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Angiotensin II Regulated Autophagy Is Required for Vascular Smooth Muscle Cell Hypertrophy

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Academic year: 2020

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FIGURE 1 | Ang II induces autophagy in A7r5 and RASMCs. (A) A7r5 cells were stimulated with Ang II 100 nM for 0, 0.5, 1, 3, 6, 12, 24, and 48 h (left panel) and with 1, 10, and 100 nM for 24 h, in presence and absence of CQ 30 µM, added for the last 4 h of
FIGURE 2 | Ang induces phagophore initiation and elongation in A7r5 and RASMCs. (A) A7r5 and RASMCs cells were stimulated with Ang II 100 nM for 24 h.
FIGURE 3 | Ang II induces autophagy through an AT1R-dependent mechanism. (A) A7r5 cells were pre-treated with Losartan 1 µM 1 h before stimulation with Ang II 100 nM for 24 h
FIGURE 4 | Ang II induces autophagy through a ROCK-dependent mechanism. (A,B) A7r5 cells were stimulated with 100 nM of Ang II for 24 h
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