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Neuroendocrine metabolic dysfunction and sleep disturbances in neurodegenerative disorders: focus on Alzheimer's disease and melatonin

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Academic year: 2020

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Figure

Fig. 1.  Possible factors implicated in eating behavior and food in- in-take in AD. Eating behavior is regulated by hedonic, homeostatic  and peripheral signals
Fig. 2.  Disrupted brain insulin-signaling in AD. Amyloid-β (Aβ)  accumulation enhances tumor necrosis factor-alpha (TNFα) levels  and activates c-Jun N-terminal kinase (JNK)
Fig. 3.  Sleep disruption, particularly of  slow-wave sleep, and altered feeding  be-havior, are frequent features in AD

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