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Potential drug delivery system: study of the association of a model nitroimidazole drug with aggregates of amphiphilic polymers on aqueous solution

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Academic year: 2020

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FIGURE 2  - Reaction of the anhydride group with an aliphatic amine or alcohol (CH 3 -(CH 2 ) n -R) leading to the formation of  hemiamide or ester groups in poly(maleic anhydride-co-vinyl-2-pyrrolidone).
TABLE 1  - Conversion degrees for reaction of anhydride group  with aliphatic amines or alcohols to give PMAVP-N-n or  PMAVP-O-n HMP Conversion degree (%) PMAVP-N-2 84 PMAVP-N-4 81 PMAVP-N-6 88 PMAVP-N-8 87 PMAVP-N-10 91 PMAVP-O-2 75 PMAVP-O-4 37 PMAVP-O-6
FIGURE 3  - Plot of ratio I 3 /I 1  of pyrene as a function of  pH of aqueous solutions of PMAVP-N-n copolymers

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