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Platelets contribute to hemostasis, thrombosis, and allergic airway inflammation via Munc13 4 dependent secretion

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Figure 2.1. Primary and secondary hemostasis. Primary hemostasis refers to the physiological  process  by  which  platelets  adhere  to  the  site  of  injury  and form a  plug
Figure 2.2. Platelet secretory granules. Alpha granules are the largest and most abundant, and  contain close to 300 different proteins
Figure 2.3. Constitutive and regulated exocytosis. Cells use constitutive exocytosis to ensure  homeostasis  of  the  plasma  membrane,  regulate  cell  polarity,  and  release  components  of  the  extracellular matrix
Figure 2.4. Sequential steps of exocytosis. First, secretory vesicles are transported from the  cytosol toward the plasma membrane (trafficking), where they are recognized and “tethered” by  specific  factors  (tethering)
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