Caracterització de la infecció pel virus de l'hepatitis C en el marc del trasplantament hepàtic: estudi de l'expressió dels receptors d'entrada i dels antigens virals
Texto completo
(2)
(3) . .
(4) .
(5)
(6) .
(7)
(8)
(9) $ .
(10) " *$ ( !*( $( ( & ! !
(11) ) ) $ #" )
(12) (-+,. .
(13) . .
(14) #$&"!' &($&'' $, +&* ! )!& !!&(1 $!" ' " 1""! ( #! 1!" ( " '! #(#! $ !"" / $' %)! $&&. " !#" $ 1" "*1!"(" $ !"" .
(15)
(16) #"!" ""
(17) . 4
(18)
(19)
(20) 2 . 4 4
(21)
(22)
(23) 1 !" # ! ! " # " "!"" "&!"!" +%""!! #!"! !! ! ! !$" #1$#+ !"0 &3$,+&*!)!&!!&(&3$' %)! $&& " !! .4235 .
(24) . .
(25)
(26)
(27) .
(28) . .
(29) .
(30)
(31)
(32)
(33) .
(34) . .
(35) #.%$. #7 - ,#* #7 $ "'# #$2 .!".9! 4 " #(5 ! 9 "*!4 +*8!$ "&
(36) '$2 " ! * 4 #7 # 2 &2 & !+ ) ! 4 &!5"!54 !2 &!4 ! ! 4 " !( !!4 #% %# 2'!!4 !$2 !$6 $3 %#2 &2 #2
(37) 2#6 # $##12 ! ! $4 - !22 ! 9 #4 !% " $ 4 ! !4 #7#$! 7 (824! 59 :*:4 " ( " 9 4 ! -4 $2 #0 % 3 !2$2 " '!2 & ) ! 4 &2 " !4 " 2 5!5! " 4 4 !2 #%2 " & 2 !+5." 9# ! 4 ! 2 - ! ! ! ! ! !4( ! 4 ! 9 "*!4 !! & !$4 ! !%% ! !!4% ! 4
(38) ! "2 4 " 2 ! !*(#5"4 # $ #+* ## 7 #)2 # $ $2$2 #$% !# 984 ( !2 ! 4 !2 !2!( !! 4& !% 2 ". ! !!" !2 !!9& ! ! ! ( !9! " %4 & " 2 (4 " (4 !.
(39) ## $-#; " #)"< #" % " @ !% % &"<#)$""9<A;$#%# "##,##$?$# !%;",%#8 0"= $%8 *# *.8 " "< "$%$$ %# )# B$"" 2 "$"; "#$"< "$"&#?%##%# "$#;% B##)$ #"8!3#$"<#####%$$"%"& "$ ,# $#$ !% #& !% $$ #"$ "&,#; "*# " $& 2 $-8 "#&"* "#$$; " "< #"%$" +; ""<#$$; "1 "#"$$8"*# " #$""%"$$; ,"."$$#!%# "##!%8$$ "$"$#-"#8 ($ % #) > ?"$ " "$ "$ #&% $ B!%#$ $#: ()' '2 %$)( %$"7( @#% # #8%##$#=A8'()$ ""/$8*($ '28 + ""% @#=A8
(40) *' %8 $' *%8 '$
(41) /.'% @" # %#A8 %$ ')2$.8
(42) *' "')8 5$ '2$8 ') +28 ( /$.8 '
(43) %$%4%8 + 1'.8
(44) %')% %-8 *$#
(45) 6&.8"+%' ')2$.8*()2$ %'2*.8 %(&%()8##1'.8 8 ')2$%$; '$$$$"$="#$)8 ";"')$("'8"& $ "$%$)$'"#; &'"#$$( "##'"$% "$$$$)%$$ ")%"; '% $&# $#$$+8'$'$ ' # $$#$$#"'$; '%$$
(46) *'$) @#
(47) %"%8'$0%(" '%#A '$8"$$$")$#$ &&""$#%";)%8 %*$@ A8 '%$#)$)%"$&")$ $';)% %""#=##'$)%8)8)%";$)%: '')8"((8$"8 '!%8$"8 '%$$)'()%)',<$ )% " )%" ##8 )%" )%" "# ; ) $ " '# '"% "$$ ( " ) ; $' $ "# '# " " ')%; ##)%#%= "."$,#&"## "##!%%$%"$#%#&$#8!% "$$ #&  2 8 B!%#$ "8 "!%$ &; ##B : ')8$$%))8'8
(48) 8$8'()$$$%''""; "*# " &"< $ "%" $# "-$# " &"< $ #$$8 "$ "8 %"$ # &# "## (#$#; " #$" #$$; # $#&#%$##!%#!% "&%"; $ B
(49) "; " $$# !%# !% #$% # !% # !% #$% "1!%$ "(%;# $%8'%"8 "#$"#$$ "$&%$#% "2#$$9$%$08 "$&&%$$&$; "!%+(#" ""#$%)9$%8##+&')'$8!%# $&# "%# ,# & %" " # " #2 !% & +)" .
(50)
(51)
(52)
(53)
(54)
(55) ' 4,
(56) 4 $
(57) 6
(58)
(59) 1"6 7!
(60)
(61) 4 &) 1 4
(62) 11
(63) 11
(64)
(65) 4$
(66)
(67)
(68) #
(69) 4 + 1$"
(70) 5
(71) 7
(72) &
(73) 7
(74) 1 , 7
(75)
(76) %
(77) 74
(78)
(79) 3 1
(80)
(81) 4 &
(82)
(83)
(84)
(85) 4 &
(86)
(87)
(88)
(89) $
(90)
(91)
(92)
(93) 4
(94)
(95) 7
(96) 4 $
(97) "6 '
(98)
(99) 7"4 1
(100)
(101)
(102) 4 &
(103)
(104)
(105) "!
(106)
(107)
(108) (1
(109) $1"
(110) 1+
(111) 5 1
(112)
(113) 5 5
(114) 4 &
(115)
(116) 7
(117)
(118)
(119)
(120)
(121) !
(122) !
(123) 4 $ !
(124) 5
(125)
(126)
(127)
(128)
(129)
(130) 4
(131)
(132)
(133)
(134)
(135) %
(136) 1
(137) !(
(138)
(139) !
(140)
(141) 4
(142) 1
(143)
(144)
(145)
(146)
(147) 4 && 5
(148)
(149)
(150)
(151)
(152)
(153)
(154)
(155)
(156)
(157)
(158)
(159)
(160) 4$
(161)
(162) %
(163) 4!7
(164) !
(165) 5
(166) &
(167)
(168)
(169)
(170) 4
(171)
(172)
(173)
(174) 3 2
(175) 4"+
(176)
(177)
(178)
(179)
(180)
(181) 4
(182)
(183)
(184)
(185)
(186)
(187) 7 "
(188) 7
(189)
(190)
(191) 4
(192)
(193) 1
(194)
(195) !&'
(196) 4
(197)
(198)
(199)
(200) 1
(201)
(202)
(203) 7
(204) %
(205) %
(206) 444 + !
(207)
(208)
(209)
(210) ,4
(211)
(212) ( 5 ,
(213)
(214)
(215)
(216)
(217) 1 1
(218) 4
(219)
(220)
(221)
(222)
(223)
(224)
(225) ' '4$56
(226)
(227)
(228) (
(229)
(230) 1
(231) #4 1 1 7
(232)
(233)
(234)
(235) 1
(236)
(237) 51
(238) '
(239) !+ 4 1
(240) 7
(241) 4
(242)
(243) (
(244) #37
(245) 1
(246)
(247)
(248) &!4 7$
(249)
(250) 7$
(251) 1
(252)
(253)
(254)
(255) 57
(256) !4$
(257) 5
(258)
(259)
(260) 1
(261)
(262) 1
(263)
(264) 7
(265) (47
(266) 1
(267) ,4 $
(268) $
(269)
(270) 4 &
(271)
(272) '
(273)
(274) ,
(275) & %
(276) 4
(277) '
(278)
(279)
(280) +1+
(281) 4.
(282)
(283)
(284) 4 4$
(285) 1.
(286) $$#$# ""@!%#$-%"->$$###$$#?9 $$# &#$"#8 6 6 ! +7 !6 " $7 "" #7 6 &$6 % !7 "6 '6 ( 7 % %$#;&#$"#$$"#%$ ##$$##"#$# &&9 6 " $& &$ "#&")9
(287) $ # #$"$# %"$$&"%$$")"9
(288) "!%+$" "$#"# +"#@#(&#!%#$)!%# %%"0""" $!%# %%##"9
(289) "!%+,# ##" ")$$!%#&## $" # #$" # "%"## " "%" !% 9 $%6 "6 % ###9 6!%#%"6"$# +$ $"%.$!%+#$%#+'$##&%##"$$9
(290) "6 " $& "# #16 $6 "#$$ #"$$9
(291) $%#% "$#$#,#"# "!%+# "1#### """"9
(292) "!%+@##%$"$ "-#6# "%#!%#9
(293) "#$": "*":!%##$$9
(294) "!%++'":$@ "+#$" "!%&"$$,#@#$$9 # #"#6 " !6 " $": $$ , #$": % ,#9 " *6 " ": "$ A*" $# # )""#A9 #%,@$#$""#$"$%$( "$$""%9##6 !6 #"## "$"#9 # "9+'":$$#$$#&#%# $$#!%#$#(#9")# "$":$$=%#1":#"%$"1 "#0 9 #":@ $% #&%$ #$9 ")# " $$# # $"$&# " #%" $"%" )' #( A ")#$A9
(295) "!%# "
(296)
(297) #"#$$$6)'+" ,# $"%#$9
(298) " $& "# #16 $$ $% "9 #$ $"&">%# %$$#6 "&";?9 "+#$$%$%9
(299) "!%+ " $# (# "'
(300) & # 9 $& #$$,###%$""!%@%@!%#$$ >CB?9 " 6 & @)9 ")# " #$" % #$$
(301) !%$##$9
(302) " $": "#$":9
(303) " "$" !%$#!%$#9
(304) "$$#$## #$#6!%#%$ ,#"*#$"+'"%$#9%!%!%$,%6$,%$"#"6 <6$%6@$$$";")# "'#$"6 %"$9")# "$$9 @!6 !% $$ !% " $ #$ #%" !% ")# @=%#1 $$##$"#	 $%66$!%#$ ")"$$!%@""$":$%" #"9#$%!%@".$,## @!%#$$#6 "!%+,#")# $% !% #$ &% !%-9 ")# " #" & =%#1 " #$"": !% # " % $"$% ##!% ##9
(305) !%##$$ !%$#9
(306) ".
(307) 0 - " / #
(308) / / -
(309)
(310) - -4 2 3/ -
(311) / # )
(312) / - - ! /
(313) % / 0 / #
(314) # -
(315)
(316) -
(317) $4 / -
(318) -
(319) / -
(320) - ! /
(321)
(322) ( / -
(323) 4/ / # (
(324) 4 / #
(325) # ' $ ( 0 / '- - -
(326) 0 . - 4
(327)
(328) / # (
(329) /
(330) 1 1 - ' 4)
(331) % / ,
(332) + +* )! *
(333) ! * " $
(334) &* % ,/ * * .
(335) . .
(336) ! . ( $ ## $) &% *& &
(337) ' " $ & &' ' . & ! !# 7,! ! ! !7 ! $" + 4 !"+#( " #%#! #!" #! ( $ !#! 5! !# + !" "" !!!7-6 ! !) 22 #!#% ! ! !# 5!) !" !!"6 " !!! <73! ! ! 5 !6 ! !"!15! '( ;6 '"%!$"%!$" #!5!#" $ 7#" 6 " "!$## #! $ +- " !,98 " !,=9 " " #! "9 !#" :! &# ( 546 !# + #!$! " $+0+! + #! ,! ! !" 7$ , '4" (!" 6 ((!
(338) +(#!"!".5'! 96 !) 9:7 ! !&# #! ! #! 5! ! $! '6 )(+ $"!# ""( 5 7" , !% 6 !#( +! #!/5!:7 !" 6 !!
(339) ! 7' ! !$"#!#5 !,7! &
(340) 6 !+'* ! 5$ 6 !#.
(341) &. . . . . "'. . . . ! . !"" ! ! %# $. $
(342) . !! #& #$%!# %5 "+$ # !"6 " !!. " $%*! !# %5 "+8"!""6 "-"!#! ! !#" !#$&%!# % *5 "'8 !#"6 *4# 8" #' " . " ." ## ## " ##:> "! " "# %## $ %#*$%5" 8" !6 %## $$%'%* %# # 5 . !!"" 8" .6 &% $ &$5)#!8#.!.6 ""!#"!9. '#,*! +! %#&# $ &+.+# %#5 " "!8% !!."'"6. ( !)%*"&5!/)%%""6. !# !%5"*6. ($%* ! !# %5""+%!""6. ( $%* ! !# % !% # 5 " "+! % !""6 (%" 4# . &#$5# !6 39:: &# &#&$5$ #!#)# 6 # $ #**# #$# # % 5 "+ ! " ! )" ) !6. #-"! #!""!
(343) 5"6 " 3
(344) 939
(345) "+!!!" #"# !. #-"!" !" # "&.#!#" !##5 "# "6
(346) "+=; )4#!# !! ) *#$% 5 . !6 $$*!- $!%* $% /+ $5!"!"<3#! !!"#!76 $!%* $% /+ $5!"!"<3#!6.
(347) !
(348) . . #&$'+ "#&'# 1-#&$'7#$#$<5#$8 %#'" "&7 "$-!%#
(349) 8 ("''') )%& %"&%$'#" 7"$"$"#" 0 "0 "#!%$$$&8
(350) &"
(351) %6%"%$ -$""' $# +!%&7 "#9
(352) $9
(353) 8
(354) $ #)$ &'%'#" %!"' "' # +!#%$&! 7 "## $%$ "$#"#$"08
(355) 0 "&":; '"#-"( "-75:%- "9)"$8 +%#&""&%$'#%7" $"$"#!%#8 $ '#"& &7&#,%#" 08
(356) # #$&"/##$% )% #!" !!("#"+ 7%+ "%8 "#% "$-; )"%%$'#% &&'+$07" $"#""##$ %# :8 '%&$"" "%
(357) %##!"& 7"# "!%$# $$"# #8 "# $$ )$ -"'%'"$%#'"#127 "$-%9$"0<= 8 ' ("'#"&7%##$"$#8 %"&%$'#"-
(358) ' !$ '#" 7 0 $*$ $"#" 08 # ."'% ("-0 $'#% #!"-#"'"" $'#% "(" -/ 7+% $"#" $"#9$"%!% 8 $$#$"# "6$" & -&&#' !!%" $%#'", &&#' $%#'" 7 "$- "##&#,%#4## "$-8 & -&&#' !!%" $%#'", &&#' $%#'" 7 "$- "##&#,%#4## "$-8 "%#9 $$# "%#9 $$# "%#9 $$#. . %$%6%". . #% "$,%#. . #$ "$,%#$"# $# "%#9 $$# "%#%+%!%" %+ #*"&'+ $#$%#'"7 "$-$'#$$8 #"( ("&07(0%%#:8.
(359) !" . . .
(360) . .
(361)
(362) . :;. . . 929$$# . :=. 92:&"#$$*$. :A. 92;#$-"$%". ;9. 92< *$#$.-#$. ;;. 92<29$.8$###$3. ;;. 92<2:$.!%$.8$". ;=. 92<2;$.!%$.8
(363) . ;=. . 92<2;29#$#!%$$%#. ;=. . 92<2;2:#$#!%$$$%#. ;>. 92<2<$ $. ;>. 92= $$#"# $$ )$. ;@. 92> $$#"$$. <9. 92>29$#$&"#"$#67. <:. . 92>2929 "# "$#
(364) ;3<6 7. <:. . 92>292: "# "#
(365) =6 7. <;. . . 92>292:29)#%-##4%-$#. <;. . . 92>292:2:)#%-##. <;. . 92>292; "#
(366) =. <<. . 92>292< "#". <<. . 92>292= "# ?. <=. . 92>292> "#
(367) <. <=. . 92>292? "#8 . <>. . 92>292@$###%$"$($#$"8. <>. 92>2:$#"$#$"8#$67. <?. . 92>2:29 "#56' 7. <?. . 92>2:2:$#$#"
(368) 39::6 39::7. <?. . 92>2:2; "#!%##$#$3<6 < 7. <?. 92>2:2< "#" 3$"#"#9 697 "$+"#$"# "$" $"*"#6 7. <@ .
(369) . ;5@5<5? !#$$#"%!#$9 %# . >B. ;5A!!!&# . ?:. ;5A5;#!%, !#. ?=. ;5A5<#!%, $9!. ?>. ;5A5=#!%, "A. ?>. ;5A5>#!%, <. ??. ;5A5?#!%, =6 >. ??. ;5A5@#!%, >. ?@. ;5A5A#!%, ?. ?@. ;5A5B#!%, ?. ?A. ;5B
(370) !$9$%& . ?B. ;5B5;
(371) !$
(372)
(373) . ?B. ;5B5<
(374) !$
(375) . ?C. . ;5B5<5;$$%$"$&!"#%+&$. @:. . ;5B5<5<$$%#"/. @;. ;5C' . @?. ;5C5; 9"%.%4+ & %%& ! . @?. ;5C5< 9 %# . @A. . ;5C5<5;!$ ! $7$8. @B. . ;5C5<5<"%!#$"!"#!%, $( $%%7 #8. @C. . ;5C5<5=' #"%!#$$)" 76;8. @C. . ;5C5<5>&$%## /B;7B;8. A:. . ;5C5<5?& 6;7 ;8. A;. . ;5C5<5@& 7 8. A<. . ;5C5<5A . 6;6 ;7 ; ;8. A<. . ;5C5<5B"%!#%!##( %"*# 78"%!#<9" # $%"&$7"<8. A= . ;5C5="/3$$%# %. A>. . ;5C5=5; $ #"/ . A?. . ;5C5=5< '$#/"#%+&$ 4$$% # % . . A@ .
(376)
(377) . AC. . . .
(378) . .
(379)
(380)
(381)
(382)
(383)
(384)
(385)
(386)
(387)
(388)
(389)
(390)
(391) . .
(392)
(393)
(394)
(395)
(396)
(397)
(398)
(399)
(400)
(401) . . . . .
(402) .
(403) .
(404)
(405)
(406) . .
(407) .
(408)
(409)
(410)
(411)
(412)
(413)
(414)
(415)
(416)
(417)
(418)
(419)
(420) .
(421) .
(422)
(423)
(424)
(425)
(426)
(427)
(428)
(429)
(430)
(431) .
(432)
(433) . . .
(434) .
(435)
(436) .
(437) !/% F. . %# &3 . .
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
(439) #%*3 &&%A
(440) B:$C$%"&&%!#(HI. . GJ.
(441) $ % # . . &# $. $ '$ $ # .$ AC>9>>> !#$ $ !# %$ !+%"&$# $9=%&%%$ $%"&&%&$ AC>9>>> &$$ $=!%%$ !2&$?C>9>>>$$%%$%$=-# ;< &# !
(442) %8 "& $&! $ & # !% ' $ 19. 2 ! %. & $%#&2 &'#$ !#1 $' !#', '# $#%%#!/$ $&2! #%+"&! $$( $ #%$ $$ %#$$$29 "&$% .$ +( ;I?>H< '#$ $!/$ $=# %##
(443) #%8$$%!% # !#',2'&;?E8CH<;<9$$=$%&# =%#=?8AH=?8GH;<8&$!/$ $&# !&$ &-8) /$ $ ( $.$>8BH%#"&&$#%$ %##$(#&@H: AH ;$&!#% CH &$ &%%$ =%+< ;< ; 3<9 $%&$ ! 1$ #%*%$ $!) (# %# BF>9>>> CD>9>>> # !#$ $ %: ! $%'$8 "& $&! $ & !#', %# =?H @8DH9 $=$!)8($%(#-$ #+"&$& #%2$ &%%$ &%1 $ .$ &#%*$ ;%# @8C @8DH # %&)#$!%'%< #$)$&#%*$;?8DH$%3#$<9. 39 !# ' 1 / + 42240./7+5;0,$/3+9;0,/6+8;0, /3+25;0, /4+37;0+ %/5+:;0,
(444) -5+3;/- +" 0.. . . @D.
(445) * @. . !. . ! ! . ! ! " <
(446) =5 5 ! ! ! . 5 ! ! #. ! 8 !. ) ) (5 ! ! - 7! !!> > B?9C? $5 . ! ) !+ ! ! " 6 > E? $5 ! . !! " >$ @HH? < ! ' % -
(447) !*>.?8AI ! =8 ( # . ) AD CD $5))""' ! ! # "))0 ! !>"!8
(448) "5 )'>/ ! " " 8 $5 "'>/! "! !( ! <
(449) = " ! HF5BI @HHF @C5DI A??E8 ;>"&"'.
(450) 5 ! & FB5GI @H5GI # <=8 & !""'.5!) ">!*! & ! <
(451) =8 ..! 5#* !!!# > %.5 ) ! . <
(452)
(453) =5 ' >/ >! & "!8. # .: 5 ! - ! !# ! ! >!. 8 - ! # ! ) >#. < !! (5 ! 5 5 !! !5 5 8=<
(454)
(455) =8 ! .#!5# # "(>!)" - #! 8 . AF.
(456) . . . - (
(457) +% ( ( ),( $
(458) - $ (
(459) +
(460) ,)- $ # ) $ # - $(
(461) ! /1+ ,) *
(462) + ,#
(463) ( ( $ + ,) ! $ +
(464) ,+ , -
(465) " $ + ,) . .0.
(466) !-% @. . %# &1 .
(467)
(468)
(469) $ % >'& $> %% F %!&$ '#&$ %*% >)$ +% #%$ .%$ <
(470) =: $ #%$ %!&$ #(%#&B?I;BDI$'$"3+& %-&>"&$%$ $%)'%#%$$&%!&$<888%=8$$"3+$$"&$'#( %# A?I;ADI: & '& %% $>$% "& $ !# &(8 !# (%8&$@?@A!#%-&$'#$!#: >'%(#!18 &%%%"&! #$'# %,%'%% ##% #>## #$<@ !# @?C;@?D &0%$=8 ! #% & # %# .%% +% $ >& %( ! 1 '#8 "& $ ( %# "&$$!+: # %%8 & %( '&8 #& & ! 1 $ $%#%% # %$ & '#1 & %- > ## >@;AI < =: $ %!&$%&!#'*$%#&1 #) %'#$9 %!@<@@=,$,$ 2$&# !8% %"&$%# ##& 1,$&$%E?I$$ $>!%%$:$&( %!A<A A= $!#,$ B <!# %% B=: !%8 # # >
(471) #%. %) %! C ,$ ,$ !#'% %# "& D E !# & #:$%+ %!8$#%#%%8$>%# %!%$!2 #)% <=: %! %, ! #% - "& %# '#&+ #$! $% %#%%: $ !%$ %%$ ! %! A '#&$ $1 $ "& % ,$ !# %%$>#; $!#,$%#)!%##1< =8$$ %%($ #$! $% '# $ $%& <= ' %% G?I: %#)#%8 $ %!&$@C$1$"&%!% ##$! $%%#%%8$$%$' #$ # #$D?I!#$!%$ %!@: . . AH.
(472) "#! . . " #! !# *"" #!! 7 !#$&'. $! ". # "#!$# !7$! # )" - !!$,. "!# 4 4 . "#!$# !# !7!"$ # "#!$# 7 !# #'4 ""# #!## ( 5%3 " $"#"""6. *#
(473) 2 #$"#!'. "#!$# '#
(474) 2 !#$!# $!. #
(475)
(476)
(477)
(478)
(479)
(480)
(481)
(482)
(483)
(484)
(485)
(486)
(487)
(488)
(489) !" !". . . 98.
(490) )=. . , .
(491)
(492) + ,(); ' !( 1 1 % 9A<5 B@E :4 ,9 :16 ! 3 :4 =@E5>@E;! , % 2:4 B@E5C@E 1 " $ , 1 ' ; 5
(493) (% " + 9:4 ! ,(! % 4 ; ! ! >C 9 >C: ; , % ! 9 : " ( 1 " ;,+
(494) ") ! , ; ,9F@< #:1 ' 9" ):1 & 9 ! %:1 , ! 9
(495) 7
(496) :1 + 1 ) + 1 ;)" ; 9F?<7 : 9 :4%! ! =<5@< # ' !5) # 8 , + + 4 ' ; ) 1+1( , , + ,1 " ; , 4 , ( ! 1 " 1 ; ( ! & 9:4 ?
(497) ) ; ! ! , 9:4 -' , ' 8 , 1 , 9 1 % 1 % ! ! % 1 ) 1 ) :1 # ( ; 4 " !!' % ( DAE1 D=E BDE ?1 @ =< # ! ; , ( @E . ?=.
(498)
(499) . .
(500) .
(501)
(502) -*0 +*
(503)
(504) '(%
(505)
(506)
(507)
(508) $
(509)
(510)
(511)
(512)
(513) /*0 /'(%
(514) +/0
(515)
(516)
(517)
(518)
(519) .
(520)
(521) &$
(522)
(523)
(524)
(525)
(526)
(527) )+0 .0%
(528)
(529)
(530)
(531)
(532)
(533)
(534)
(535)
(536)
(537)
(538)
(539)
(540) & )!
(541)
(542)
(543) ' (% .
(544)
Documento similar
First, we must remember that time travel (specially a trip to the past, or a two-way trip) would only be possible in the block universe. In the presentist alternative,
(A) Distribution of the total pangenome after core genome multilocus sequence typing (cgMLST) analysis in core (genes present it at least 95% of the isolates; 7.6%), accessory
This technique efficiently allowed the release of Nrf2 for its nuclear translocation: higher levels of nuclear Nrf2 were detected under basal conditions and after 4 and 8 hours of
(a) NPs@PEG in the liver, (b) NPs@Glc in the liver and (c) NPs@Glc in the spleen at different post-administration times (72 h and four months). If in the spleen the core of
The objective of the present study was to analyse the presence of PCV-3 infection (by qPCR and ISH) in for- malin-fixed paraffin-embedded (FFPE) samples from retrospective
In this study, internal tissues of chicken liver samples were analysed for the presence of phages using a meta- genomics approach and the liver virome was compared with that of
In our study, admitted COVID-19 patients with CLD and abnormal admission LFTs had higher median levels of D-dimer, which could be associated with major systemic inflammation and
The Dwellers in the Garden of Allah 109... The Dwellers in the Garden of Allah