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p75 Neurotrophin Receptor mediated Apoptosis in Sympathetic Neurons Involves a Biphasic Activation of JNK and Up regulation of Tumor Necrosis Factor alpha converting Enzyme/ADAM17

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Academic year: 2020

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FIGURE 4. p75NTR activates JNK in a biphasic manner, initially indepen- indepen-dent of cleavage, then in a manner depenindepen-dent on receptor proteolysis.
FIGURE 6. BDNF-induced p75NTR cleavage in sympathetic neurons requires protein synthesis and correlates with up-regulation of TACE.
FIGURE 8. Inhibition or down-regulation of TACE blocks ligand-depen- ligand-depen-dent p75NTR cleavage and apoptosis in sympathetic neurons

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