedo e Jose Ramón González-Juanatey



REDINSCOR : Jose Ramón González-Juanatey

http://www.eulate.net/redinscor2/



COMBIOMED : MªIsabel Loza http://combiomed.isciii.es/

 Other networks:

 Consolider‐Nanobiomed: Maria José Alonso

http://ina.unizar.es/consolider/

 BIOSTATNET (Biostatistics National Network): Carmen Cadarso http://eio.usc.es/pub/biostatnet/

 Math‐in (Math-Industry Spanish Network): Carmen Cadarso http://www.math-in.net/

 Galician Obesity Network: Carlos Diéguez

 International:

 EUROFORGEN-NoE (European Forensic Genetics Network of

Excelellence): Angel Carracedo http://www.euroforgen.eu/

 European Consortium of Lipodistrophies: David Araujo

http://www.european-lipodystrophies.org/

7

2. SCIENTIFIC PRODUCTION a. Papers

2011 2012 2013 2014

Nº 154 195 201 149

IF 694,344 1102,296 1104,623 815,603

IF average 4,509 5,653 5,496 5,474

CiMUS Colab 19 (12,3%) 19 (9,5 %) 23 (11%) 27 (18,1%) Intern Colab 62 (40,3%) 75 (38,46%) 67 (33%) 72(48,32 %)

37%

40%

16%

3% 4%

Publications 2014

D1 Q1 no D1 Q2 Q3 Q4

0%

20%

40%

60%

80%

100%

2011 2012 2013 2014

% Publications per quartile

Q4 Q3 Q2 Q1 no D1 Q1D1

0%

20%

40%

60%

80%

2011 2012 2013 2014

% Publications per quartile

No Q1 Q1

8

Nº Publications:

0 50 100 150

2011 2012

2013 2014

Nº Publications

No Q1 Q1

0 50 100 150 200 250

2011 2012 2013 2014

Nº Publications

No Q1 Q1

0 50 100 150 200 250

2011 2012 2013 2014

Nº Publications

No Q1 Q1 no D1 Q1D1 0%

20%

40%

60%

80%

100%

2011 2012 2013 2014

% Publications per quartile

No Q1 Q1

0%

20%

40%

60%

80%

100%

2011 2012 2013 2014

% Publications per quartile

No Q1 Q1 no D1 Q1D1

9

IF Average

0 5 10 15

2011 2012 2013

2014

IF Average

No Q1 Q1 no D1 0 Q1D1

2 4 6 8

2011 2012

2013 2014

IF Average

No Q1 Q1

11

Title Authors Journal Publication IF Q D1

Synaptic, transcriptional and chromatin genes disrupted in autism.

De Rubeis S, He X, Goldberg AP, Poultney CS, Samocha K, Cicek AE, Kou Y, Liu L, Fromer M, Walker S, Singh T, Klei L, Kosmicki J, Shih-Chen F, Aleksic B, Biscaldi M, Bolton PF, Brownfeld JM, Cai J, Campbell NG, Carracedo A, Chahrour MH, Chiocchetti AG, Coon H, Crawford EL, Curran SR, Dawson G, Duketis E,

Fernandez BA, Gallagher L, Geller E, Guter SJ, Hill RS, Ionita-Laza J, Jimenz Gonzalez P, Kilpinen H, Klauck SM, Kolevzon A, Lee I, Lei I, Lei J, Lehtimäki T, Lin CF, Ma’ayan A, Marshall CR, McInnes AL, Neale B, Owen MJ, Ozaki N, Parellada M, Parr JR, Purcell S, Puura K, Rajagopalan D, Rehnström K, Reichenberg A, Sabo A, Sachse M, Sanders SJ, Schafer C, Schulte-Rüther M, Skuse D, Stevens C, Szatmari P, Tammimies K, Valladares O, Voran A, Li- San W, Weiss LA, Willsey AJ, Yu TW, Yuen RK; DDD Study;

Homozygosity Mapping Collaborative for Autism; UK10K Consortium, Cook EH, Freitag CM, Gill M, Hultman CM, Lehner T, Palotie A, Schellenberg GD, Sklar P, State MW, Sutcliffe JS, Walsh CA, Scherer SW, Zwick ME,Barett JC, Cutler DJ, Roeder K, Devlin B, Daly MJ, Buxbaum JD.

Nature. 2014 Nov 13;515(7526):209 -15.

42,351 1 1

Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1

retrotransposition in cancer genomes.

Tubio JM, Li Y, Ju YS, Martincorena I, Cooke SL, Tojo M, Gundem G, Pipinikas CP, Zamora J, Raine K, Menzies A, Roman-Garcia P, Fullam A, Gerstung M, Shlien A, Tarpey PS, Papaemmanuil E, Knappskog S, Van Loo P, Ramakrishna M, Davies HR, Marshall J, Wedge DC, Teague JW, Butler AP, Nik-Zainal S, Alexandrov L, Behjati S, Yates LR, Bolli N, Mudie L, Hardy C, Martin S, McLaren S, O’Meara S, Anderson E, Maddison M, Gamble S; ICGC Breast Cancer Group; ICGC Bone Cancer Group; ICGC Prostate Cancer Group, Foster C, Warren AY, Whitaker H, Brewer D, Eeles R, Cooper C, Neal D, Lynch AG, Visakorpi T, Isaacs WB, van’t Veer L, Caldas C, Desmedt C, Sotiriou C, Aparicio S, Foekens JA, Eyfjörd JE, Lakhani SR, Thomas G, Myklebost O, Span PN, Børresen-Dale AL, Richardson AL, Van de Vijver M, Vincent- Salomon A, Van den Eynden GG, Flanagan AM, Futreal PA, Janes

Science. 2014 Aug 1;345(6196):1251 343.

31,477 1 1

12

Title Authors Journal Publication IF Q D1

SM, Bova GS, Stratton MR, McDermott U, Campbell PJ A three-stage genome-wide association study

identifies a susceptibility locus for late radiotherapy toxicity at 2q24.1.

Fachal L, Gómez-Caamaño A, Barnett GC, Peleteiro P, Carballo AM, Calvo-Crespo P, Kerns SL, Sánchez-García M, Lobato-Busto R, Dorling L, Elliott RM, Dearnaley DP, Sydes MR, Hall E, Burnet NG, Carracedo Á, Rosenstein BS, West CM, Dunning AM, Vega A.

Nat Genet. 2014

Aug;46(8):891-4.

29,648 1 1

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.

Arking DE, Pulit SL, Crotti L, van der Harst P, Munroe PB, Koopmann TT, Sotoodehnia N, Rossin EJ, Morley M, Wang X, Johnson AD, Lundby A, Gudbjartsson DF, Noseworthy PA, Eijgelsheim M, Bradford Y, Tarasov KV, Dörr M, Müller-Nurasyid M, Lahtinen AM, Nolte IM, Smith AV, Bis JC, Isaacs A, Newhouse SJ, Evans DS, Post WS, Waggott D, Lyytikäinen LP, Hicks AA, Eisele L, Ellinghaus D, Hayward C, Navarro P, Ulivi S, Tanaka T, Tester DJ, Chatel S, Gustafsson S, Kumari M, Morris RW, Naluai ÅT, Padmanabhan S, Kluttig A, Strohmer B, Panayiotou AG, Torres M, Knoflach M, Hubacek JA, Slowikowski K,

Raychaudhuri S, Kumar RD, Harris TB, Launer LJ, Shuldiner AR, Alonso A, Bader JS, Ehret G, Huang H, Kao WH, Strait JB, Macfarlane PW, Brown M, Caulfield MJ, Samani NJ, Kronenberg F, Willeit J; CARe Consortium; COGENT Consortium, Smith JG, Greiser KH, Meyer Zu Schwabedissen H, Werdan K, Carella M, Zelante L, Heckbert SR, Psaty BM, Rotter JI, Kolcic I, Polašek O, Wright AF, Griffin M, Daly MJ; DCCT/EDIC, Arnar DO, Hólm H, Thorsteinsdottir U; eMERGE Consortium, Denny JC, Roden DM, Zuvich RL, Emilsson V, Plump AS, Larson MG, O’Donnell CJ, Yin X, Bobbo M, D’Adamo AP, Iorio A, Sinagra G, Carracedo A, Cummings SR, Nalls MA, Jula A, Kontula KK, Marjamaa A, Oikarinen L, Perola M, Porthan K, Erbel R, Hoffmann P, Jöckel KH, Kälsch H, Nöthen MM; HRGEN Consortium, den Hoed M, Loos RJ, Thelle DS, Gieger C, Meitinger T, Perz S, Peters A, Prucha H, Sinner MF, Waldenberger M, de Boer RA, Franke L,

Nat Genet. 2014

Aug;46(8):826- 36.

29,648 1 1

13

Title Authors Journal Publication IF Q D1

van der Vleuten PA, Beckmann BM, Martens E, Bardai A, Hofman N, Wilde AA, Behr ER, Dalageorgou C, Giudicessi JR, Medeiros-Domingo A, Barc J, Kyndt F, Probst V, Ghidoni A, Insolia R, Hamilton RM, Scherer SW, Brandimarto J, Margulies K, Moravec CE, del Greco M F, Fuchsberger C, O’Connell JR, Lee WK, Watt GC, Campbell H, Wild SH, El Mokhtari NE, Frey N, Asselbergs FW, Mateo Leach I, Navis G, van den Berg MP, van Veldhuisen DJ, Kellis M, Krijthe BP, Franco OH, Hofman A, Kors JA, Uitterlinden AG, Witteman JC, Kedenko L, Lamina C, Oostra BA, Abecasis GR, Lakatta EG, Mulas A, Orrú M, Schlessinger D, Uda M, Markus MR, Völker U, Snieder H, Spector TD, Ärnlöv J, Lind L, Sundström J, Syvänen AC, Kivimaki M, Kähönen M, Mononen N, Raitakari OT, Viikari JS, Adamkova V, Kiechl S, Brion M, Nicolaides AN, Paulweber B, Haerting J, Dominiczak AF, Nyberg F, Whincup PH, Hingorani AD, Schott JJ, Bezzina CR, Ingelsson E, Ferrucci L, Gasparini P, Wilson JF, Rudan I, Franke A, Mühleisen TW, Pramstaller PP, Lehtimäki TJ, Paterson AD, Parsa A, Liu Y, van Duijn CM, Siscovick DS, Gudnason V, Jamshidi Y, Salomaa V, Felix SB, Sanna S, Ritchie MD, Stricker BH,

Stefansson K, Boyer LA, Cappola TP, Olsen JV, Lage K, Schwartz PJ, Kääb S, Chakravarti A, Ackerman MJ, Pfeufer A, de Bakker PI, Newton-Cheh C.

Estradiol regulates brown adipose tissue thermogenesis via hypothalamic AMPK.

Martínez de Morentin PB, González-García I, Martins L, Lage R, Fernández-Mallo D, Martínez-Sánchez N, Ruíz-Pino F, Liu J, Morgan DA, Pinilla L, Gallego R, Saha AK, Kalsbeek A, Fliers E, Bisschop PH, Diéguez C, Nogueiras R, Rahmouni K, Tena- Sempere M, López M.

Cell Metab.

2014 Jul 1;20(1):41-53.

16,747 1 1

Common variant at 16p11.2 conferring risk of psychosis.

Steinberg S, de Jong S, Mattheisen M, Costas J, Demontis D, Jamain S, Pietiläinen OP, Lin K, Papiol S, Huttenlocher J, Sigurdsson E, Vassos E, Giegling I, Breuer R, Fraser G, Walker N, Melle I, Djurovic S, Agartz I, Tuulio-Henriksson A, Suvisaari J, Lönnqvist J, Paunio T, Olsen L, Hansen T, Ingason A, Pirinen M,

Mol Psychiatry.

2014

Jan;19(1):108-14.

15,147 1 1

14

Title Authors Journal Publication IF Q D1

Strengman E; GROUP, Hougaard DM, Orntoft T, Didriksen M, Hollegaard MV, Nordentoft M, Abramova L, Kaleda V, Arrojo M, Sanjuán J, Arango C, Etain B, Bellivier F, Méary A, Schürhoff F, Szoke A, Ribolsi M, Magni V, Siracusano A, Sperling S, Rossner M, Christiansen C, Kiemeney LA, Franke B, van den Berg LH, Veldink J, Curran S, Bolton P, Poot M, Staal W, Rehnstrom K, Kilpinen H, Freitag CM, Meyer J, Magnusson P, Saemundsen E, Martsenkovsky I, Bikshaieva I, Martsenkovska I, Vashchenko O, Raleva M, Paketchieva K, Stefanovski B, Durmishi N, Pejovic Milovancevic M, Lecic Tosevski D, Silagadze T, Naneishvili N, Mikeladze N, Surguladze S, Vincent JB, Farmer A, Mitchell PB, Wright A, Schofield PR, Fullerton JM, Montgomery GW, Martin NG, Rubino IA, van Winkel R, Kenis G, De Hert M, Réthelyi JM, Bitter I, Terenius L, Jönsson EG, Bakker S, van Os J, Jablensky A, Leboyer M, Bramon E, Powell J, Murray R, Corvin A, Gill M, Morris D, O’Neill FA, Kendler K, Riley B; Wellcome Trust Case Control Consortium 2, Craddock N, Owen MJ, O’Donovan MC, Thorsteinsdottir U, Kong A, Ehrenreich H, Carracedo A, Golimbet V, Andreassen OA, Børglum AD, Mors O, Mortensen PB, Werge T, Ophoff RA, Nöthen MM, Rietschel M, Cichon S, Ruggeri M, Tosato S, Palotie A, St Clair D, Rujescu D, Collier DA, Stefansson H, Stefansson K.

Guidelines on non-cardiac surgery:

cardiovascular assessment and management:

The Joint Task Force on non-cardiac surgery:

cardiovascular assessment and management of the European Society of Cardiology (ESC) and the European Society of Anaesthesiology (ESA).

Kristensen SD, Knuuti J, Saraste A, Anker S, Bøtker HE, Hert SD, Ford I, Gonzalez-Juanatey JR, Gorenek B, Heyndrickx GR, Hoeft A, Huber K, Iung B, Kjeldsen KP, Longrois D, Lüscher TF, Pierard L, Pocock S, Price S, Roffi M, Sirnes PA, Sousa-Uva M, Voudris V, Funck-Brentano C; Authors/Task Force Members. 2014 ESC/ESA

Eur Heart J.

2014 Sep 14;35(35):2383- 431.

14,723 1 1

Dual control of Yen1 nuclease activity and cellular localization by Cdk and Cdc14 prevents genome instability.

Blanco MG, Matos J, West SC. Mol Cell. 2014 Apr

10;54(1):94-106.

14,464 1 1

15

Title Authors Journal Publication IF Q D1

Fluorescent drug-loaded, polymeric-based, branched gold nanoshells for localized multimodal therapy and imaging of tumoral cells.

Topete A, Alatorre-Meda M, Iglesias P, Villar-Alvarez EM, Barbosa S, Costoya JA, Taboada P, Mosquera V.

ACS Nano. 2014 Mar 25;8(3):2725-38.

12,033 1 1

HLA-DRB1*15:01 allele protects from asthma susceptibility.

Pino-Yanes M, Corrales A, Acosta-Herrera M, Pérez-Rodríguez E, Cumplido J, Campo P, Barreto-Luis A, Sánchez-García F, Felipe T, Sánchez-Machín I, Quintela I, García-Robaina JC, Villar J, Blanca M, Carracedo A, Carrillo T, Flores C.

J Allergy Clin Immunol.

2014

Nov;134(5):1201- 3.

11,248 1 1

TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins.

Meseguer V, Alpizar YA, Luis E, Tajada S, Denlinger B, Fajardo O, Manenschijn JA, Fernández-Peña C, Talavera A, Kichko T, Navia B, Sánchez A, Señarís R, Reeh P, Pérez-García MT, López-López JR, Voets T, Belmonte C, Talavera K, Viana F.

Nat Commun.

2014;5:3125. 10,742 1 1

Genome analysis of a major urban malaria vector mosquito, Anopheles stephensi.

Jiang X, Peery A, Hall A, Sharma A, Chen XG, Waterhouse RM, Komissarov A, Riehl MM, Shouche Y, Sharakhova MV, Lawson D, Pakpour N, Arensburger P, Davidson VL, Eiglmeier K, Emrich S, George P, Kennedy RC, Mane SP, Maslen G, Oringanje C, Qi Y, Settlage R, Tojo M, Tubio JM, Unger MF, Wang B, Vernick KD, Ribeiro JM, James AA, Michel K, Riehle MA, Luckhart S, Sharakhov IV, Tu Z.

Genome Biol.

2014 Sep 23;15(9):459

10,465 1 1

Eating addiction, rather than “food addiction”, better captures addictive-like eating behavior.

Hebebrand J, Albayrak Ö, Adan R, Antel J, Dieguez C, de Jong J, Leng G, Menzies J, Mercer JG, Murphy M, van der Plasse G, Dickson SL.

Neurosci Biobehav Rev.

2014 Sep 6;47C:295-306.

10,284 1 1

Identifying gene-environment interactions in schizophrenia: contemporary challenges for integrated, large-scale investigations.

European Network of National Networks studying Gene- Environment Interactions in Schizophrenia (EU-GEI), van Os J, Rutten BP, Myin-Germeys I, Delespaul P, Viechtbauer W, van Zelst C, Bruggeman R, Reininghaus U, Morgan C, Murray RM, Di Forti M, McGuire P, Valmaggia LR, Kempton MJ, Gayer-

Anderson C, Hubbard K, Beards S, Stilo SA, Onyejiaka A, Bourque F, Modinos G, Tognin S, Calem M, O’Donovan MC, Owen MJ, Holmans P, Williams N, Craddock N, Richards A, Humphreys I, Meyer-Lindenberg A, Leweke FM, Tost H, Akdeniz

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Messchaert E, Kraan T, Burger N, Leboyer M, Szoke A, Schürhoff F, Llorca PM, Jamain S, Tortelli A, Frijda F, Vilain J, Galliot AM, Baudin G, Ferchiou A, Richard JR, Bulzacka E, Charpeaud T, Tronche AM, De Hert M, van Winkel R, Decoster J, Derom C, Thiery E, Stefanis NC, Sachs G, Aschauer H, Lasser I, Winklbaur B, Schlögelhofer M, Riecher-Rössler A, Borgwardt S, Walter A, Harrisberger F, Smieskova R, Rapp C, Ittig S, Soguel-dit-Piquard F, Studerus E, Klosterkötter J, Ruhrmann S, Paruch J, Julkowski D, Hilboll D, Sham PC, Cherny SS, Chen EY, Campbell DD, Li M, Romeo-Casabona CM, Emaldi Cirión A, Urruela Mora A, Jones P, Kirkbride J, Cannon M, Rujescu D, Tarricone I, Berardi D, Bonora E, Seri M, Marcacci T, Chiri L, Chierzi F, Storbini V, Braca M, Minenna MG, Donegani I, Fioritti A, La Barbera D, La Cascia CE, Mulè A, Sideli L, Sartorio R, Ferraro L, Tripoli G, Seminerio F, Marinaro AM, McGorry P, Nelson B, Amminger GP, Pantelis C, Menezes PR, Del-Ben CM, Gallo Tenan SH, Shuhama R, Ruggeri M, Tosato S, Lasalvia A, Bonetto C, Ira E, Nordentoft M, Krebs MO, Barrantes-Vidal N, Cristóbal P, Kwapil TR, Brietzke E, Bressan RA, Gadelha A, Maric NP, Andric S, Mihaljevic M, Mirjanic T.

GLP-1: the oracle for gastric bypass? Frühbeck G, Nogueiras R. Diabetes. 2014

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Moreno-Navarrete JM, Novelle MG, Catalán V, Ortega F, Moreno M, Gomez-Ambrosi J, Xifra G, Serrano M, Guerra E, Ricart W, Frühbeck G, Diéguez C, Fernández-Real JM.

Diabetes Care.

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Kaposi’s sarcoma-associated herpesvirus lana2 protein interacts with the pocket proteins and inhibits their sumoylation.

Marcos-Villar L, Gallego P, Muñoz-Fontela C, de la Cruz-Herrera CF, Campagna M, González D, Lopitz-Otsoa F, Rodríguez MS, Rivas C.

Oncogene. 2014 Jan

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GLP-1 agonism stimulates brown adipose tissue thermogenesis and browning through hypothalamic AMPK.

Beiroa D, Imbernon M, Gallego R, Senra A, Herranz D, Villarroya F, Serrano M, Fernø J, Salvador J, Escalada J, Dieguez C, Lopez M, Frühbeck G, Nogueiras R.

Diabetes. 2014

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Implantable controlled release devices for BMP-7 delivery and suppression of glioblastoma initiating cells

Reguera-Nunez, E ; Roca, C; Hardy, E; de la Fuente, M; Csaba, N; Garcia-Fuentes, M

BIOMATER IALS

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2859-67

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Cuba: exploring the history of admixture and the genetic basis of pigmentation using autosomal and uniparental markers.

Marcheco-Teruel B, Parra EJ, Fuentes-Smith E, Salas A,

Buttenschøn HN, Demontis D, Torres-Español M, Marín-Padrón LC, Gómez-Cabezas EJ, Alvarez-Iglesias V, Mosquera-Miguel A, Martínez-Fuentes A, Carracedo A, Børglum AD, Mors O.

PLoS Genet.

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Peppas N.A. Duncan R.,.Wnek G.E., Hoffman A.S., Gao G.H., Kim S.,Lee D.S., Hadjiargyrou M., Touitou E., Ainbinder D., Mumper R., Rolland A., Niidome T., Labhasetwar V., Liu S., Zhou G., Huang Y., Xie Z., Jing X., Csaba N., Alonso M.J., Ali O., Mooney D.J., Lönn P., Dowdy S.F., Feng S., Gao J, Lee E.S., Na K., Bae Y.H., Zentner G.M., Kim H., Yoo H.S., Nakayama M., Okano T., Liao Z., Chuang E., Hsiao C., Sung H., Cabral H., Kataoka K., Nair P.R., Discher D., Mitragotri S.,

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Central ceramide-induced hypothalamic lipotoxicity and ER stress regulate energy balance.

Contreras C, González-García I, Martínez-Sánchez N, Seoane- Collazo P, Jacas J, Morgan DA, Serra D, Gallego R, Gonzalez F, Casals N, Nogueiras R, Rahmouni K, Diéguez C, López M.

Cell Rep. 2014 Oct 9;9(1):366-77.

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The human early-life exposome (HELIX):

project rationale and design

Vrijheid M, Slama R, Robinson O, Chatzi L, Coen M, van den Hazel P, Thomsen C, Wright J, Athersuch TJ, Avellana N, Basagaña X, Brochot C, Bucchini L, Bustamante M, Carracedo A, Casas M, Estivill X, Fairley L, van Gent D, Gonzalez JR, Granum B, Gražulevičienė R, Gutzkow KB, Julvez J, Keun HC, Kogevinas M, McEachan RR, Meltzer HM, Sabidó E, Schwarze PE, Siroux V, Sunyer J, Want EJ, Zeman F, Nieuwenhuijsen MJ.

Environ Health Perspect.

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Structure-based discovery of selective serotonin 5-HT(1B) receptor ligands.

Rodríguez D, Brea J, Loza MI, Carlsson J. Structure. 2014 Aug 5;22(8):1140-51.

6,794 1 No

Neuropeptide precursor VGF is genetically associated with social anhedonia and

underrepresented in the brain of major mental illness: its downregulation by DISC1.

Ramos A, Rodríguez-Seoane C, Rosa I, Trossbach SV, Ortega- Alonso A, Tomppo L, Ekelund J, Veijola J, Järvelin MR, Alonso J, Veiga S, Sawa A, Hennah W, García A, Korth C, Requena JR.

Hum Mol Genet.

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Potential therapeutic effect of the secretome from human uterine cervical stem cells against both cancer and stromal cells compared with adipose tissue stem cells.

Eiró N, Sendon-Lago J, Seoane S, Bermúdez MA, Lamelas ML, Garcia-Caballero T, Schneider J, Perez-Fernandez R, Vizoso FJ.

Oncotarge t.

2014 Nov 15;5(21):10692- 708.

6,627 1 1

A unified nomenclature and amino acid numbering for human PTEN.

Pulido R, Baker SJ, Barata JT, Carracedo A, Cid VJ, Chin-Sang ID, Davé V, den Hertog J, Devreotes P, Eickholt BJ, Eng C, Furnari FB, Georgescu MM, Gericke A, Hopkins B, Jiang X, Lee SR, Lösche M, Malaney P, Matias-Guiu X, Molina M, Pandolfi PP, Parsons R, Pinton P, Rivas C, Rocha RM, Rodríguez MS, Ross AH, Serrano M, Stambolic V, Stiles B, Suzuki A, Tan SS, Tonks NK, Trotman LC, Wolff N, Woscholski R, Wu H, Leslie NR.

Sci Signal. 2014 Jul 1;7(332):pe15.

6,337 1 No

Irisin levels during pregnancy and changes associated with the development of preeclampsia.

Garcés MF, Peralta JJ, Ruiz-Linares CE, Lozano AR, Poveda NE, Torres-Sierra AL, Eslava-Schmalbach JH, Alzate JP, Sánchez AY, Sanchez E, Angel-Müller E, Ruíz-Parra AI, Diéguez C, Nogueiras

J Clin Endocrinol Metab.

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Comparative evaluation of HAS-BLED and ATRIA scores by investigating the full potential of their bleeding prediction schemes in non- valvular atrial fibrillation patients on vitamin-K antagonists.

Abumuaileq RR, Abu-Assi E, Raposeiras-Roubin S, López-López A, Redondo-Diéguez A, Álvarez-Iglesias D, Rodríguez-Mañero M, Peña-Gil C, González-Juanatey JR.

Int J Cardiol.

2014 Oct 20;176(3):1259- 61.

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Contrast-induced nephropathy and bleeding: a bidirectional link with prognostic value in acute coronary syndrome.

Raposeiras-Roubín S, Abu-Assi E, Ocaranza-Sánchez R, Barreiro- Pardal C, Bouzas-Cruz N, Castiñeiras-Busto M, López-López A, Pereira-López E, Gestal-Romarí S, Rodríguez-Cordero M, Peña- Gil C, García-Acuña JM, González-Juanatey JR.

Int J Cardiol.

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6,175 1 1

Differential gene expression of C-type

natriuretic peptide and its related molecules in dilated and ischemic cardiomyopathy. A new option for the management of heart failure.

Tarazón E, Roselló-Lletí E, Ortega A, Molina-Navarro MM, Sánchez-Lázaro I, Lago F, González-Juanatey JR, Rivera M, Portolés M.

Int J Cardiol.

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6,175 1 1

Failure of hybrid therapy for the prevention of long-term recurrence of atrial fibrillation.

García Seara J, Raposeiras Roubin S, Gude Sampedro F, Balboa Barreiro V, Martínez Sande JL, Rodríguez Mañero M, González Juanatey JR.

Int J Cardiol.

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6,175 1 1

Involvement of LCA5 in Leber congenital amaurosis and retinitis pigmentosa in the Spanish population.

Corton M, Avila-Fernandez A, Vallespín E, López-Molina MI, Almoguera B, Martín-Garrido E, Tatu SD, Khan MI, Blanco-Kelly F, Riveiro-Alvarez R, Brión M, García-Sandoval B, Cremers FP, Carracedo A, Ayuso C.

Ophthalm ology.

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Jan;121(1):399- 407.

6,17 1 1

Muscle-specific interleukin-6 deletion influences body weight and body fat in a sex- dependent manner.

Ferrer B, Navia B, Giralt M, Comes G, Carrasco J, Molinero A, Quintana A, Señarís RM, Hidalgo J.

Brain Behav Immun.

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Cancer progression by breast tumors with Pit- 1-overexpression is blocked by inhibition of Metalloproteinase (MMP)-13.

Sendon-Lago J, Seoane S, Eiro N, Bermudez MA, Macia M, Garcia-Caballero T, Vizoso FJ, Perez-Fernandez R.

Breast Cancer Res.

2014 Dec 20;16(6):505.

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Highly versatile immunostimulating nanocapsules for specific immune potentiation.

Vicente S, Peleteiro M, Gonzalez-Aramundiz JV, Díaz-Freitas B, Martínez-Pulgarín S, Neissa JI, Escribano JM, Sanchez A, González-Fernández A, Alonso MJ.

Nanomedi cine (Lond).

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Genetic susceptibility, residential radon, and lung cancer in a radon prone area.

Ruano-Ravina A, Pereyra MF, Castro MT, Pérez-Ríos M, Abal- Arca J, Barros-Dios JM.

J Thorac Oncol.

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Aug;9(8):1073- 80.

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Identification of a circulating microvesicle protein network involved in ST-elevation myocardial infarction.

Vélez P, Parguiña AF, Ocaranza-Sánchez R, Grigorian-Shamagian L, Rosa I, Alonso-Orgaz S, de la Cuesta F, Guitián E, Moreu J, Barderas MG, González-Juanatey JR, García Á.

Thromb Haemost.

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A novel stop mutation in the vascular endothelial growth factor-C gene (VEGFC) results in Milroy-like disease.

Balboa-Beltran E, Fernández-Seara MJ, Pérez-Muñuzuri A, Lago R, García-Magán C, Couce ML, Sobrino B, Amigo J, Carracedo A, Barros F.

J Med Genet.

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5,636 1 No

Oleoylethanolamide enhances β-adrenergic- mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat.

Suárez J, Rivera P, Arrabal S, Crespillo A, Serrano A, Baixeras E, Pavón FJ, Cifuentes M, Nogueiras R, Ballesteros J, Dieguez C, Rodríguez de Fonseca F.

Dis Model Mech.

2014

Jan;7(1):129-41.

5,537 1 1

Modulation of cAMP-specific PDE without emetogenic activity: new sulfide-like PDE7 inhibitors.

García AM, Brea J, Morales-García JA, Perez DI, González A, Alonso-Gil S, Gracia-Rubio I, Ros-Simó C, Conde S, Cadavid MI, Loza MI, Perez-Castillo A, Valverde O, Martinez A, Gil C.

J Med Chem.

2014 Oct 23;57(20):8590- 607.

5,48 1 1

The impact of PKR activation: from neurodegeneration to cancer.

Marchal JA, Lopez GJ, Peran M, Comino A, Delgado JR, García- García JA, Conde V, Aranda FM, Rivas C, Esteban M, Garcia MA.

FASEB J. 2014

May;28(5):1965- 74.

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Microglial TNF-α mediates enhancement of dopaminergic degeneration by brain angiotensin.

Borrajo A, Rodriguez-Perez AI, Diaz-Ruiz C, Guerra MJ, Labandeira-Garcia JL.

Glia. 2014

Jan;62(1):145-57.

5,466 1 No

The obesity paradox in heart failure patients with preserved versus reduced ejection fraction: a meta-analysis of individual patient data

Padwal R, McAlister FA, McMurray JJ, Cowie MR, Rich M, Pocock S, Swedberg K, Maggioni A, Gamble G, Ariti C, Earle N, Whalley G, Poppe KK, Doughty RN, Bayes-Genis A; Meta- analysis Global Group in Chronic Heart Failure (MAGGIC)

Int J Obes (Lond)

2014

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Olanzapine depot formulation in rat: a step forward in modelling antipsychotic-induced metabolic adverse effects.

Skrede S, Martins L, Berge RK, Steen VM, López M, Fernø J. Int J Neuropsyc hopharma col.

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FAS system deregulation in T-cell Villa-Morales M, Cobos MA, González-Gugel E, Álvarez-Iglesias Cell Death 2014 Mar 5,177 2 No

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lymphoblastic lymphoma. V, Martínez B, Piris MA, Carracedo A, Benítez J, Fernández- Piqueras J.

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Regulation of NR4A by nutritional status, gender, postnatal development and hormonal deficiency.

Pérez-Sieira S, López M, Nogueiras R, Tovar S. Sci Rep. 2014 Mar 3;4:4264.

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Neonatal events, such as androgenization and postnatal overfeeding, modify the response to ghrelin.

Novelle MG, Vázquez MJ, Martinello KD, Sanchez-Garrido MA, Tena-Sempere M, Diéguez C.

Sci Rep. 2014 May 6;4:4855.

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Translating chitosan to clinical delivery of nucleic acid-based drugs

Pereira Gomes C, Ferreira Lopes C.D, Duarte Moreno P.D., Varela-Moreira A., Alonso M.J., Pêgo A.P

MRS Bull 2014; 39: 60-70 5,069 1 No

Hypothalamic effects of thyroid hormones on metabolism.

Martínez-Sánchez N, Alvarez CV, Fernø J, Nogueiras R, Diéguez C, López M.

Best Pract Res Clin Endocrinol Metab.

2014

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4,907 1 No

Aging-related dysregulation of dopamine and angiotensin receptor interaction.

Villar-Cheda B, Dominguez-Meijide A, Valenzuela R, Granado N, Moratalla R, Labandeira-Garcia JL.

Neurobiol Aging.

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Boukharta L, Gutiérrez-de-Terán H, Aqvist J. Computational prediction of alanine scanning and ligand binding energetics in G-protein coupled receptors.

PLoS Comput Biol. 2014

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Effect of chronic treatment with angiotensin type 1 receptor antagonists on striatal dopamine levels in normal rats and in a rat model of Parkinson’s disease treated with L- DOPA.

Dominguez-Meijide A, Villar-Cheda B, Garrido-Gil P, Sierrra- Paredes G, Guerra MJ, Labandeira-Garcia JL.

Neurophar macology.

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Inhibition of the microglial response is essential for the neuroprotective effects of Rho-kinase inhibitors on MPTP-induced dopaminergic cell death.

Borrajo A, Rodriguez-Perez AI, Villar-Cheda B, Guerra MJ, Labandeira-Garcia JL.

Neurophar macology.

2014 Oct;85:1-8. 4,819 1 1

Lipoprotein internalisation induced by oncogenic AMPK activation is essential to

Ríos M, Foretz M, Viollet B, Prieto A, Fraga M, García-Caballero T, Costoya JA, Señarís R.

Eur J Cancer.

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maintain glioblastoma cell growth. 97.

The brain and brown fat. Contreras C, Gonzalez F, Fernø J, Diéguez C, Rahmouni K, Nogueiras R, López M.

Ann Med. 2014 Jun 10:1-19.

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Nicotine improves obesity and hepatic steatosis and ER stress in diet-induced obese male rats.

Seoane-Collazo P, Martínez de Morentin PB, Fernø J, Diéguez C, Nogueiras R, López M.

Endocrinol ogy.

2014

May;155(5):1679- 89.

4,644 1 No

Somatotropinomas, but not nonfunctioning pituitary adenomas, maintain a functional apoptotic RET/Pit1/ARF/p53 pathway that is blocked by excess GDNF.

Diaz-Rodriguez E, Garcia-Rendueles AR, Ibáñez-Costa A, Gutierrez-Pascual E, Garcia-Lavandeira M, Leal A, Japon MA, Soto A, Venegas E, Tinahones FJ, Garcia-Arnes JA, Benito P, Angeles Galvez M, Jimenez-Reina L, Bernabeu I, Dieguez C, Luque RM, Castaño JP, Alvarez CV.

Endocrinol ogy.

2014

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4,644 1 No

Obesity-induced hypogonadism in the male:

premature reproductive neuroendocrine senescence and contribution of Kiss1-mediated mechanisms.

Sánchez-Garrido MA, Ruiz-Pino F, Manfredi-Lozano M, Leon S, Garcia-Galiano D, Castaño JP, Luque RM, Romero-Ruiz A, Castellano JM, Diéguez C, Pinilla L, Tena-Sempere M.

Endocrinol ogy.

2014

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4,644 1 No

Prolactin and energy homeostasis:

pathophysiological mechanisms and therapeutic considerations.

Tovar S, Diéguez C. Endocrinol

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Natural tetraponerines: a general synthesis and antiproliferative activity.

Bosque I, Gonzalez-Gomez JC, Loza MI, Brea J. J Org Chem.

2014 May 2;79(9):3982-91.

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Angiotensin type 1 receptor blockage reduces l-dopa-induced dyskinesia in the 6-OHDA model of Parkinson’s disease. Involvement of vascular endothelial growth factor and interleukin-1β.

Muñoz A, Garrido-Gil P, Dominguez-Meijide A, Labandeira- Garcia JL.

Exp Neurol.

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4,617 1 No

Activation of the double-stranded RNA- dependent protein kinase PKR by small ubiquitin-like modifier (SUMO).

de la Cruz-Herrera CF, Campagna M, García MA, Marcos-Villar L, Lang V, Baz-Martínez M, Gutiérrez S, Vidal A, Rodríguez MS, Esteban M, Rivas C.

J Biol Chem.

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A genome-wide association study on copy- number variation identifies a 11q11 loss as a

Fernandez-Rozadilla C, Cazier JB, Tomlinson I, Brea-Fernández A, Lamas MJ, Baiget M, López-Fernández LA, Clofent J, Bujanda

Hum Genet.

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candidate susceptibility variant for colorectal cancer.

L, Gonzalez D, de Castro L; EPICOLON Consortium, Hemminki K, Bessa X, Andreu M, Jover R, Xicola R, Llor X, Moreno V, Castells A, Castellví-Bel S, Carracedo A, Ruiz-Ponte C.

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Alcohol consumption and survival after a breast cancer diagnosis: a literature-based meta-analysis and collaborative analysis of data for 29,239 cases.

Ali AM, Schmidt MK, Bolla MK, Wang Q, Gago-Dominguez M, Castelao JE, Carracedo A, Garzón VM, Bojesen SE, Nordestgaard BG, Flyger H, Chang-Claude J, Vrieling A, Rudolph A, Seibold P, Nevanlinna H, Muranen TA, Aaltonen K, Blomqvist C, Matsuo K, Ito H, Iwata H, Horio A, John EM, Sherman M, Lissowska J, Figueroa J, Garcia-Closas M, Anton-Culver H, Shah M, Hopper JL, Trichopoulou A, Bueno-de-Mesquita B, Krogh V, Weiderpass E, Andersson A, Clavel-Chapelon F, Dossus L, Fagherazzi G, Peeters PH, Olsen A, Wishart GC, Easton DF, Borgquist S, Overvad K, Barricarte A, González CA, Sánchez MJ, Amiano P, Riboli E, Key T, Pharoah PD.

Cancer Epidemiol Biomarker s Prev.

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Interleukin-6 deletion in mice driven by aP2- Cre-ERT2 prevents against high-fat diet- induced gain weight and adiposity in female mice.

Navia B, Ferrer B, Giralt M, Comes G, Carrasco J, Molinero A, Quintana A, Leclerc J, Viollet B, Señarís RM, Hidalgo J.

Acta Physiol (Oxf).

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Polyglutamic acid-PEG nanocapsules as long circulating carriers for the delivery of docetaxel.

Lollo G, Rivera-Rodriguez GR, Bejaud J, Montier T, Passirani C, Benoit JP, García-Fuentes M, Alonso MJ, Torres D.

Eur J Pharm Biopharm.

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Cellular energy sensors: AMPK and beyond. López M, Diéguez C. Mol Cell

Endocrinol .

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Regulation of GPR55 in rat white adipose tissue and serum LPI by nutritional status, gestation, gender and pituitary factors.

Imbernon M, Whyte L, Diaz-Arteaga A, Russell WR, Moreno NR, Vazquez MJ, Gonzalez CR, Díaz-Ruiz A, Lopez M, Malagón MM, Ross RA, Dieguez C, Nogueiras R.

Mol Cell Endocrinol .

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Cross-talk between SIRT1 and endocrine factors: effects on energy homeostasis.

Quiñones M, Al-Massadi O, Fernø J, Nogueiras R. Mol Cell Endocrinol .

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Bonache S, Balmaña J, Carracedo A, Diez O, Vega A. Cancer Res Treat.

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Brain renin-angiotensin system and dopaminergic cell vulnerability.

Labandeira-García JL, Garrido-Gil P, Rodriguez-Pallares J, Valenzuela R, Borrajo A, Rodríguez-Perez AI.

Front Neuroanat .

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Identification of a novel PNPLA1 mutation in a Spanish family with autosomal recessive congenital ichthyosis.

Fachal L, Rodríguez-Pazos L, Ginarte M, Carracedo A, Toribio J, Vega A.

Br J Dermatol.

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Shamsudin Khan Y, Gutiérrez-de-Terán H, Boukharta L, Åqvist J.

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J Chem Inf Model.

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Synthesis of nonadeuterated 1α,25- dihydroxyvitamin D2.

Sigüeiro R, Álvarez A, Otero R, López-Pérez B, Carballa D, Regueira T, González-Berdullas P, Seoane S, Pérez-Fernández R, Mouriño A, Maestro MA.

J Steroid Biochem Mol Biol.

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Replication of previous genome-wide

association studies of psychiatric diseases in a large schizophrenia case-control sample from Spain.

Ivorra JL, Rivero O, Costas J, Iniesta R, Arrojo M, Ramos-Ríos R, Carracedo A, Palomo T, Rodriguez-Jimenez R, Cervilla J, Gutiérrez B, Molina E, Arango C, Alvarez M, Pascual JC, Pérez V, Saiz PA, García-Portilla MP, Bobes J, González-Pinto A, Zorrilla I, Haro JM, Bernardo M, Baca-García E, González JC, Hoenicka J, Moltó MD, Sanjuán J.

Schizophr Res.

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Gutiérrez-de-Terán H. The roles of computational chemistry in the ligand design of G protein-coupled receptors: how far have we come and what should we expect?

Future Med Chem.

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Orosomucoid secretion levels by epicardial adipose tissue as possible indicator of

endothelial dysfunction in diabetes mellitus or inflammation in coronary artery disease.

Fandiño-Vaquero R, Fernández-Trasancos A, Alvarez E, Ahmad S, Batista-Oliveira AL, Adrio B, Fernández AL, González-Juanatey JR, Eiras S.

Atheroscle rosis.

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Impaired adipogenesis and insulin resistance in epicardial fat-mesenchymal cells from patients with cardiovascular disease.

Fernández-Trasancos A, Fandiño-Vaquero R, Agra RM, Fernández AL, Viñuela JE, González-Juanatey JR, Eiras S.

J Cell Physiol.

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RNA-sequencing analysis reveals new alterations in cardiomyocyte cytoskeletal

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Lab Invest. 2014

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genes in patients with heart failure. Juanatey JR, Bertomeu V, Montero JA, Portolés M.

High incidence of large deletions in the PMS2 gene in Spanish Lynch syndrome families.

Brea-Fernández AJ, Cameselle-Teijeiro JM, Alenda C, Fernández- Rozadilla C, Cubiella J, Clofent J, Reñé JM, Anido U, Milá M, Balaguer F, Castells A, Castellvi-Bel S, Jover R, Carracedo A, Ruiz- Ponte C.

Clin Genet.

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Hypothalamic mTOR: the rookie energy sensor. Martínez de Morentin PB, Martinez-Sanchez N, Roa J, Ferno J, Nogueiras R, Tena-Sempere M, Dieguez C, Lopez M.

Curr Mol Med.

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A colorectal cancer susceptibility new variant at 4q26 in the Spanish population identified by genome-wide association analysis.

Real LM, Ruiz A, Gayán J, González-Pérez A, Sáez ME, Ramírez- Lorca R, Morón FJ, Velasco J, Marginet-Flinch R, Musulén E, Carrasco JM, Moreno-Rey C, Vázquez E, Chaves-Conde M, Moreno-Nogueira JA, Hidalgo-Pascual M, Ferrero-Herrero E, Castellví-Bel S, Castells A, Fernandez-Rozadilla C, Ruiz-Ponte C, Carracedo A, González B, Alonso S, Perucho M.

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Association between CASP8 -652 6N del polymorphism (rs3834129) and colorectal cancer risk: results from a multi-centric study.

Pardini B, Verderio P, Pizzamiglio S, Nici C, Maiorana MV, Naccarati A, Vodickova L, Vymetalkova V, Veneroni S, Daidone MG, Ravagnani F, Bianchi T, Bujanda L, Carracedo A, Castells A, Ruiz-Ponte C, Morreau H, Howarth K, Jones A, Castellví-Bel S, Li L, Tomlinson I, Van Wezel T, Vodicka P, Radice P, Peterlongo P;

EPICOLON Consortium.

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Endoplasmic reticulum stress induces different molecular structural alterations in human dilated and ischemic cardiomyopathy.

Ortega A, Roselló-Lletí E, Tarazón E, Molina-Navarro MM, Martínez-Dolz L, González-Juanatey JR, Lago F, Montoro- Mateos JD, Salvador A, Rivera M, Portolés M.

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Experimental evolution of an oncolytic vesicular stomatitis virus with increased selectivity for p53-deficient cells.

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Functional networks of nucleocytoplasmic transport-related genes differentiate ischemic and dilated cardiomyopathies. A new

therapeutic opportunity.

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Heart mitochondrial proteome study elucidates changes in cardiac energy

Roselló-Lletí E, Tarazón E, Barderas MG, Ortega A, Otero M, Molina-Navarro MM, Lago F, González-Juanatey JR, Salvador A,

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metabolism and antioxidant PRDX3 in human dilated cardiomyopathy.

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Large genomic rearrangements of BRCA1 and BRCA2 among patients referred for genetic analysis in Galicia (NW Spain): delimitation and mechanism of three novel BRCA1

rearrangements.

Fachal L, Blanco A, Santamariña M, Carracedo A, Vega A. PLoS One. 2014 Mar 31;9(3):e93306.

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Multiple sporadic colorectal cancers display a unique methylation phenotype.

Gonzalo V, Lozano JJ, Alonso-Espinaco V, Moreira L, Muñoz J, Pellisé M, Castellví-Bel S, Bessa X, Andreu M, Xicola RM, Llor X, Ruiz-Ponte C, Carracedo A, Jover R, Castells A, Balaguer F;

Gastrointestinal Oncology Group of the Spanish Gastroenterological Association.

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RNA sequencing analysis and atrial natriuretic peptide production in patients with dilated and ischemic cardiomyopathy.

Tarazón E, Roselló-Lletí E, Rivera M, Ortega A, Molina-Navarro MM, Triviño JC, Lago F, González-Juanatey JR, Orosa P, Montero JA, Salvador A, Portolés M.

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Tandem RNA chimeras contribute to

transcriptome diversity in human population and are associated with intronic genetic variants.

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The Application of the Open Pharmacological Concepts Triple Store (Open PHACTS) to Support Drug Discovery Research.

Ratnam J, Zdrazil B, Digles D, Cuadrado-Rodriguez E, Neefs JM, Tipney H, Siebes R, Waagmeester A, Bradley G, Chau CH, Richter L, Brea J, Evelo CT, Jacoby E, Senger S, Loza MI, Ecker GF, Chichester C.

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The MLH1 c.1852_1853delinsGC (p.K618A) variant in colorectal cancer: genetic association study in 18,723 individuals.

Abulí A, Bujanda L, Muñoz J, Buch S, Schafmayer C, Valeria Maiorana M, Veneroni S, van Wezel T, Liu T, Westers H, Esteban-Jurado C, Ocaña T, Piqué JM, Andreu M, Jover R, Carracedo A, Xicola RM, Llor X, Castells A; EPICOLON Consortium, Dunlop M, Hofstra R, Lindblom A, Wijnen J, Peterlongo P, Hampe J, Ruiz-Ponte C, Castellví-Bel S.

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Keränen H, Gutiérrez-de-Terán H, Åqvist J. Structural and energetic effects of A2A adenosine receptor mutations on agonist and antagonist binding.

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Review of novel aspects of the regulation of ghrelin secretion.

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Biodistribution and lymph node retention of polysaccharide-based immunostimulating nanocapsules.

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Nanocarriers & drug delivery:

rational design and applications.

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Novel insights on the structural determinants of clozapine and olanzapine multi-target binding profiles.

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Synthesis and biological evaluation of a series of aminoalkyl-tetralones and tetralols as dual dopamine/serotonin ligands.

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Usefulness of the QRS-T angle to improve long- term risk stratification of patients with acute myocardial infarction and depressed left ventricular ejection fraction.

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Brain-derived neurotrophic factor is expressed in rat and human placenta and its serum levels are similarly regulated throughout pregnancy in both species.

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Clin Endocrinol (Oxf).

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Virulence and polar tube protein genetic diversity of Nosema ceranae (Microsporidia) field isolates from Northern and Southern Europe in honeybees (Apis mellifera

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iberiensis).

Analysis of PTEN ubiquitylation and SUMOylation using molecular traps.

Lang V, Aillet F, Da Silva-Ferrada E, Xolalpa W, Zabaleta L, Rivas C, Rodriguez MS.

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A collaborative European exercise on mRNA- based body fluid/skin typing and

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van den Berge M, Carracedo A, Gomes I, Graham EA, Haas C, Hjort B, Hoff-Olsen P, Maroñas O, Mevåg B, Morling N, Niederstätter H, Parson W, Schneider PM, Court DS, Vidaki A, Sijen T.

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Allele frequencies of the five new European Standard Set (ESS) STRs and 15 established STRs in a Turkish population.

Bulbul O, Fernandez-Formoso L, Phillips C, Altuncul H, Filoglu G, Lareu MV, Carracedo A.

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Building a forensic ancestry panel from the ground up: The EUROFORGEN Global AIM-SNP set.

Phillips C, Parson W, Lundsberg B, Santos C, Freire-Aradas A, Torres M, Eduardoff M, Børsting C, Johansen P, Fondevila M, Morling N, Schneider P; EUROFORGEN-NoE Consortium, Carracedo A, Lareu MV.

Forensic Sci Int Genet.

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Development of a forensic skin colour predictive test.

Maroñas O, Phillips C, Söchtig J, Gomez-Tato A, Cruz R, Alvarez- Dios J, de Cal MC, Ruiz Y, Fondevila M, Carracedo Á, Lareu MV.

Forensic Sci Int Genet.

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Exploring iris colour prediction and ancestry inference in admixed populations of South America.

Freire-Aradas A, Ruiz Y, Phillips C, Maroñas O, Söchtig J, Tato AG, Dios JÁ, de Cal MC, Silbiger VN, Luchessi AD, Luchessi AD, Chiurillo MA, Carracedo Á, Lareu MV.

Forensic Sci Int Genet.

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Global population variability in Qiagen Investigator HDplex STRs.

Phillips C, Fernandez-Formoso L, Gelabert-Besada M, García- Magariños M, Amigo J, Carracedo A, Lareu MV.

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SNP variation with latitude: Analysis of the SNPforID 52-plex markers in north, mid-region and south Chilean populations.

Moreno F, Freire-Aradas A, Phillips C, Fondevila M, Carracedo Á, Lareu MV.

Forensic Sci Int Genet.

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Update of the guidelines for the publication of genetic population data.

Carracedo A, Butler JM, Gusmão L, Linacre A, Parson W, Roewer L, Schneider PM.

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